BNCT of skin tumors using the high-energy D-T neutrons

Masoudi, S. Farhad; Rasouli, Fatemeh; Ghasemi, Marjan

doi:10.1016/j.apradiso.2017.01.010

Cited by 12 publications

(3 citation statements)

References 23 publications

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“…Boron Neutron Capture Therapy (BNCT) is a method for cancer therapy that combines irradiations using thermal neutron with that using 10 B isotope in a tumor. 10 B is highly probable to capture neutrons within the range of thermal energy (< 0.1 eV) and transforms into 11 B. Due to its instability, 11 B immediately disintegrates, emitting alpha particle and 7 Li.…”

Section: Introductionmentioning

confidence: 99%

“…10 B is highly probable to capture neutrons within the range of thermal energy (< 0.1 eV) and transforms into 11 B. Due to its instability, 11 B immediately disintegrates, emitting alpha particle and 7 Li. Li ion emits prompt gamma radiation, which is parasitic in BNCT as irradiates the normal tissue, cancer cell killing is mostly due to ions.…”

Section: Introductionmentioning

confidence: 99%

“…Such materials as plumbum and bismuth can be combined to make good collimator, owing to the characteristic of plumbum that reflect neutrons and Bi that absorbs gammas [10]. Other materials with neutron reflecting and gamma absorbing quality are lead and nickel and lead with BeO and graphite [9,11].…”

Section: Introductionmentioning

confidence: 99%

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Optimization and analysis of neutron distribution on 30 MeV cyclotron-based double layer beam shaping assembly (DLBSA)

Bilalodin¹,

Suparta²,

Hermanto³

et al. 2019

Nucl. Phys. At. Energy

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Design and optimization of double layer Beam Shaping Assembly (DLBSA) has been conducted using the MCNPX code. The BSA is configured to comply with such a construction having typically a double moderator, a reflector, a collimator, and a filter. The optimization of various combinations of materials that compose the moderator, reflector, and filter yields such quality and intensity of radiation beams that conform to the requirements for Boron Neutron Capture Therapy. The composing materials are aluminum and BiF 3 for moderator, lead and graphite for the reflector, nickel and polyethylene borate for the collimator, and iron and cadmium for the filter. Typical beam parameters measured at the exit of the collimator are epithermal neutron flux of 1.110 9 n/(cm 2 s), the ratio of epithermal neutron flux to thermal neutron and fast neutron flux 344 and 85, respectively, and the values of fast neutron and gamma dose to epithermal neutron flux 1.0910-13 Gycm 2 and 1.8210-13 Gycm 2 , respectively. Analysis of epithermal neutron flux and neutron beam spectrum using the PHITS code reveals that the distribution of epithermal neutron spreads out in the DLBSA. The highest intensity is found in the moderator and decline downstream of the collimator and filter. The spectrum of neutron beams displays a narrow spike with that peaks at 10 keV.

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