Blunted Overnight Blood Pressure Dipping in Second Trimester; A Strong Predictor of Gestational Hypertension and Preeclampsia

Saremi, A.T.; Shafiee, Mohammad A.; Montazeri, Mahdi; Rashidi, Negin; Montazeri, Mohammad

doi:10.2174/1573402114666180924143801

Cited by 12 publications

(4 citation statements)

References 17 publications

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“…However, it was found that pattern of daily changes in BP conveyed significant additional information about the severity of the disease and related complications. Disrupted dipping pattern was associated with renal end-organ damage [17], progression of coronary artery disease [18], cerebrovascular event risk [19] and hypertension-related complications in pregnancy [20]. As a result, wide clinical use and standardization of ambulatory blood pressure monitorization was rigorously proposed [21].…”

Section: Discussionmentioning

confidence: 99%

Plasma catestatin importance and correlation in patients with dipper and non-dipper hypertension patients

Topal¹,

Mutluer²,

Akgumus³

et al. 2022

Med-Science

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Catestatin (CST) is a metabolite of chromogranin A, a soluble protein in catecholamine storage vesicles acting as a feedback inhibitor of catecholamine secretion. This study aims to investigate the correlation of catestatin with dipper and non-dipper status in hypertensive patients. Hypertensive (n=355) and healthy subjects (n=129) were randomly selected at an outpatient clinic. Blood pressure and heart rate were measured according to relevant guidelines. Plasma catestatin level, plasma glucose, lipid levels were measured. An ambulatory blood pressure monitor was performed to determine the dipping patterns in hypertensive subjects. Univariate and multivariate analyses were conducted to assess factors affecting catestatin levels. Left ventricular mass was higher among hypertensives compared with healthy controls (178±47 g versus 213±52 g in healthy controls and hypertensives, p<0.05), but there was no significant difference between the two hypertensive groups 205±43 g versus 228±77 g in dippers versus non-dippers, p=0.54). Average systolic blood pressure (SBP) and the percentage of systolic blood pressure dipping were statistically significantly negative correlated with CST (r=-0.316, p<0.05 for systolic dipping%, r=-0.283, p<0.05 for ASBP). In multivariate analysis for the prediction of catestatin levels, systolic dipping % and mean SBP were found to be independent predictors of plasma catestatin level. Plasma catestatin levels were lower among hypertensives compared to healthy controls and modest inverse correlations between catestatin and dipping percentage of systolic blood pressure and also between catestatin and average systolic blood pressure were noted. In hypertensive subjects, lower plasma catestatin levels may alert clinicians to the non-dipping status of the blood pressure.

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Section: Discussionmentioning

confidence: 99%

Plasma catestatin importance and correlation in patients with dipper and non-dipper hypertension patients

Topal¹,

Mutluer²,

Akgumus³

et al. 2022

Med-Science

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“…ScottCare software automatically scores BP readings and calculates average daytime and nighttime SBP and DBP, daytime and nighttime BP variability (i.e., the standard deviation of BP readings throughout a 24‐hr period), and BP dipping (i.e., a difference of more than 10% between mean daytime and nighttime BP). Loss of BP dipping is an early sign of preeclampsia (Saremi et al., 2019). ABPM was considered valid if 15 or more measurements were captured.…”

Section: Methodsmentioning

confidence: 99%

Posttraumatic stress disorder, diurnal cortisol, and ambulatory blood pressure in early and late pregnancy

Bublitz

Nillni

Nugent

et al. 2022

Journal of Traumatic Stress

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Posttraumatic stress disorder (PTSD) affects 1 in 20 reproductive-aged women and is associated with cardiovascular disease morbidity and mortality. The pathophysiology linking PTSD to cardiovascular disease in nonpregnant adults is proposed to include hypothalamic and autonomic dysregulation; however, the pathways explaining this association in pregnancy are unclear. We examined diurnal cortisol and ambulatory blood pressure (BP) among 254 pregnant women at approximately 12 and 32 gestational weeks. Participants were, on average, 31 years old (SD = 5), 24.4% reported their ethnicity as Hispanic, and 62.2% reported their race as White. PTSD symptoms were measured using the PTSD Checklist for DSM-5 (PCL-5). Hierarchical linear regression analyses were performed to examine associations pregnancy between PTSD and cortisol at awakening, 30 min after awakening, and bedtime in early and late pregnancy, as well as associations between PTSD symptoms and daytime and nighttime systolic (SBP) and diastolic BP (DBP) and BP variability. Logistic regression analyses were conducted to test associations between PTSD symptoms and BP dipping. The results showed a positive association between PTSD symptoms and nighttime BP and BP variability at 32 gestational weeks, ∆R 2 = .036-.067. PTSD symptoms were negatively associated with awakening cortisol at 12 gestational weeks in unadjusted models. These findings contribute to understanding the associations between PTSD and adverse cardiovascular conditions in pregnancy. More research is needed to replicate these findings and examine whether PTSD interventions are effective at modifying pathways and decreasing the risk for cardiovascular complications in pregnancy.

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“…107 A strong association has been reported between attenuated dipping of BP at night during the second trimester and subsequent development of preeclampsia in the third trimester. 108…”

Section: Common Mechanisms Underlying Nondipping and Morning Bp Surgementioning

confidence: 99%

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

Faraci,

Scheer

2024

Circulation Research

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Hypertension is extremely common, affecting approximately 1 in every 2 adults globally. Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and premature mortality worldwide. Despite considerable efforts to define mechanisms that underlie hypertension, a potentially major component of the disease, the role of circadian biology has been relatively overlooked in both preclinical models and humans. Although the presence of daily and circadian patterns has been observed from the level of the genome to the whole organism, the functional and structural impact of biological rhythms, including mechanisms such as circadian misalignment, remains relatively poorly defined. Here, we review the impact of daily rhythms and circadian systems in regulating blood pressure and the onset, progression, and consequences of hypertension. There is an emphasis on the impact of circadian biology in relation to vascular disease and end-organ effects that, individually or in combination, contribute to complex phenotypes such as cognitive decline and the loss of cardiac and brain health. Despite effective treatment options for some individuals, control of blood pressure remains inadequate in a substantial portion of the hypertensive population. Greater insight into circadian biology may form a foundation for novel and more widely effective molecular therapies or interventions to help in the prevention, treatment, and management of hypertension and its related pathophysiology.

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Blunted Overnight Blood Pressure Dipping in Second Trimester; A Strong Predictor of Gestational Hypertension and Preeclampsia

Cited by 12 publications

References 17 publications

Plasma catestatin importance and correlation in patients with dipper and non-dipper hypertension patients

Plasma catestatin importance and correlation in patients with dipper and non-dipper hypertension patients

Posttraumatic stress disorder, diurnal cortisol, and ambulatory blood pressure in early and late pregnancy

Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure

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