Blunted local but preserved remote vascular responses after resistance exercise in chronic heart failure

Guindani, Grace; Umpierre, Daniel; Grigoletti, Shana Souza; Vaz, Marco Aurélio; Stein, Ricardo; Ribeiro, Jorge Pinto

doi:10.1177/1741826711418931

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…Previous studies show that a typical exercise session for CHF patients lasts 60 min, which is divided into 40 min of aerobic exercise, 15 min of resistance exercise and 5-10 min of stretching [3,14,26]. The answer to the conflict between our findings and other studies [16] may be due to the patient's clinical and physical characteristics. Peak VO 2 and ejection fraction are lower in our patients, which implies that we are dealing with sicker patients.…”

Section: Mice Hiiecontrasting

confidence: 80%

“…Note that neither MICE nor HIIE caused significant changes in FBF and FVC. Previous studies demonstrated that an acute bout of exercise increased muscle blood flow in healthy individuals [18] and heart failure patients [16]. Thus, increase in FBF should be expected in our study.…”

supporting

confidence: 59%

“…Peak VO 2 and ejection fraction are lower in our patients, which implies that we are dealing with sicker patients. In addition, leg bicycle exercise was performed in our study, whereas strength exercise was conducted in Guindani's study [16]. It is unlikely that the time recording after exercise explains the difference in muscle blood flow between our study and others [13].…”

Section: Mice Hiiementioning

confidence: 65%

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Post-Exercise Neurovascular Control in Chronic Heart Failure Patients

et al. 2016

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It remains unknown whether or not a reduction in muscle sympathetic nerve activity in heart failure patients is associated over time with the effects of long- or short-term repeated exercise. 10 chronic heart failure patients, age 49±3 years old, functional class I-III NYHA, ejection fraction <40% were randomly submitted to either an acute bout of moderate continuous exercise OR high-intensity interval exercise. Muscle sympathetic nerve activity (microneurography) and forearm blood flow (venous occlusion plethysmography) were evaluated pre- and post-exercise sessions. The moderate exercise consisted of cycle exercise at an intensity corresponding to anaerobic threshold. The interval exercise consisted of a 2-min cycle exercise at intensity corresponding to anaerobic threshold, followed by a 1-min exercise set at respiratory compensation point. Exercise capacity was evaluated by cardiopulmonary exercise test. The caloric expenditure in both sessions was 100 kcal. Baseline muscle sympathetic nerve activity and forearm blood flow levels were not different between sessions. Moderate or high-intensity exercise caused no significant changes in muscle sympathetic nerve activity and forearm blood flow. These findings suggest that the reduction in muscle sympathetic nerve activity and the increase in forearm blood flow provoked by exercise training in chronic heart failure patients are due to cumulative effects over time.

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Section: Mice Hiiecontrasting

confidence: 80%

supporting

confidence: 59%

Section: Mice Hiiementioning

confidence: 65%

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Post-Exercise Neurovascular Control in Chronic Heart Failure Patients

et al. 2016

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“…Although there is no previous publication concerning subacute effect of an exercise session on endothelial function in patients with HFpEF, previous studies have evaluated patients with heart failure with reduced ejection fraction in a similar context. 35 , 36 Those participants responded to a single cycling exercise session with improved forearm endothelium-dependent vasodilation (reactive hyperemia) evaluated by plethysmography up to 30 minutes after exercise. 35 Currie et al 20 evaluated coronary artery disease patients after one single HIIT session and found an increase in the endothelial function after 60 minutes.…”

Section: Discussionmentioning

confidence: 99%

Vasodilation and Reduction of Systolic Blood Pressure after One Session of High-Intensity Interval Training in Patients With Heart Failure with Preserved Ejection Fraction

Lima

Silveira

Saffi

et al. 2018

Arquivos Brasileiros De Cardiologia

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BackgroundHeart failure with preserved ejection fraction (HFpEF) is a multifactorial syndrome characterized by a limited exercising capacity. High-intensity interval training (HIIT) is an emerging strategy for exercise rehabilitation in different settings. In patients with HFpEF, HIIT subacute effects on endothelial function and blood pressure are still unknown.ObjectiveTo evaluate the subacute effect of one HIIT session on endothelial function and blood pressure in patients with HFpEF.MethodsSixteen patients with HFpEF underwent a 36-minute session of HIIT on a treadmill, alternating four minutes of high-intensity intervals with three minutes of active recovery. Brachial artery diameter, flow-mediated dilation, and blood pressure were assessed immediately before and 30 minutes after the HIIT session. In all analyses, p <0.05 was considered statistically significant.ResultsThere was an increase in brachial artery diameter (pre-exercise: 3.96 ± 0.57 mm; post-exercise: 4.33 ± 0.69 mm; p < 0.01) and a decrease in systolic blood pressure (pre-exercise: 138 ± 21 mmHg; post-exercise: 125 ± 20 mmHg; p < 0.01). Flow-mediated dilation (pre-exercise: 5.91 ± 5.20%; post-exercise: 3.55 ± 6.59%; p = 0.162) and diastolic blood pressure (pre-exercise: 81 ± 11 mmHg; post-exercise: 77 ± 8 mmHg; p = 1.000) did not change significantly. There were no adverse events throughout the experiment.ConclusionsOne single HIIT session promoted an increase in brachial artery diameter and reduction in systolic blood pressure, but it did not change flow-mediated dilation and diastolic blood pressure.

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“…Exercise effects on BF and RH seem to be systemically mediated, since a previous study with healthy subjects and chronic heart failure patients showed an increase in BF and RH measured in the forearm after resistance leg exercise (Guindani et al 2012). In addition, in healthy subjects, BF also increased after exercise performed with the muscles where BF was measured (Guindani et al 2012;Willoughby et al 2011). However, as patients with PAD presented BF and RH impairment during exercise with affected limb, responses should be different in these patients if only lower-limb exercises were employed, which should be tested in the future.…”

Section: Peripheral Vasodilatadormentioning

confidence: 91%

A session of resistance exercise increases vasodilation in intermittent claudication patients

Andrade-Lima

Ritti‐Dias

Forjaz

et al. 2015

Appl. Physiol. Nutr. Metab.

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No study has shown the effects of acute resistance exercise on vasodilatory capacity of patients with peripheral artery disease. The aim of this study was to analyse the effects of a single session of resistance exercise on blood flow, reactive hyperemia, plasma nitrite, and plasma malondialdehyde in patients with peripheral artery disease. Fourteen peripheral artery disease patients underwent, in a random order, 2 experimental sessions: control (rest for 30 min) and resistance exercise (8 exercises, 2 sets of 10 repetitions at an intensity of 5-7 in the OMNI Resistance Exercise Scale). Blood flow, reactive hyperemia, plasma nitrite, and malondialdehyde were measured before and 40 min after the interventions in both sessions. Data were compared between sessions by analysis of covariance, using pre-intervention values as covariates. The increases in blood flow, reactive hyperemia, and log plasma nitrite were greater (p ≤ 0.05) after resistance exercise than the control session (3.2 ± 0.1 vs. 2.7 ± 0.1 mL · 100 mL(-1) tissue · min(-1), 8.0 ± 0.1 vs. 5.7 ± 0.1 AU, and 1.36 ± 0.01 vs. 1.26 ± 0.01 μmol ∙ L(-1), respectively). On the other hand, malondialdehyde was similar between sessions (p > 0.05). In peripheral arterial disease patients, a single session of resistance exercise increases blood flow and reactive hyperemia, which seems to be mediated, in part, by increases in nitric oxide release.

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Blunted local but preserved remote vascular responses after resistance exercise in chronic heart failure

Abstract: Patients with CHF present blunted vascular responses in the exercised areas, but remote vascular reactivity responses are similar to those observed in healthy individuals, suggesting that resistance exercise may remotely contribute to vascular adaptation in nontrained vasculatures.

Cited by 8 publications

References 35 publications

Post-Exercise Neurovascular Control in Chronic Heart Failure Patients

Post-Exercise Neurovascular Control in Chronic Heart Failure Patients

Vasodilation and Reduction of Systolic Blood Pressure after One Session of High-Intensity Interval Training in Patients With Heart Failure with Preserved Ejection Fraction

A session of resistance exercise increases vasodilation in intermittent claudication patients

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