Blunted hypothalamic‐pituitary‐adrenal axis and insulin response to psychosocial stress in young adults born preterm at very low birth weight

Kaseva, Nina; Wehkalampi, Karoliina; Pyhälä, Riikka; Moltchanova, Elena; Feldt, Kimmo; Pesonen, Anu‐Katriina; Heinonen, Kati; Hovi, Petteri; Järvenpää, Anna‐Liisa; Andersson, Sture; Eriksson, Johan G.; Räikkönen, Katri; Kajantie, Eero

doi:10.1111/cen.12251

Cited by 40 publications

(49 citation statements)

References 28 publications

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“…School aged children born very preterm or with very-low-birth-weight (VLBW; < 1500 g) show lower diurnal cortisol profiles (Wadsby et al, 2014), faster decreasing cortisol levels in the evening , and decreased salivary cortisol responses to social stress (Buske-Kirschbaum et al, 2007), which is also consistent with findings in adults (Kaseva et al, 2014). Relatedly, boys born very preterm exposed to more distressing medical procedures had lower diurnal cortisol levels at age 7 (Brummelte et al, 2015).…”

Section: Maurersupporting

confidence: 67%

“…Studies with children born very preterm and animal models of early life adversities show similar HPA axis alterations -often involving persistent down-regulation of HPA axis activity (Feng et al, 2011;Kaseva et al, 2014). School aged children born very preterm or with very-low-birth-weight (VLBW; < 1500 g) show lower diurnal cortisol profiles (Wadsby et al, 2014), faster decreasing cortisol levels in the evening , and decreased salivary cortisol responses to social stress (Buske-Kirschbaum et al, 2007), which is also consistent with findings in adults (Kaseva et al, 2014).…”

Section: Maurersupporting

confidence: 65%

“…However, there are also conflicting data. For example, preterm born children were found to exhibit no differences regarding morning (Brummelte et al, 2015;Perkinson-Gloor et al, 2015), evening (Quesada et al, 2014), and diurnal cortisol profiles (Buske-Kirschbaum et al, 2007;Kaseva et al, 2014) and salivary cortisol responses to social stress (Brummelte et al, 2015;Buske-Kirschbaum et al, 2007), or even higher salivary cortisol levels at awakening (Buske-Kirschbaum et al, 2007;Quesada et al, 2014).…”

Section: Maurermentioning

confidence: 99%

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Salivary and hair glucocorticoids and sleep in very preterm children during school age

Maurer

Perkinson-Gloor

Stalder

et al. 2016

Psychoneuroendocrinology

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Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP url' above for details on accessing the published version and note that access may require a subscription. measures in very preterm children during school-age is rare. Eighty-five healthy children born very preterm (<32nd gestational week) and 91 full-term children aged 7-12 years were recruited for the present study. To assess HPA axis activity, salivary cortisol was measured at awakening, 10, 20, and 30 min later. In addition, hair cortisol and cortisone concentrations were quantified using liquid chromatography tandem mass spectrometry to assess cumulative endocrine activity over the preceding months. One night of in-home polysomnographic sleep assessment was conducted to assess sleep duration, sleep continuity, and sleep architecture. Children born very preterm showed significantly lower levels of cortisol at awakening and lower overall post-awakening cortisol secretion, lower cortisone in hair, and earlier sleep onset than full-term children. Across the whole sample, overall postawakening cortisol secretion was positively related to sleep onset time and negatively to sleep duration.The association between prematurity status and post-awakening cortisol secretion was partially mediated by earlier sleep onset time. In conclusion, this study provides evidence for a possible downregulation of the HPA axis activity and slightly earlier sleep phase in very preterm children during school age.

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Section: Maurersupporting

confidence: 67%

Section: Maurersupporting

confidence: 65%

Section: Maurermentioning

confidence: 99%

See 1 more Smart Citation

Salivary and hair glucocorticoids and sleep in very preterm children during school age

Maurer

Perkinson-Gloor

Stalder

et al. 2016

Psychoneuroendocrinology

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“…2 The underlying biological mechanisms remain unclear. In the same cohort, the VLBW adults had lower hypothalamic-pituitary-adrenal axis responses 31 and similar or lower norepinephrine responses 32 to psychosocial stress, arguing against a major role of these systems in mediating BP levels or variability in adults born preterm. 33 Additional possible mechanisms include smaller kidney size 34 and number of nephrons 35 or arterial stiffness.…”

Section: Discussionmentioning

confidence: 94%

“…In the same cohort, the VLBW adults had lower hypothalamic-pituitary-adrenal axis responses 31 and similar or lower norepinephrine responses 32 to psychosocial stress, arguing against a major role of these systems in mediating BP levels or variability in adults born preterm. Common genetic origins of preterm birth and high BP remain a possibility.…”

Section: Sipola-leppänen Et Al Ambulatory Blood Pressure In Adults Bomentioning

confidence: 93%

Ambulatory Blood Pressure and Its Variability in Adults Born Preterm

et al. 2015

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A pproximately 14.9 million babies (11% of all infants born) worldwide are born preterm (<37 weeks) every year.1 Adults born preterm with very low birth weight (VLBW; <1500 g) or very (<32 weeks) or early (<34 weeks) preterm have higher blood pressure (BP) 2-6 and higher rates of hypertension compared with their peers born at term. There is some evidence of a continuous relationship between shorter length of gestation and higher BP. 7,8 Although most studies have relied on office-measured BP, we are aware of 5 studies that used 24-hour ambulatory BP (ABP) in adults born preterm. Those studies show either elevated BP 9-13 or hypertension, 9 and all are limited to adults born preterm at VLBW or very or extremely (<28 weeks) preterm, comprising the extreme 1% to 1.5% of newborns. Although 24-hour ABP predicts cardiovascular events better than office-measured BP, 14,15 it has not been studied across the entire range of preterm births.In addition to mean BP levels, previous studies have highlighted BP variability as a key factor underlying the progression of organ damage 16 and triggering vascular events. 15 It is also correlated with the development of hypertensive left ventricular hypertrophy. 17 BP variability is studied less often in adults born preterm. We hypothesized that preterm birth, across its entire range, is associated with elevated levels and larger variability of ABP in young adults. MethodsThis study is part of the ESTER (Preterm Birth and Early Life Programming of Adult Health and Disease) study, 18 a case-cohort study with subjects recruited through Northern Finland Birth Cohort Abstract-Adults born preterm have higher blood pressure (BP) than those born at term. Most studies have focused on preterm birth, and few have assessed BP variability, an independent risk factor of cardiovascular disease. We studied the association of preterm birth with 24-hour ambulatory BP, measured by an oscillometric device, in 42 young adults born early preterm (<34 weeks), 72 born late preterm (34-36 weeks), and 103 controls (≥37 weeks). Sleep was confirmed with accelerometry in 72.4% of subjects. The 24-hour systolic BP of adults born early preterm was 5.5 mm Hg higher (95% confidence interval, 1.9-9.3), awake systolic BP was 6.4 mm Hg higher (95% confidence interval, 2.8-10.1), and sleeping systolic BP was 2.9 mm Hg higher (95% confidence interval 0.3-7.5) when adjusted for age, sex, and use of accelerometry. The differences remained similar when adjusted for height, body mass index, physical activity, smoking, parental education, maternal body mass index, smoking during pregnancy, and gestational diabetes mellitus and attenuated slightly when adjusted for maternal hypertensive pregnancy disorders. Adults born early preterm also had higher BP variability as indicated by higher individual standard deviations of systolic BP and diastolic BP. Although our results were consistent with a dose-response relationship between shorter gestation and higher BP, the difference between the late preterm and term groups was not ...

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Linking extremely low birth weight and internalizing behaviors in adult survivors: Influences of neuroendocrine dysregulation

Waxman

Lieshout

Boyle

et al. 2015

Developmental Psychobiology

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Young adult survivors of extremely low birth weight (ELBW; <1000 g) are known to be at elevated risk for internalizing problems, though little is known about the mechanisms that may lead to higher levels of psychopathology in this vulnerable group. We examined the moderating influence of neuroendocrine functioning on the link between being born at ELBW and internalizing behaviors at age 30-35. Salivary cortisol was collected 20 min after completion of a social stress task in 83 ELBW adult survivors and 89 normal birth weight (NBW; >2500 g) controls. Using a median split, participants were separated into two groups (high or low afternoon cortisol levels). ELBW survivors with "high" afternoon cortisol levels self-reported significantly higher levels of internalizing behaviors compared to those with "low" afternoon cortisol levels. This association between afternoon cortisol and internalizing symptoms did not exist among NBW controls. These results are suggestive of a differential susceptibility for internalizing behaviors among ELBW survivors, depending on their ability to regulate neuroendocrine responses.

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Blunted hypothalamic‐pituitary‐adrenal axis and insulin response to psychosocial stress in young adults born preterm at very low birth weight

Abstract: VLBW adults have lower HPAA responses to psychosocial stress than term-born controls. This is accompanied by a lower insulin response.

Cited by 40 publications

References 28 publications

Salivary and hair glucocorticoids and sleep in very preterm children during school age

Salivary and hair glucocorticoids and sleep in very preterm children during school age

Ambulatory Blood Pressure and Its Variability in Adults Born Preterm

Linking extremely low birth weight and internalizing behaviors in adult survivors: Influences of neuroendocrine dysregulation

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