BMCP1, a Novel Mitochondrial Carrier with High Expression in the Central Nervous System of Humans and Rodents, and Respiration Uncoupling Activity in Recombinant Yeast

Sanchı́s, Daniel; Fleury, Christophe; Chomiki, Nathalie; Goubern, Marc; Huang, Quinling; Neverova, Maria; Gregoire, Francine M.; Easlick, Juliet; Raimbault, Serge; Lévi-Meyrueis, Corinne; Miroux, Bruno; Collins, Sheila; Seldin, Michael F.; Richard, Denis; Warden, Craig H; Bouillaud, Frédéric; Ricquier, Daniel

doi:10.1074/jbc.273.51.34611

Cited by 286 publications

(225 citation statements)

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“…In other respects, in the course of experiments on UCP1 expression in yeast carried out in collaboration with Eduardo Rial, a proton transport activity activated by ATP and inhibited by phosphate was described and named the yeast uncoupling pathway, or YUP [67]. A new homologue of mitochondrial carriers predominantly expressed in brain and referred to as BMCP1 (brain mitochondrial carrier protein 1) was also identified [16]. Curiously, although the sequence of this new protein is only moderately similar to the sequences of the UCPs (34-39 % identity), its expression in yeast induced a marked uncoupling of respiration and proton leak.…”

Section: Figure 1 Northern Analysis Of Ucp1 Ucp2 and Ucp3 Mrnas In Mmentioning

confidence: 99%

“…Other review papers on BAT mitochondria or UCPs have been published in recent years [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. Two other carriers predominantly expressed in brain and showing some uncoupling activity in recombinant systems were recently identified, and referred to as BMCP1 (brain mitochondrial carrier protein 1) [16] and UCP4 [17]. These two carriers are less similar to the UCPs, and will not be considered in this review.…”

Section: Introductionmentioning

confidence: 99%

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The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

Ricquier¹,

Bouillaud

2000

Biochemical Journal

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614

115

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Animal and plant uncoupling protein (UCP) homologues form a subfamily of mitochondrial carriers that are evolutionarily related and possibly derived from a proton\anion transporter ancestor. The brown adipose tissue (BAT) UCP1 has a marked and strongly regulated uncoupling activity, essential to the maintenance of body temperature in small mammals. UCP homologues identified in plants are induced in a cold environment and may be involved in resistance to chilling. The biochemical activities and biological functions of the recently identified mammalian UCP2 and UCP3 are not well known. However, recent data support a role for these UCPs in State 4 respiration, respiration uncoupling and proton leaks in mitochondria. Moreover, genetic studies suggest that UCP2 and UCP3 play a part in

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Section: Figure 1 Northern Analysis Of Ucp1 Ucp2 and Ucp3 Mrnas In Mmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

Ricquier¹,

Bouillaud

2000

Biochemical Journal

Self Cite

614

115

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“…The amino acid sequences of these two genes were calculated as having approximately 60% identity with Ucp1. Subsequently, expressed sequence tag analysis and hybridization screening identified two further UCP1 homologs that were exclusively expressed in the central nervous system; these were named UCP4 (17) and brain mitochondrial carrier protein-1 (BMCP1; also known as UCP5) (18). UCP2 shows the widest tissue expression of all UCPs (12,13).…”

Section: Uncoupling Proteinsmentioning

confidence: 99%

Nutritional and hormonal regulation of uncoupling protein 2

et al. 2009

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SummaryUncoupling proteins (UCPs) belong to a family of mitochondrial carrier proteins that are present in the mitochondrial inner membrane. Genetic and experimental studies have shown that UCP dysfunction can be involved in metabolic disorders and in obesity. Uncoupling protein-1 (UCP1; also known as thermogenin) was identified in 1988 and found to be highly expressed in brown adipose tissue. UCP1 allows the leak of protons in respiring mitochondria, dissipating the energy as heat; the enzyme has an important role in nonshivering heat production induced by cold exposure or food intake. In 1997, two homologs of UCP1 were identified and named UCP2 and UCP3. These novel proteins also lower mitochondrial membrane potential, but whether they can dissipate metabolic energy as heat as efficiently as UCP1 is open to dispute. Even after a decade of study, the physiological roles of these novel proteins have still not been completely elucidated. This review aims to shed light on the nutritional and hormonal regulation of UCP2 and on its physiological roles.

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“…(i) Artefactual uncoupling: The overexpression of these UCP1-homologues in cell culture systems [50][51][52] and/or in mouse skeletal muscle [53] was reported to …”

Section: Ucp1-homologues: Are They Mediators Of Thermogenesis?mentioning

confidence: 99%

Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance

Dulloo

Seydoux

Jacquet

2004

Physiology & Behavior

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After decades of controversies about the quantitative importance of autoregulatory adjustments in energy expenditure in weight regulation, there is now increasing recognition that even subtle variations in thermogenesis could, in dynamic systems and over the long term, be important in determining weight maintenance in some and obesity in others. The main challenge nowadays is to provide a mechanistic explanation for the role of adaptive thermogenesis in attenuating and correcting deviations of body weight and body composition, and in the identification of molecular mechanisms that constitute its effector systems. This workshop paper reconsiders what constitutes adaptive changes in thermogenesis and reassesses the role of the sympathetic nervous system (SNS) and uncoupling proteins (UCP1, UCP2, UCP3, UCP5/BMCP1) as the efferent and effector components of the classical one-control system for adaptive thermogenesis and fat oxidation. It then reviews the evidence suggesting that there are in fact two distinct control systems for adaptive thermogenesis, the biological significance of which is to satisfy-in a lifestyle of famine-and-feast-the needs to suppress thermogenesis for energy conservation during weight loss and weight recovery even under environmental stresses (e.g., cold, infection, nutrient imbalance) when sympathetic activation of thermogenesis has equally important survival value.Keywords: Obesity; Diabetes; Cachexia; Catecholamines; UCP Resistance to obesity in an obesigenic environmentOne of the greatest challenges towards understanding the aetiology of human obesity is to explain how in environments that promote overeating of high-fat foods and discourage physical activity, there is always a section of the population who, apparently without conscious effort, do not become obese. How do they resist obesity? How is constancy of body weight achieved over decades in these individuals? In addressing the issue of human susceptibility to leanness and fatness, there are three cardinal features of body weight regulation that need to be underlined: (i) Humans cannot escape the laws of thermodynamics.Whatever theory is put forward to explain body weight and body composition regulation, it is undeniable that changes in body energy stores (and ultimately body weight) cannot occur unless there is a difference between energy intake and energy expenditure. (ii) Subtle perturbations in energy balance can lead to obesity. To put it another way, long-term constancy of body weight can only be achieved if the matching between energy intake and energy expenditure is extremely precise, since an error of only 1% between input and output of energy, if persistent, will lead to a gain or loss of 1 kg per year or some 40 kg between the age of 20 to 60 years. Yet, a difference of 5% between energy intake and energy expenditure is hardly measurable with available techniques. (iii) Body weight is a fluctuating and oscillatory phenomenon. Even in individuals that maintain a relatively stable lean body weight over decades, the...

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BMCP1, a Novel Mitochondrial Carrier with High Expression in the Central Nervous System of Humans and Rodents, and Respiration Uncoupling Activity in Recombinant Yeast

Cited by 286 publications

References 21 publications

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

Nutritional and hormonal regulation of uncoupling protein 2

Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance

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