This review paper covered stress, management related to asthma, trauma, sepsis, infl ammation along with anxiety, and depression that occurs both in women with asthma, traumatic children and adult patients. These areas, induce immune function changes, which can lead to both trauma and proinfl ammatory activation known as systemic infl ammation response syndrome (SIRS). Related to sepsis. Stress management in trauma is based upon the notion that stress causes an immune imbalance in susceptible individuals. Various topics also covered were the neuroimmune system, oxidative stress, infl ammation, innate immunity, the role of NF-kappa B related to infl ammation, cytokines, procalcitonin related to sepsis.