Blue Rubber Bleb Nevus Syndrome as a Cause of Lower Digestive Bleeding

Abstract

Introduction. Blue rubber bleb nevus syndrome is a rare disorder that is characterized by multiple recurrent vascular malformations that involve the skin and the gastrointestinal tract. The disease can present chronic anemia and severe episodes of gastrointestinal bleeding. Case Report. A 41-year-old man was admitted with recurrent episodes of lower gastrointestinal bleeding and anemia that had worsened over the last 3 months. The physical examination showed soft, diffuse, compressible, bluish nodules on all of the skin surfaces of the body. A biopsy from one of these skin lesions allowed a histological diagnosis of cavernous hemangioma. He submitted to a colonoscopy, which showed hemorrhoids and a plane vascular lesion mainly located on the right colon with recent signs of bleeding; this lesion was treated by local excision and sclerosis. The pathological study of the colon specimens also reflected the presence of cavernous hemangioma. The cutaneous hemangiomas and the presence of colonic venous malformations were compatible with blue rubber bleb nevus syndrome. The patient presented a favorable follow-up with clinical control of the anemia and without relapse of the gastrointestinal bleeding two years after the procedure. Conclusion. Although rarely diagnosed, blue rubber bleb nevus syndrome may be responsible for lower digestive bleeding.

Postoperative disseminated intravascular coagulation in a pregnant patient with Blue Rubber Bleb Nevus Syndrome presenting with acute intestinal obstruction: Case report and literature review

“…Blue Rubber Blebs Nevus Syndrome (BRBNS) is a rare disease. It’s estimated incidence is 1:14.000 births [11] . The first description of the disease occurred in 1860 by Gascoyen, but the term “Blue Rubber Bleb Nevus Syndrome” was coined by Bean in 1958.…”

Blue rubber bleb nevus syndrome

“…In addition, thrombocytopenia, or chronic lymphocytic leukemia may occur in literature. [ 17 ] CT examination especially contrast-enhanced CT was the most valuable noninvasive screening procedure in BRBNS which could identify GI hemangiomas and extra intestinal lesions. On the contrast-enhanced CT images, the lesions were demonstrated by the thickening of bowel wall, nodular or irregular elevated lesions, soft-tissue masses, and enhancement in venous phase.…”

Anesthetic Implications of an Obstetric Patient with Blue Rubber Bleb Nevus Syndrome

“…Reported in 1:14,000 births, this syndrome is described typically as a sporadic genetic mutation, although there are case reports of autosomaldominant transmission. [3][4][5][6] Associated cutaneous lesions vary in size, shape, and color. Lesions are thin walled, and after compression, an empty sac slowly refills.…”