Blue rubber bleb nevus syndrome

Abstract

A 21-year-old man had blue rubber bleb nevus syndrome: 1) hemangiomas of the skin all over the body; 2) hemangiomas of the digestive system; 3) iron-deficiency anemia. A giant mass of hemangiomas in the tranverse colon was resected surgically.

Blue Rubber Bleb Nevus Syndrome: A Clinical Spectrum with Correlation Between Cutaneous and Gastrointestinal Manifestations

“…All patients with multiple skin hemangiomas were found to have multiple gastrointestinal hemangiomas at laparotomy and vice versa. Nakagawara et al 4 . previously reported a correlation between the number of hemangiomas involving the body surface and the number of cutaneous hemangiomas.…”

“…Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder characterized by distinctive cutaneous and gastrointestinal cavernous hemangiomas. Patients usually present with iron deficiency anemia from occult gastrointestinal bleeding or massive gastrointestinal bleeding in the emergent setting 1–9 . Optimal management for these patients is unclear as a result of its rarity and anecdotal reporting.…”

Theoretical basis of a beneficial role for vitamin D in viral hepatitis

“…The TLR-3 polymorphism may predispose Asian Indian populations to HCV infection [106] and protect Han Chinese populations from HBV recurrence after liver transplantation [107] . TLR-7 polymorphisms are protective against from development of inflammation and fibrosis in male patients with chronic HCV infection and are predictive of the response to IFN treatment [108][109][110] . TLR-2 and TLR-4 polymorphisms are not associated with liver cirrhosis in HCV infected Korean patients [111] .…”

Blue Rubber Bleb Nevus Syndrome

“…In Bean's original patient the small bowel was resected when the child was age 7 years. Maier and Schulthess (6) reported a patient in whom selective hemicolectomy and partial resection of the small intestine were performed at age 9 years; Nakagawara et al (12) had a male patient in whom partial colectomy was performed at the age of 21 years after several blood transfusions. Selective excisions of hemangiomas of stomach, small intestine, and colon were also performed.…”

“…This article presents a review of the 22 pediatric patients with BRBN syndrome. Table 1 lists all published cases of BRBN syndrome of pediatric origin since Bean's original description (1,(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). The male:female ratio is 14:8.…”