Blueberry extract decreases oxidative stress and improves functional parameters in lungs from rats with pulmonary arterial hypertension

Türck, Patrick; Fraga, Sara; Salvador, Isadora Schein; Carraro, Cristina Campos; Lacerda, Denise dos Santos; Bahr, Alan Christhian; Ortiz, Vanessa Duarte; Hickmann, Alexandre Roberto; Koetz, Mariana; Belló‐Klein, Adriane; Henriques, Amélia Teresinha; Agostini, Fabiana

doi:10.1016/j.nut.2019.110579

Cited by 29 publications

(21 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Folin-Ciocalteau reagent was used for the quantification of the phenolic compounds. Phenolic concentration was estimated by correlating the absorbance of the samples to a standard curve made with gallic acid, and the result was expressed as milligrams of gallic acid equivalents/gram extract (mg EAG/L of grape juice) [38].…”

Section: Phenolic Compounds Analysismentioning

confidence: 99%

“…We quantified the total flavonoids according the literature (MOR-ESCO et al, 2014). The concentration of flavonoids was estimated by correlating the absorbance of the samples to a standard curve performed with quercetin, in which the results were expressed as milligram equivalents of quercetin/gram extract (mg EQuerc/L of grape juice) [38]. The phenolic compounds isolated was performed by HPLC, with each standard (gallic acid, epigallocatechin, catechin, epicatechin, epigallocatechin gallate, rutin, ferulic acid, and resveratrol) [38].…”

Section: Phenolic Compounds Analysismentioning

confidence: 99%

See 1 more Smart Citation

Aquatic exercise associated or not with grape juice consumption-modulated oxidative parameters in Parkinson disease patients: A randomized intervention study

Oliveira

Pinheiro

Proença

et al. 2021

Heliyon

View full text Add to dashboard Cite

Parkinson's disease (PD) is a neurodegenerative disorder with significant motor disabilities and cognitive decline. Importantly, the imbalance of oxidative stress is related to PD physiopathology and progression. This study aimed to evaluate the impact of grape juice consumption associated with an aquatic exercise protocol on oxidative stress parameters and cognitive function in individuals with PD. The participants were randomized into two groups: grape juice group (GJG) and control group (CG) and were submitted to 4 weeks of an aquatic intervention (twice a week, approximately 60 minutes/session). The GJG also consumed 400 ml of grape juice per day (integral and conventional) during this period. Cognitive function was assessed by the Montreal Cognitive Assessment (MoCa) questionnaire. For the analysis of oxidative stress markers, specifically lipid oxidative damage (TBARS), proteins (Carbonil), acid uric and the activity of antioxidant enzymes (superoxide dismutase, glutathione peroxidase and catalase), blood collection were done before and after intervention. No changes were observed in cognitive function after intervention in both groups. Regarding biomarkers, a reduction of antioxidant enzymes, thiobarbituric acid reactive substances (TBARS) and uric acid was observed in both groups. However, only the GJG showed a significant reduction on protein oxidation levels after intervention. In conclusion, the consumption of grape juice associated with an aquatic exercise protocol might be consider an effective alternative to reduce the oxidative damage in PD, reinforcing the importance of this intervention in promoting beneficial impact in this population.

show abstract

Section: Phenolic Compounds Analysismentioning

confidence: 99%

Section: Phenolic Compounds Analysismentioning

confidence: 99%

Aquatic exercise associated or not with grape juice consumption-modulated oxidative parameters in Parkinson disease patients: A randomized intervention study

Oliveira

Pinheiro

Proença

et al. 2021

Heliyon

View full text Add to dashboard Cite

show abstract

“…Recently Rodriguez-Daza et al, (2020) revealed the key role of blueberry extract with proanthocynaidins in modulating the gut microbiota and restoring colonic epithelial mucus layer triggering health effects of blueberry polyphenols (Rodriguez-Daza et al, 2020). Moreover Türck, et al, (2020) evaluated the effect of blueberry extract on functional parameters and oxidative stress levels in rat lungs with pulmonary arterial hypertension (PAH) and reported that intervention with blueberry extract mitigated functional PAH outcomes through improvement of the pulmonary redox state (Türck et al, 2020). Tian et al, (2019) reported that cyanidin-3-arabinoside extracted from blueberry as a selective Protein Tyrosine Phosphatase 1B Inhibitor (PTP1B) which is an important target for type 2 diabetes (Tian et al, 2019).…”

Section: Health Benefitsmentioning

confidence: 99%

Bioactive Compounds, Antioxidant Activities, and Health Beneficial Effects of Selected Commercial Berry Fruits: A Review

Nemzer¹,

Kalita²,

Yashin³

et al. 2020

JFR

View full text Add to dashboard Cite

Epidemiological studies have provided the evidence that regular consumption of fruits and vegetables reduce the risk of pathological condition such as cardiovascular disease, cancer, inflammation, and aging. Among fruits, berries are considered as superfruits due to their highly packed phytochemicals comprising phenolic acids, flavonoids viz. flavonols, flavanols, and anthocyanins. These bioactive compounds are associated with significant antioxidant, antidiabetic, antiinflammation, and anticancer properties. This review highlights the basic information and interesting findings of some selected commercial berries with their phytochemical composition, antioxidant properties, and potential health benefits to human.

show abstract

“…Recently, blueberry extract was used in an experimental model of PAH induced by MCT (60 mg/kg, intraperitoneally) to evaluate its effects on functional parameters and antioxidant stress [ 195 ]. Rats were treated with blueberry extract at doses of 50, 100, and 200 mg/kg via gavage for five weeks (two weeks before MCT and three weeks after MCT injection).…”

Section: Nutraceuticals In the Treatment Of Pulmonary Arterial Hypmentioning

confidence: 99%

Nutraceuticals in the Treatment of Pulmonary Arterial Hypertension

Sánchez-Gloria

Osorio‐Alonso

Arellano‐Buendía

et al. 2020

IJMS

View full text Add to dashboard Cite

Pulmonary arterial hypertension (PAH) is a severe disease characterized by the loss and obstructive remodeling of the pulmonary arterial wall, causing a rise in pulmonary arterial pressure and pulmonary vascular resistance, which is responsible for right heart failure, functional decline, and death. Although many drugs are available for the treatment of this condition, it continues to be life-threatening, and its long-term treatment is expensive. On the other hand, many natural compounds present in food have beneficial effects on several cardiovascular conditions. Several studies have explored many of the potential beneficial effects of natural plant products on PAH. However, the mechanisms by which natural products, such as nutraceuticals, exert protective and therapeutic effects on PAH are not fully understood. In this review, we analyze the current knowledge on nutraceuticals and their potential use in the protection and treatment of PAH, as well as whether nutraceuticals could enhance the effects of drugs used in PAH through similar mechanisms.

show abstract

Blueberry extract decreases oxidative stress and improves functional parameters in lungs from rats with pulmonary arterial hypertension

Cited by 29 publications

References 61 publications

Aquatic exercise associated or not with grape juice consumption-modulated oxidative parameters in Parkinson disease patients: A randomized intervention study

Aquatic exercise associated or not with grape juice consumption-modulated oxidative parameters in Parkinson disease patients: A randomized intervention study

Bioactive Compounds, Antioxidant Activities, and Health Beneficial Effects of Selected Commercial Berry Fruits: A Review

Nutraceuticals in the Treatment of Pulmonary Arterial Hypertension

Contact Info

Product

Resources

About