Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior

Trifilieff, Pierre; Ducrocq, Fabien; Veldt, Suzanne van der; Martínez, Diana

doi:10.1053/j.semnuclmed.2016.09.003

Cited by 41 publications

(38 citation statements)

References 193 publications

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“…Common to these constructs is a general ‘predisposition toward rapid, unplanned reactions to internal or external stimuli without regard to the negative consequences of these reactions’ (Moeller et al ., ). Impulsivity is recognized as a key component of several neuropsychiatric disorders (Moeller et al ., ; Lee et al ., ), including impulse control and substance use disorders (Mitchell & Potenza, ; Trifilieff et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Trait impulsiveness is related to smaller post‐commissural putamen volumes in males but not females

Caravaggio

Plitman

Chung

et al. 2017

Eur J of Neuroscience

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Impulsivity is considered a vulnerability trait for addiction. Recently, we found trait non-planning impulsiveness measured with the Karolinska Scales of Personality was negatively correlated with dopamine D receptor availability in the ventral striatum of healthy humans. While also observed in rodents, human studies have failed to find this association with other measures of trait impulsivity. We explored whether another rodent finding, reduced ventral striatum volume with greater impulsivity, could also be observed in humans using this scale. Non-planning impulsiveness was measured in 52 healthy subjects (21 female; mean age: 33.06 ± 9.69) using the Karolinska Scales of Personality. Striatal subregion volumes, including the globus pallidus, were acquired using the Multiple Automatically Generated Templates (MAGeT-Brain) algorithm. Although failing to support our a priori hypothesis, there was a significant sex interaction in the post-commissural putamen with impulsiveness. Exploratory analyses revealed impulsiveness was negatively correlated with post-commissural putamen volumes in males, but positively correlated in females. We replicated this finding in males in an increased sample (including all 52 previous subjects) who provided impulsiveness measured by the Temperament and Character Inventory (n = 73; 32 female; mean age: 33.48 ± 9.75). These correlations by sex were statistically different from one another, the main finding with the Kasolinksa Scales of Personality surviving correction for multiple comparisons. While impulsivity may be related to reduced ventral striatal D receptors across sexes, males but not females may show significant reductions in post-commissural putamen volume. These findings have important implications for understanding biological markers underlying sex differences in drug addiction vulnerability.

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Section: Introductionmentioning

confidence: 97%

Trait impulsiveness is related to smaller post‐commissural putamen volumes in males but not females

Caravaggio

Plitman

Chung

et al. 2017

Eur J of Neuroscience

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“…In turn, exposure to higher drug doses that further increases dopamine release also facilitates the neuroplastic changes that ultimately change the reactivity of brain dopamine pathways to drugs and drug cues [5]. This vicious cycle of increased tolerance, increased drug doses, and the neuroplastic changes they engender further perpetuate the downward spiral of increased consumption and associated severity of the addiction and drug dependence [25].…”

Section: Neuroplasticity and Tolerance: A Downward Spiralmentioning

confidence: 99%

“…This persistence in D2 receptor deficits suggests that these altered levels are not solely drug-induced [24]. Data from genetic studies suggest an important role for genetic factors that affect D2 receptor availability and may predict inter-individual responses to drugs of abuse [25]. For example, there are known mutations of the gene that encodes the D2 receptor, DRD2, that are linked to decreased expression of the D2 receptor, thereby decreasing their number.…”

Section: Excessive Midbrain Dopamine Activity Leads To Neuroplasticitmentioning

confidence: 99%

“…For example, there are known mutations of the gene that encodes the D2 receptor, DRD2, that are linked to decreased expression of the D2 receptor, thereby decreasing their number. It has been shown that these DRD2 mutation-produced D2 receptor deficiencies can exacerbate drug-induced D2 receptor abnormalities and predispose a patient to drug addiction [25].…”

Section: Excessive Midbrain Dopamine Activity Leads To Neuroplasticitmentioning

confidence: 99%

“…D2 receptors are involved in brain reward systems and underlie drug-induced cognitive impairments. Certain variants of this gene may lead to increased consumptive behaviors such as over-eating and increased propensity for drug abuse [24,25].…”

Section: Genetic Biomarkers Of Addiction Risk and Severitymentioning

confidence: 99%

See 2 more Smart Citations

Battling the Opiate Crisis: Translating the Latest Advances in Addiction Biology into Novel Treatment Strategies

Massey¹

2017

PPIJ

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The neurobiological reward system and binge eating: A critical systematic review of neuroimaging studies

Leenaerts

Jongen

Ceccarini

et al. 2022

Intl J Eating Disorders

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Objective Changes in reward processing are hypothesized to play a role in the onset and maintenance of binge eating (BE). However, despite an increasing number of studies investigating the neurobiological reward system in individuals who binge eat, no comprehensive systematic review exists on this topic. Therefore, this review has the following objectives: (1) identify structural and functional changes in the brain reward system, either during rest or while performing a task; and (2) formulate directions for future research. Methods A search was conducted of articles published until March 31, 2022. Neuroimaging studies were eligible if they wanted to study the reward system and included a group of individuals who binge eat together with a comparator group. Their results were summarized in a narrative synthesis. Results A total of 58 articles were included. At rest, individuals who binge eat displayed a lower striatal dopamine release, a change in the volume of the striatum, frontal cortex, and insula, as well as a lower frontostriatal connectivity. While performing a task, there was a higher activity of the brain reward system when anticipating or receiving food, more model‐free reinforcement learning, and more habitual behavior. Most studies only included one patient group, used general reward‐related measures, and did not evaluate the impact of comorbidities, illness duration, race, or sex. Discussion Confirming previous hypotheses, this review finds structural and functional changes in the neurobiological reward system in BE. Future studies should compare disorders, use measures that are specific to BE, and investigate the impact of confounding factors. Public Significance Statement This systematic review finds that individuals who binge eat display structural and functional changes in the brain reward system. These changes could be related to a higher sensitivity to food, relying more on previous experiences when making decisions, and more habitual behavior. Future studies should use a task that is specific to binge eating, look across different patient groups, and investigate the impact of comorbidities, illness duration, race, and sex.

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Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior

Cited by 41 publications

References 193 publications

Trait impulsiveness is related to smaller post‐commissural putamen volumes in males but not females

Trait impulsiveness is related to smaller post‐commissural putamen volumes in males but not females

Battling the Opiate Crisis: Translating the Latest Advances in Addiction Biology into Novel Treatment Strategies

The neurobiological reward system and binge eating: A critical systematic review of neuroimaging studies

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