Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet–Fed Rats

Lee, Sun Hye; Keirsey, Katherine Iampietro; Kirkland, Rebecca A.; Grunewald, Zachary I.; Fischer, Joan G.; Serre, Claire B. de La

doi:10.1093/jn/nxx027

Cited by 187 publications

(217 citation statements)

References 67 publications

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“…On the other hand, anthocyanins are capable of modulating the growth of special intestinal bacteria [24] and increasing microbial abundances [64]. Anthocyanins have been reported to increase the relative abundance of beneficial bacteria such as Bifidobacterium and Akkermansia, which are believed to be closely related to anti-inflammatory effects [24,65].…”

Section: Crosstalk Between Gut Microbiota and C3gandc3g-msmentioning

confidence: 99%

“…In addition to the influence on gut microbiota, the inhibitory effect of anthocyanins on epithelial inflammation is another important factor that acts against intestinal injury [64,76]. Ferrari et al have demonstrated that the main protective effect of C3G in chronic gut inflammatory diseases is derived from the selective inhibition of the NF-κB pathway in epithelial cells [76].…”

Section: Anti-inflammatorymentioning

confidence: 99%

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The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity

et al. 2019

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Cyanidin-3-glucoside (C3G) is a well-known natural anthocyanin and possesses antioxidant and anti-inflammatory properties. The catabolism of C3G in the gastrointestinal tract could produce bioactive phenolic metabolites, such as protocatechuic acid, phloroglucinaldehyde, vanillic acid, and ferulic acid, which enhance C3G bioavailability and contribute to both mucosal barrier and microbiota. To get an overview of the function and mechanisms of C3G and its phenolic metabolites, we review the accumulated data of the absorption and catabolism of C3G in the gastrointestine, and attempt to give crosstalk between the phenolic metabolites, gut microbiota, and mucosal innate immune signaling pathways.

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Section: Crosstalk Between Gut Microbiota and C3gandc3g-msmentioning

confidence: 99%

Section: Anti-inflammatorymentioning

confidence: 99%

The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity

et al. 2019

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“…Eight‐week supplementation of wild blueberry powder to obese Zucker rats reduced plasma levels of pro‐inflammatory markers, including tumor necrosis factor alpha (TNFα), interleukin‐6 and C‐reactive protein, that are known to promote endothelial monocyte adhesion . Blueberry consumption reduced serum TNFα and Interleukin‐6, and downregulated aortic TNFα expression in apolipoprotein E‐deficient mice and reduced high‐fat diet–induced chronic inflammation in rats . In these animal studies, the anti‐inflammatory effects were tentatively attributed to the presence of blueberry polyphenols such as anthocyanins and/or proanthocyanidins .…”

Section: Introductionmentioning

confidence: 97%

Physiological Concentrations of Blueberry‐Derived Phenolic Acids Reduce Monocyte Adhesion to Human Endothelial Cells

Tang

Bozonet

McKenzie

et al. 2019

Molecular Nutrition Food Res

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Scope: Blueberry polyphenols are thought to confer cardiovascular health benefits, but have limited bioavailability. They undergo extensive metabolism and their phenolic acid metabolites are likely to be the mediators of bioactivity. The effect of blueberry-derived phenolic acids on one aspect of inflammation, monocyte adhesion to vascular endothelial cells, is investigated. Methods and results: The major blueberry-derived phenolic acids in human plasma are identified and quantified. Three test mixtures representing compounds present at 0-4 h (Early), 4-24 h (Late), or 0-24 h (Whole) are used to investigate the effect on adhesion of monocytes to tumor necrosis factor alpha (TNFα)-activated endothelial cells. The Late mixture reduces monocyte adhesion, but there is no effect of the Early or Whole mixtures. Exclusion of syringic acid from each mixture results in inhibition of monocyte adhesion. Exposure to the phenolic acid mixtures has no effect on the endothelial surface expression of adhesion molecules intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), or E-selectin, suggesting that other molecular mechanisms are responsible for the observed effect. Conclusion: This study shows that physiological concentrations of blueberry polyphenol metabolites can help maintain cardiovascular health by regulating monocyte adhesion to the vascular endothelium.

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“…With the critical roles of the gut microbiota and its communication with the gut-brain axis in the pathogenesis of obesity and metabolic complications, modulation of the gut microbiota composition has been an attractive target to prevent and/or treat those abnormalities [22][23][24]. In particular, since the diet has been associated with critical alterations in the gut microbiota [25], the use of non-invasive dietary approaches such as prebiotics in the presence of HF challenge have been reported to increase beneficial bacteria abundance, decrease local (gut, adipose) and systemic inflammation and preserve vagally-mediated satiety signaling, which is all associated with suppression of adiposity and weight gain [23,26,27]. the underlying mechanisms responsible for these metabolic benefits are not only via modulation of the host gut microbiota composition but also via associated changes in the production of microbial metabolites.…”

Section: Introductionmentioning

confidence: 99%

2′-Fucosyllactose Supplementation Improves Gut-Brain Signaling and Diet-Induced Obese Phenotype and Changes the Gut Microbiota in High Fat-Fed Mice

et al. 2020

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Obesity is characterized by fat accumulation, chronic inflammation and impaired satiety signaling, which may be due in part to gut microbial dysbiosis. Manipulations of the gut microbiota and its metabolites are attractive targets for obesity treatment. The predominant oligosaccharide found in human milk, acts as a prebiotic with beneficial effects on the host. However, little is known about the beneficial effects of 2′-FL in obesity. The aim of this study was to determine the beneficial effects of 2′-FL supplementation on the microbiota-gut-brain axis and the diet-induced obese phenotype in high fat (HF)-fed mice. Male C57/BL6 mice (n = 6/group; six weeks old) were counter-balanced into six weight-matched groups and fed either a low-fat (LF; 10% kcal as fat), HF (45% kcal as fat) or HF diet with 2′-FL (HF_2′-FL) at 1, 2, 5 and 10% (w/v) in drinking water for six weeks. General phenotypes (body weight, energy intake, fat and lean mass), cecal microbiome and metabolites, gut-brain signaling, intestinal permeability and inflammatory and lipid profiles were assessed. Only 10% 2′-FL, but not 1, 2 or 5%, decreased HF diet-induced increases in energy intake, fat mass and body weight gain. A supplementation of 10% 2′-FL changed the composition of cecal microbiota and metabolites compared to LF- and HF-fed mice with an increase in Parabacteroides abundance and lactate and pyruvate, respectively, whose metabolic effects corresponded to our study findings. In particular, 10% 2′-FL significantly reversed the HF diet-induced impairment of cholecystokinin-induced inhibition of food intake. Gene expressions of interleukin (IL)-1β, IL-6, and macrophage chemoattractant protein-1 in the cecum were significantly downregulated by 10% 2′-FL compared to the HF group. Furthermore, 10% 2′-FL suppressed HF diet-induced upregulation of hepatic peroxisome proliferator-activated receptor gamma, a transcription factor for adipogenesis, at the gene level. In conclusion, 10% 2′-FL led to compositional changes in gut microbiota and metabolites associated with improvements in metabolic profiles and gut-brain signaling in HF-fed mice. These findings support the use of 2′-FL for modulating the hyperphagic response to HF diets and improving the microbiota-gut-brain axis.

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Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet–Fed Rats

Abstract: In HF-diet-fed male rats, blueberry supplementation led to compositional changes in the gut microbiota associated with improvements in systemic inflammation and insulin signaling.

Cited by 187 publications

References 67 publications

The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity

The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity

Physiological Concentrations of Blueberry‐Derived Phenolic Acids Reduce Monocyte Adhesion to Human Endothelial Cells

2′-Fucosyllactose Supplementation Improves Gut-Brain Signaling and Diet-Induced Obese Phenotype and Changes the Gut Microbiota in High Fat-Fed Mice

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