BMP signaling and its paradoxical effects in tumorigenesis and dissemination

Zhang, Lijie; Ye, Yingnan; Long, Xin-Xin; Xiao, Pei; Ren, Xiubao; Yu, Jinpu

doi:10.18632/oncotarget.12151

Cited by 82 publications

(71 citation statements)

References 142 publications

(146 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To date, ~20 members of the BMP subgroup have been identified (13). Recently, more evidence demonstrated that BMPs participate in cancer development and progression, such as colon cancer (14). It has been reported that BMP-9 promoted a proliferative response and exerted a remarkable anti-apoptotic function in hepatocellular carcinoma (HCC)…”

Section: Introductionmentioning

confidence: 99%

Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells

et al. 2017

View full text Add to dashboard Cite

Abstract. Colon cancer is common worldwide and accounts for the significant cancer related morbidity and mortality in patients. Although extensive advancement has been made in colon cancer treatment and diagnosis in the last decades, there is still a giant gap between the clinical expectation. It has been reported that resveratrol (Res) may be a potential candidate for cancer treatment. However, the specific mechanism underlying this activity remains unclear. In this study, we investigated the anticancer activity of Res in human colon cancer cells, and unveiled the possible mechanism for this effect. With cell viability, flow cytometry, PCR and western blot analysis, we demonstrated the efficacious anticancer activity of Res in HCT116 cells. Mechanically, we found that Res greatly upregulates BMP7 in HCT116 cells. Exogenous BMP7 enhances the anticancer effect of Res in HCT116 cells, which was almost reversed by the BMP7 specific antibody. Res does not activate the BMPs/Smads signaling, but decreases the phosphorylation of Akt1/2/3 substantially in HCT116 cells. Exogenous BMP7 enhances the inhibitory effect of Res on the phosphorylation of Akt1/2/3, while BMP7 immunodepletion reverses this effect notably. Res markedly decreases the phosphorylation of PTEN, which can be enhanced by exogenous BMP7 but partly reversed by the BMP7 antibody. Our findings suggested that Res may be a promising candidate for colon cancer treatment, and the anticancer activity may be mediated by inactivating PI3K/Akt signaling through upregulating BMP7 to decrease, at least, the phosphorylation of

show abstract

Section: Introductionmentioning

confidence: 99%

Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells

et al. 2017

View full text Add to dashboard Cite

show abstract

“…An autogenous cancellous bone graft was used to augment healing in this high‐risk fracture. Bone grafts are osteoinductive, including stimulation of bone morphogenic proteins, which may play a role in tumorigenesis and regulation of cancer progression . The dog in this report also received pamidronate to limit bone resorption.…”

Section: Discussionmentioning

confidence: 92%

Pathologic fracture healing after femoral limb salvage in a dog

et al. 2019

View full text Add to dashboard Cite

Background Bone sarcomas are a significant cause of pain, disability, and mortality in dogs. A variety of surgical limb salvage options are available to preserve limb function with comparable prognosis to amputation. Case Report This report describes successful healing after plate fixation of an undifferentiated sarcoma pathologic femoral fracture in a dog. The fracture was treated surgically with curettage of the tumour site, placement of autogenous bone graft, and then stabilized using a locking plate rod construct. The patient regained excellent mobility after surgery and was managed with monthly pamidronate therapy. Serial radiographs demonstrate progressive healing of the pathologic fracture. Ultimately, the patient developed a maxillary fibrosarcoma and was euthanased 1 year after treatment of the femoral fracture. Postmortem histopathological evaluation of the pathologic fracture site demonstrated complete bone healing. Conclusion This case highlights the possibilities of limb salvage by fracture stabilization and bone healing as a viable option in select patients.

show abstract

“…Molecular and functional analyses of sprouting angiogenesis have uncovered a link between neuronal guidance and tip cell sprouting . Similarly, anti‐ and proangiogenic functions have been ascribed to various proteins involved in bone homeostasis . Emerging avenues further include the diverse functions elicited by microRNAs and the role of EC metabolism in angiogenesis .…”

Section: Resultsmentioning

confidence: 99%

“…BMPs belong to the TGF superfamily and consist of about 20 proteins that regulate multiple biological processes in development and morphogenesis . BMPs are synthesized in the cytoplasm as dimeric precursor proprotein complexes, which are cleaved by serine endoproteases before secretion …”

Section: Novel Angiogenic Regulators and Conceptsmentioning

confidence: 99%

“…Since then, the knowledge about (pathological) angiogenesis has increased tremendously: novel insights into tumor vascularization have revealed additional ways to increase intratumoral blood flow . Several new classes of angiogenesis regulators, including proteins involved in axon guidance and bone formation and microRNAs, were found to regulate various aspects of EC biology. EC metabolism, which only recently received attention, has been put forward as the key determinant of angiogenesis regulation .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation