BMI at different childhood age periods associated with cardiometabolic disorders in young adulthood

Objective To explore the association between maternal thyroid peroxidase antibody (TPOAb) exposure and 5- to 6-year-old children's cardiometabolic risk (CMR). Methods A total of 2129 mother–child pairs were recruited from the Ma'anshan Birth Cohort (MABC) study. Serum TPOAb was retrospectively measured in pregnant women using an electrochemiluminescence immunoassay. CMR score was evaluated by the serum glycolipids, blood pressure, and waist circumference for children aged 5-6 years. Growth mixture modelling was used to fit trajectories of TPOAb levels throughout pregnancy. Multiple linear regression models and logistic regression models were used for statistical analyses. Results Two thousand one hundred twenty-nine mother–child pairs (mean [SD] age, 26.6 [3.6] years) were enrolled for the final study. Maternal TPOAb exposure in the first trimester increased children's overall CMR, glucose level, HOMA-IR, triglyceride level, boys’ overall CMR, boys’ glucose level, and girls’ glucose level. TPOAb exposure in the first trimester was also associated with lower boys’ high-density lipoprotein cholesterol (HDL-C) level. In the second trimester, maternal TPOAb exposure was positively associated with children's triglyceride level. Compared with low TPOAb trajectory, children with high maternal TPOAb trajectory had an increased risk of developing high CMR (OR = 3.40; 95% CI, 1.30-8.90), hyperglycemia (OR = 5.20; 95% CI, 2.20-12.28), insulin-resistance (adjusted OR = 2.12; 95% CI, 1.10-4.07), and hypertriglyceridemia (OR = 2.55; 95% CI, 1.06-6.14). Conclusions The first trimester of pregnancy is a critical period for maternal TPOAb exposure to affect CMR in children, with some sex specificity, mainly to the detriment of boys.

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Causal association between childhood obesity and risk of neuroblastoma: a Mendelian randomization study

Luo,

et al. 2023

Preprint

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Background: Childhood obesity increased risk for cancer in adulthood，but no existing comprehensive Mendelian randomization (MR) studies have focused on how childhood obesity affects pediatric tumors. This study aimed to perform a MR analysis to assess the causal association between childhood obesity and neuroblastoma risk using publicly available genome-wide association studies (GWAS) summary statistics. Methods: Childhood obesity data and neuroblastoma data are from the IEU open GWAS project, which were subjected to MR analyses. In this study, the inverse variance weighting (IVW) method was used as the predominant analysis method and was complemented by MR-Egger, simple mode, weighted median and weighted mode methods. The MR-PRESSO method was utilized to identify horizontal pleiotropy and potential outliers. Results: This study indicated that childhood obesity rises the possibility of neuroblastoma, which was significant in the IVW [OR (95%CI), 1.209 (1.016–1.439), P = 0.033], MR-Egger [OR (95%CI), 2.889 (1.178–7.084), P = 0.046] and weighted-median [OR (95%CI), 1.302(1.038–1.632), P = 0.022] analyses, but nonsignificant in the simple mode [OR (95%CI), 1.331 (0.927–1.909), P = 0.152] and weighted mode [OR (95%CI), 1.357 (1.000–1.840), P = 0.078] analyses. No significant heterogeneity or potential pleiotropy was detected, and the possibility of weak IVs was also excluded. Conclusion: This study revealed that childhood obesity increases the risk of neuroblastoma.

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BMI at different childhood age periods associated with cardiometabolic disorders in young adulthood

Cited by 3 publications

References 31 publications

Role of RIPK3 in lipid metabolism and postnatal overfeeding-induced metabolic disorders in mice

Role of RIPK3 in lipid metabolism and postnatal overfeeding-induced metabolic disorders in mice

Sex-specific effect of maternal thyroid peroxidase antibody exposure during pregnancy on 5- to 6-year-old children's cardiometabolic risk score: the Ma'anshan birth cohort study

Causal association between childhood obesity and risk of neuroblastoma: a Mendelian randomization study

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