1985
DOI: 10.1213/00000539-198512000-00001
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Blunting of Stress Responses in the Pulmonary Circulation of Infants by Fentanyl

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Cited by 139 publications
(69 citation statements)
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“…In addition, a reduction in positive end-expiratory pressure during ETT suction may increase recruitment of pulmonary arterioles and thus increase left-to-right shunting across the ductus arteriosus in the LPS-exposed lambs, which displayed a higher PVR than controls before ETT suction. Open ETT suction increases P MPA in human neonates (26). Our data from preterm lambs are consistent, showing that open ETT suction increased P MPA ; however, the increase tended to be greater in LPS-exposed lambs as compared with controls.…”
Section: Chorioamnionitis Alters Hemodynamicssupporting
confidence: 79%
“…In addition, a reduction in positive end-expiratory pressure during ETT suction may increase recruitment of pulmonary arterioles and thus increase left-to-right shunting across the ductus arteriosus in the LPS-exposed lambs, which displayed a higher PVR than controls before ETT suction. Open ETT suction increases P MPA in human neonates (26). Our data from preterm lambs are consistent, showing that open ETT suction increased P MPA ; however, the increase tended to be greater in LPS-exposed lambs as compared with controls.…”
Section: Chorioamnionitis Alters Hemodynamicssupporting
confidence: 79%
“…Some studies suggest that nitrous oxide as a supplemental anaesthetic agent may increase PVR, especially in those with pre-existing elevated PVR [44], and it may also adversely influence endothelial function [45]. An increase in adverse cardiovascular events following its use in major surgery has been observed [46], possibly also through adverse pulmonary vascular effects of increased sympathomimetic stimulation [47,48] or hypoxia [49], and a study addressing these questions is ongoing [50].…”
Section: Discussionmentioning
confidence: 99%
“…20 Hypoxemia seems to be related either to apnea at the time of intubation or possible airway obstruction associated with positioning. 17 Bradycardia is presumed to be vagal in origin, because the very rapid onset is suggestive of a reflexive etiology 17 and is not prevented by preoxygenation and the avoidance of hypoxemia.…”
Section: Physiologic Responses To Intubationmentioning
confidence: 99%
“…19,21 Systemic arterial hypertension has been investigated in adults and seems to be caused by an increase in systemic vascular resistance, which is probably caused by catecholamine release. 22 Pulmonary hypertension leading to right ventricular failure has been described in adults, 23 and although pulmonary artery pressures have not been measured in newborn infants undergoing intubation, endotracheal suctioning is known to cause an increase in pulmonary artery pressure postoperatively in infants with congenital heart disease 20 and is presumed to occur with intubation. In addition, improperly performed direct laryngoscopy can cause traumatic injuries to the face, eyes, tongue, and gums, and placement of the endotracheal tube can dislodge the arytenoids or damage other glottic structures.…”
Section: Physiologic Responses To Intubationmentioning
confidence: 99%