Blue Light, Green Light, White Light, More Light: Treatment of Neonatal Jaundice

Ennever, John F.

doi:10.1016/s0095-5108(18)30579-7

Cited by 120 publications

(82 citation statements)

References 50 publications

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“…15 The increased efficacy of green light may thus be partly explained by its longer wavelength and therefore deeper penetration into the dermal blood vessels. 16 In summary, this study demonstrates a need for a shorter duration of phototherapy in infants who were nursed supine as opposed to those who were turned. The proposed model of bilirubin kinetics during phototherapy may explain the findings.…”

Section: Discussionmentioning

confidence: 68%

Effect of Position Changing on Bilirubin Levels During Phototherapy

2002

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Section: Discussionmentioning

confidence: 68%

Effect of Position Changing on Bilirubin Levels During Phototherapy

2002

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Section: Introductionmentioning

confidence: 99%

“…1 At these wavelengths, light penetrates the skin well and is absorbed strongly by bilirubin. 1,2 Thus, special blue fluorescent (BB) tubes that have their output primarily in the blue spectrum (430 to 490 nm) are recommended by the American Academy of Pediatrics (AAP) as the most effective light source for lowering the serum bilirubin. 3 Prototype light-emitting diode (LED) lights have been developed and tested in clinical and laboratory studies, [4][5][6] and a commercially available LED device is being used, currently, in nurseries in the United States.…”

Section: Introductionmentioning

confidence: 99%

Randomized controlled trial of light-emitting diode phototherapy

2007

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Objective: We wished to compare the efficacy of light-emitting diode (LED) phototherapy with special blue fluorescent (BB) tube phototherapy in the treatment of neonatal hyperbilirubinemia. Study design:We randomly assigned 66 infantsX35 weeks of gestation to receive phototherapy using an LED device or BB. In addition to phototherapy from above, all infants also received phototherapy from below using four BB tubes or a fiberoptic pad.Result: After 15±5 h of phototherapy, the rate of decline in the total serum bilirubin (TSB) was 0.35±0.25 mg/dl/h in the LED group vs 0.27±0.25 mg/dl/h in the BB group (P ¼ 0.20).Conclusion: LED phototherapy is as effective as BB phototherapy in lowering serum bilirubin levels in term and near-term newborns.

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“…Since bilirubin is a yellow pigment, during phototherapy, the blue and green light is best absorbed by the bilirubin molecule. 2 When broad-spectrum white light is used for treatment, only a fraction of the light is acting on the bilirubin. 3 Moreover, bilirubin does not absorb the different colors of light equally.…”

Section: Introductionmentioning

confidence: 99%

“…Blue light at about 450 nm is absorbed most readily, while green light is less well absorbed. 2 However, in order for the light to be effective, it must penetrate the newborn's skin.…”

Section: Introductionmentioning

confidence: 99%

A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy

et al. 2003

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OBJECTIVE:To determine the efficacy of blue versus blue-green phototherapy using new light sources with narrow luminous spectra. The devices made of highintensity gallium nitride light-emitting diodes (LEDs) were also compared to conventional halogen-quartz bulbs phototherapy. DESIGN:Prospective open randomized study. PARTICIPANTS:A total of 114 jaundiced, but otherwise healthy term infants who met the entry criteria for phototherapy set by the American Academy of Pediatrics' Practice Parameter. MAIN OUTCOME MEASURES:The duration of phototherapy and the rate of decrease in total serum bilirubin (TSB). RESULTS:The mean TSB concentrations at initiation and termination of treatment, as well as the duration of phototherapy and the rate of decrease in TSB, were not statistically different in newborns receiving blue LED, blue-green LED or conventional phototherapy. The average rate of decrease in TSB (slope), after adjustment by a linear regression analysis for confounding factors, was À3.61 mmol/hour (95% confidence limits À5.47, À1.75) in the 25 newborns receiving blue LED phototherapy compared with À2.57 mmol/hour (À4.32, À0.82) in the 22 newborns treated with bluegreen LED phototherapy and À3.42 mmol/hour (À5.02, À1.81) in the 57 newborns who received conventional phototherapy. CONCLUSIONS:When using low light irradiance, there was no statistically significant difference in the effectiveness of phototherapy using blue-green LEDs, blue LEDs or conventional halogen-quartz bulbs.

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Blue Light, Green Light, White Light, More Light: Treatment of Neonatal Jaundice

Cited by 120 publications

References 50 publications

Effect of Position Changing on Bilirubin Levels During Phototherapy

Effect of Position Changing on Bilirubin Levels During Phototherapy

Randomized controlled trial of light-emitting diode phototherapy

A Prospective Randomized Controlled Study of Phototherapy Using Blue and Blue-Green Light-Emitting Devices, and Conventional Halogen-Quartz Phototherapy

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