Blue nevus and “malignant blue nevus:” A concise review

Sugianto, Jessica; Ralston, Jonathan; Metcalf, John S.; McFaddin, Courtney L.; Smith, Michael T.

doi:10.1053/j.semdp.2016.04.006

Cited by 20 publications

(16 citation statements)

References 19 publications

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“…For the purposes of this review, all three types will be considered together. It should be noted that additional types of benign melanocytic nevi such as: blue nevi, 32 Spitz nevi 33 and deep penetrating nevi 34 exist, however, are relatively less common and will not be discussed in detail. Dysplastic nevi will be considered separately below.…”

Section: Melanocytic Nevimentioning

confidence: 99%

Melanocytic nevi and melanoma: unraveling a complex relationship

2017

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Approximately 33% of melanomas are derived directly from benign, melanocytic nevi. Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAFV600E-activating mutations, will never progress to melanoma. Herein, we synthesize basic scientific insights and data from mouse models with common observations from clinical practice to comprehensively review melanocytic nevus biology. In particular, we focus on the mechanisms by which growth arrest is established after BRAFV600E mutation. Means by which growth arrest can be overcome and how melanocytic nevi relate to melanoma are also considered. Finally, we present a new conceptual paradigm for understanding the growth arrest of melanocytic nevi in vivo termed stable clonal expansion. This review builds upon the canonical hypothesis of oncogene-induced senescence in growth arrest and tumor suppression in melanocytic nevi and melanoma.

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Section: Melanocytic Nevimentioning

confidence: 99%

Melanocytic nevi and melanoma: unraveling a complex relationship

2017

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“…Common blue nevus: A blue nevus is a melanocytic lesion that is derived from dermal melanocytes that do not migrate to the epidermis during embryogenesis. They are most commonly found on the scalp, sacral area, and distal extensor extremities, and they appear as a well-circumscribed, darkly pigmented papule, often with a blue hue (Sugianto et al, 2016). This blue hue is due to the Tyndall effect, which is the preferential absorption of longer wavelengths (red) and the scattering of shorter wavelengths (blue) by the dermal melanin (Sugianto et al, 2016).…”

Section: Discussion Of Incorrect Answersmentioning

confidence: 99%

“…They are most commonly found on the scalp, sacral area, and distal extensor extremities, and they appear as a well-circumscribed, darkly pigmented papule, often with a blue hue (Sugianto et al, 2016). This blue hue is due to the Tyndall effect, which is the preferential absorption of longer wavelengths (red) and the scattering of shorter wavelengths (blue) by the dermal melanin (Sugianto et al, 2016). Blue nevi come in several variants, including common blue nevus, cellular blue nevus, epithelioid blue nevus, and pigmented epithelioid melanocytoma.…”

Section: Discussion Of Incorrect Answersmentioning

confidence: 99%

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Cells to Surgery Quiz: June 2019

Matsumoto

Nijhawan

2019

Journal of Investigative Dermatology

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“…Malignant blue nevi are a rare type of malignant tumor of melanocytes that can arise in cellular blue nevi. These tumors have histological features of melanomas, including atypical mitoses and necrosis, along with features of typical cellular blue nevi (6). These tumors are most commonly found on the head, particular the scalp, and are over 1 cm in diameter.…”

Section: Introductionmentioning

confidence: 99%

Common blue nevus with satellitosis on the scalp

Shah¹

2017

cderm

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SummaryBlue nevi are benign tumors of dermal melanocytes. They are typically dark blue to grey-black papules or nodules with well-defined borders. Within the spectrum of blue nevi there are several subtypes. In this case, we present a 71-year-old African American female who presented with a blue-black macule on the scalp concerning for a melanoma. After a shave biopsy, there was dark black pigmentation at the base of the biopsy specimen with areas of satellite pigmentation, a presentation that caused concern for transient metastases of a melanoma. However, histopathological examination of the lesion showed a banal appearing blue nevus with skip areas, no evidence of atypical melanocytes or mitotic activity, thus a diagnosis of blue nevus with satellitosis was rendered. To our knowledge, this is the 6 th reported case of blue nevus with satellitosis mimicking malignant melanoma.KEY WORDS: blue nevi; melanoma; satellitosis; atypical nevus.

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Blue nevus and “malignant blue nevus:” A concise review

Cited by 20 publications

References 19 publications

Melanocytic nevi and melanoma: unraveling a complex relationship

Melanocytic nevi and melanoma: unraveling a complex relationship

Cells to Surgery Quiz: June 2019

Common blue nevus with satellitosis on the scalp

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