Blunted hemodynamic and hormonal responses to tilt-test in patients with sickle-cell disease

Romero-Vecchione, Eduardo; Vásquez, J; Pérez, Omidres; Antequera, Rafael

doi:10.1016/s0531-5131(01)00584-2

Cited by 2 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first work investigating ANS activity in this population demonstrated abnormalities in cardiovascular ANS function of SCD patients compared to normal white and normal black controls [53]. Then, Romero-Vecchione et al [54] demonstrated abnormal responses of SCD patients during a tilt-test in comparison with controls. In baseline condition, SCD patients exhibit autonomic imbalance caused by a reduced parasympathetic activity compared to controls [55].…”

Section: Evidence Of Autonomic Nervous System Dysfunction In Sickle C...mentioning

confidence: 97%

Autonomic nervous system dysfunction: Implication in sickle cell disease

Connes

Coates

2012

Comptes Rendus. Biologies

View full text Add to dashboard Cite

Sickle cell disease is an inherited hemoglobinopathy caused by a single amino acid substitution in the b chain of hemoglobin that causes the hemoglobin to polymerize in the deoxy state. The resulting rigid, sickle-shaped red cells obstruct blood flow causing hemolytic anemia, tissue damage, and premature death. Hemolysis is continual. However, acute exacerbations of sickling called vaso-occlusive crises (VOC) resulting in severe pain occur, often requiring hospitalization. Blood rheology, adhesion of cellular elements of blood to vascular endothelium, inflammation, and activation of coagulation decrease microvascular flow and increase likelihood of VOC. What triggers the transition from steady state to VOC is unknown. This review discusses the interaction of blood rheological factors and the role that autonomic nervous system (ANS) induced vasoconstriction may have in triggering crisis as well as the mechanism of ANS dysfunction in SCD.ß 2012 Published by Elsevier Masson SAS on behalf of Acade ´mie des sciences.

show abstract

Section: Evidence Of Autonomic Nervous System Dysfunction In Sickle C...mentioning

confidence: 97%

Autonomic nervous system dysfunction: Implication in sickle cell disease

Connes

Coates

2012

Comptes Rendus. Biologies

View full text Add to dashboard Cite

show abstract

“…Studies suggest that there are some degrees of cardiovascular autonomic dysfunction among SCA patients and sickle cell trait carriers (Connes et al 2006, Romero Mestre et al 1997, Romero-Vecchione et al 1995, Pearson et al 2005. Although acute atherosclerosisrelated myocardial infarctions are rare in SCA patients, diverse cardiovascular anomaliesincluding heart murmur, cardiomegaly, biventricular hypertrophy and abnormalities in the cardiac conducting system-which sometimes correlate to sudden death in SCA patients, have been described by multiple researchers (James et al 1994, Assanasen et al 2003, Norris et al 1991, Pavlu et al 2007, Manci et al 2003, Batra et al 2002.…”

Section: Introductionmentioning

confidence: 99%

Abnormal autonomic cardiac response to transient hypoxia in sickle cell anemia

2008

View full text Add to dashboard Cite

The objective of this study was to non-invasively assess cardiac autonomic control in subjects with sickle cell anemia (SCA) by tracking the changes in heart rate variability (HRV) that occur following brief exposure to a hypoxic stimulus. Five African-American SCA patients and seven healthy control subjects were recruited to participate in this study. Each subject was exposed to a controlled hypoxic stimulus consisting of five breaths of nitrogen. Time-varying spectral analysis of HRV was applied to estimate the cardiac autonomic response to the transient episode of hypoxia. The confounding effects of changes in respiration on the HRV spectral indices were reduced by using a computational model. A significant decrease in the parameters related to parasympathetic control was detected in the post-hypoxic responses of the SCA subjects relative to normal controls. The spectral index related to sympathetic activity, on the other hand, showed a tendency to increase the following hypoxic stimulation, but the change was not significant. This study suggests that there is some degree of cardiovascular autonomic dysfunction in SCA that is revealed by the response to transient hypoxia.

show abstract

Blunted hemodynamic and hormonal responses to tilt-test in patients with sickle-cell disease

Cited by 2 publications

References 8 publications

Autonomic nervous system dysfunction: Implication in sickle cell disease

Autonomic nervous system dysfunction: Implication in sickle cell disease

Abnormal autonomic cardiac response to transient hypoxia in sickle cell anemia

Contact Info

Product

Resources

About