Blutdruckanpassung und hormonelle Regulation bei Parkinson-Patienten nach Orthostase

Ak, Bellon; Wh, Jost; Schimrigk, К.; Konig, Justin; Zeppezauer, Michael

doi:10.1055/s-2008-1043109

Cited by 11 publications

(4 citation statements)

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“…Mean disease duration ranged from 1.9 to 11.3 years. In eight of the 25 studies the primary objective was to report on the prevalence of OH [10,11,20,23,28,30,32,34], while in the remaining 17 studies the proportion of patients with OH was investigated as a secondary objective. In 18 studies the study population consisted of tertiary care patients.…”

Section: Resultsmentioning

confidence: 99%

“…Only six of the studies in our review gave detailed information about the circumstances during the blood pressure measurements [10,22,25,31,38,39]. Furthermore, in seven studies patients with concurrent treatment for diabetes mellitus or hypertension were excluded [21,23,32,33,35,37,41]. Other important factors to consider are the role of age and disease duration.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of orthostatic hypotension in Parkinson’s disease: A systematic review and meta-analysis

Velseboer

Haan

Wieling

et al. 2011

Parkinsonism & Related Disorders

284

168

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Background Although orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson’s disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature. Methods From PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. Results We found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30.1% (95% CI: 22.9% to 38.4%). We found a large statistical heterogeneity between studies which could not be reduced by several subgroup analyses. Conclusions The estimated prevalence of OH in PD is 30%. However, due to the large heterogeneity between studies this pooled estimate should be interpreted with caution. More data from unselected population-based cohorts are needed.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence of orthostatic hypotension in Parkinson’s disease: A systematic review and meta-analysis

Velseboer

Haan

Wieling

et al. 2011

Parkinsonism & Related Disorders

284

168

View full text Add to dashboard Cite

show abstract

“…The most common autonomic disorder within the cardiovascular system in PD is orthostatic hypotension (OH), which in the literature is reported to affect 30–60 % of patients (Bellon et al 1996 ; Senarda et al 1997 ). The assumption that this disorder does not appear until the advanced stages of PD has been disproven in more recent studies (Jost and Augustis 2015 ).…”

Section: Symptoms Of Autonomic Dysfunctionmentioning

confidence: 99%

Parkinson’s disease between internal medicine and neurology

Csóti¹,

Jost

Reichmann³

2015

J Neural Transm

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General medical problems and complications have a major impact on the quality of life in all stages of Parkinson’s disease. To introduce an effective treatment, a comprehensive analysis of the various clinical symptoms must be undertaken. One must distinguish between (1) diseases which arise independently of Parkinson’s disease, and (2) diseases which are a direct or indirect consequence of Parkinson’s disease. Medical comorbidity may induce additional limitations to physical strength and coping strategies, and may thus restrict the efficacy of the physical therapy which is essential for treating hypokinetic-rigid symptoms. In selecting the appropriate medication for the treatment of any additional medical symptoms, which may arise, its limitations, contraindications and interactions with dopaminergic substances have to be taken into consideration. General medical symptoms and organ manifestations may also arise as a direct consequence of the autonomic dysfunction associated with Parkinson’s disease. As the disease progresses, additional non-parkinsonian symptoms can be of concern. Furthermore, the side effects of Parkinson medications may necessitate the involvement of other medical specialists. In this review, we will discuss the various general medical aspects of Parkinson’s disease.

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“…O rthostatic hypotension (OH) is the most frequent autonomic disturbance in patients with Parkinson's disease (PD), [1][2][3][4][5][6] with a prevalence as high as 20%. 7 Symptoms of orthostatic hypotension are caused by cerebral hypoperfusion, which results from an abnormal cerebrovascular response to changes in systemic blood pressure.…”

mentioning

confidence: 99%

Transcranial doppler ultrasonographic evaluation of cerebral circulation during passive tilting in patients with Parkinson's disease

Mihçi

Dora

Balkan

2007

J of Clinical Ultrasound

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Blutdruckanpassung und hormonelle Regulation bei Parkinson-Patienten nach Orthostase

Abstract: Abnormal orthostatic regulation occurs more frequently in PD than in healthy persons and is associated with changes in noradrenaline release. This suggests multisystem degeneration as a cause of PD.

Cited by 11 publications

References 0 publications

Prevalence of orthostatic hypotension in Parkinson’s disease: A systematic review and meta-analysis

Prevalence of orthostatic hypotension in Parkinson’s disease: A systematic review and meta-analysis

Parkinson’s disease between internal medicine and neurology

Transcranial doppler ultrasonographic evaluation of cerebral circulation during passive tilting in patients with Parkinson's disease

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