Blueberry Metabolites Attenuate Lipotoxicity‐Induced Endothelial Dysfunction

Bharat, Divya; Cavalcanti, Rafaela Ramos Mororo; Petersen, Chrissa; Begaye, Nathan; Cutler, Brett; Costa, Marcella Melo Assis; Ramos, Renata Kelly Luna Gomes; Ferreira, Marina Ramos; Li, Youyou; Bharath, Leena P.; Toolson, Emma Louise; Sebahar, Paul R.; Looper, Ryan; Jalili, Thunder; Rajasekaran, Namakkal S.; Jia, Zhenquan; Symons, J. David; Babu, Pon Velayutham Anandh

doi:10.1002/mnfr.201700601

Cited by 63 publications

(60 citation statements)

References 48 publications

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“…Wild blueberry consumption is associated with glucose metabolism in metabolic syndrome obese rats [ 82 ]. The metabolism of blueberry anthocyanins lightens the endothelial dysfunction of lipid toxicity and lessens vascular complications associated with diabetes [ 55 ] (see Table 1 ). Blueberry can lighten vascular complications in diabetes as some of its metabolites can restore cell surface glycosaminoglycans and attenuate endothelial inflammation [ 83 ].…”

Section: Preventive Chronic Disease Of Blueberrymentioning

confidence: 99%

Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings

Sun

Zeng

et al. 2018

IJMS

125

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Functional ingredients in blueberry have the best health benefits. To obtain a better understanding of the health role of blueberry in chronic disease, we conducted systematic preventive strategies for functional ingredients in blueberry, based on comprehensive databases, especially PubMed, ISI Web of Science, and CNKI for the period 2008–2018. Blueberry is rich in flavonoids (mainly anthocyanidins), polyphenols (procyanidin), phenolic acids, pyruvic acid, chlorogenic acid, and others, which have anticancer, anti-obesity, prevent degenerative diseases, anti-inflammation, protective properties for vision and liver, prevent heart diseases, antidiabetes, improve brain function, protective lung properties, strong bones, enhance immunity, prevent cardiovascular diseases, and improve cognitive decline. The anthocyanins and polyphenols in blueberry are major functional ingredients for preventive chronic disease. These results support findings that blueberry may be one of the best functional fruits, and further reveals the mechanisms of anthocyanins and polyphenols in the health role of blueberry for chronic disease. This paper may be used as scientific evidence for developing functional foods, nutraceuticals, and novel drugs of blueberry for preventive chronic diseases.

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Section: Preventive Chronic Disease Of Blueberrymentioning

confidence: 99%

Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings

Sun

Zeng

et al. 2018

IJMS

125

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“…C3G possesses strong antioxidant activity potentially due to the two hydroxyls on the B ring [6], as shown in Figure 1. Recent studies have suggested that C3G potentially exerts functions primarily through C3G metabolites (C3G-Ms) [7], and more than 20 kinds of C3G-Ms have been identified in serum by a pharmacokinetics study in humans [8]. Although the function and mechanism of C3G-Ms are still not clear, protocatechuic acid (PCA) [9][10][11][12], phloroglucinaldehyde (PGA) [1], vanillic acid (VA) [13][14][15], ferulic acid (FA) [16][17][18][19], and their derivates represent the main bioactive metabolites of C3G due to their antioxidant and anti-inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity

et al. 2019

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Cyanidin-3-glucoside (C3G) is a well-known natural anthocyanin and possesses antioxidant and anti-inflammatory properties. The catabolism of C3G in the gastrointestinal tract could produce bioactive phenolic metabolites, such as protocatechuic acid, phloroglucinaldehyde, vanillic acid, and ferulic acid, which enhance C3G bioavailability and contribute to both mucosal barrier and microbiota. To get an overview of the function and mechanisms of C3G and its phenolic metabolites, we review the accumulated data of the absorption and catabolism of C3G in the gastrointestine, and attempt to give crosstalk between the phenolic metabolites, gut microbiota, and mucosal innate immune signaling pathways.

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“…After careful application of the inclusion and exclusion criteria to the citations collected with the databases search, the numbers of human studies selected for this review were 22 studies out of 206 for blueberry intake [ 2 , 3 , 12 , 13 , 32 , 34 , 37 , 50 , 81 – 83 , 91 , 103 , 105 , 106 , 112 , 137 , 153 , 160 , 178 , 185 ]; 20 out of 137 for strawberries [ 4 , 5 , 9 , 14 , 20 , 22 , 26 , 31 , 41 , 48 , 74 , 75 , 113 , 126 , 129 , 141 , 147 , 148 , 165 , 179 ], 7 out of 87 for raspberry [ 70 , 78 , 86 , 95 , 98 , 156 , 184 ], 5 out of 66 for blackberries [ 47 , 64 , 89 , 100 , 161 ], 13 out of 236 for cranberries [ 7 , 27 , 49 , 51 , 94 , 108 , 119 , 127 , 135 , 174 – 176 , 183 ], and 8 out of 61 for blackcurrant […”

Section: Resultsmentioning

confidence: 99%

Food intake biomarkers for berries and grapes

et al. 2020

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Grapes and berries are two types of widely consumed fruits characterized by a high content in different phytochemicals. However, their accurate dietary assessment is particularly arduous, because of the already wide recognized bias associated with self-reporting methods, combined with the large range of species and cultivars and the fact that these fruits are popularly consumed not only in fresh and frozen forms but also as processed and derived products, including dried and canned fruits, beverages, jams, and jellies. Reporting precise type and/or quantity of grape and berries in FFQ or diaries can obviously be affected by errors. Recently, biomarkers of food intake (BFIs) rose as a promising tool to provide accurate information indicating consumption of certain food items. Protocols for performing systematic reviews in this field, as well as for assessing the validity of candidate BFIs have been developed within the Food Biomarker Alliance (FoodBAll) Project. This paper aims to evaluate the putative BIFs for blueberries, strawberries, raspberries, blackberries, cranberries, blackcurrant, and grapes. Candidate BFIs for grapes were resveratrol metabolites and tartaric acid. The metabolites considered as putative BFI for berries consumption were mostly anthocyanins derivatives together with several metabolites of ellagitannins and some aroma compounds. However, identification of BFIs for single berry types encountered more difficulties. In the absence of highly specific metabolites reported to date, we suggested some multi-metabolite panels that may be further investigated as putative biomarkers for some berry fruits.

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Blueberry Metabolites Attenuate Lipotoxicity‐Induced Endothelial Dysfunction

Abstract: The presented findings indicate that the vascular benefits of blueberry anthocyanins are mediated by their metabolites. Blueberries might complement existing therapies to lessen vascular complications.

Cited by 63 publications

References 48 publications

Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings

Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings

The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity

Food intake biomarkers for berries and grapes

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