2022
DOI: 10.3389/fneur.2022.843081
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Blunted Post-COVID-19 Humoral Immunity in Patients With CNS Demyelinating Disorders on Anti-CD20 Treatments

Abstract: With unclear characteristics of post-infection and post-vaccination immunity, the multiple sclerosis community lacks evidence to guide patients on their continued coronavirus disease 2019 (COVID-19) infection risk. As disease modifying treatments all modulate the immune system, we expect their use to alter acquired immunity to COVID-19, but the specific impact of individual treatments is unclear. To address this, we analyzed the patient and COVID-19 specific characteristics associated with post-infection humor… Show more

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“…Immunomodulatory therapy may induce a blunted humoral response to SARS-CoV-2 infection and reduce the response to vaccination [ 52 , 53 ].…”
Section: Discussionmentioning
confidence: 99%
“…Immunomodulatory therapy may induce a blunted humoral response to SARS-CoV-2 infection and reduce the response to vaccination [ 52 , 53 ].…”
Section: Discussionmentioning
confidence: 99%