BNP as a Major Player in the Heart-Kidney Connection

Okamoto, Ryuji; Ali, Yusuf; Hashizume, Ryotaro; Suzuki, Noboru; M, Ito

doi:10.3390/ijms20143581

Cited by 69 publications

(47 citation statements)

References 133 publications

(157 reference statements)

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“…Natriuretic peptides are peptide hormones mostly released by the heart muscles in response to increased volume status and wall stress, which are key elements in cardiovascular physiology [1]. Brain natriuretic peptide (BNP) is a commonly measured natriuretic peptide, which is released in conditions that leads to volume expansion and increased myocardial wall pressure.…”

Section: Introductionmentioning

confidence: 99%

The Role of Brain Natriuretic Peptide as a Prognostic Marker for Sepsis

Bhandari

Cunningham

2020

Cureus

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Brain natriuretic peptide (BNP) is a neurohormone released in response to volume expansion and increased pressure. It is commonly used to assist in the diagnosis and management of heart failure. BNP can also play an important role as a biomarker in septic shock; however, elevations of BNP in conditions other than sepsis or cardiac dysfunction limits its use as the sole prognostic marker in patients hospitalized with sepsis. Further relationships regarding laboratory value and correlation with severity of illness need to be established with larger prospective studies to develop consensus regarding a cutoff point for optimum sensitivity and specificity in predicting in-hospital mortality related to sepsis.

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Section: Introductionmentioning

confidence: 99%

The Role of Brain Natriuretic Peptide as a Prognostic Marker for Sepsis

Bhandari

Cunningham

2020

Cureus

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“…Аргументация полученных данных может быть обеспечена тем, что в почках BNP увеличивает СКФ, расслабляя мезангиальные клетки, и ингибирует фракционную реабсорбцию натрия в канальцах, тем самым усиливая натрийурез и снижая АД, а также уменьшает сосудистое сопротивление, расслабляя гладкомышечные клетки артерий. Поэтому многие исследователи отмечают, что более низкие "исходные" концентрации BNP и NT-proBNP у пациентов с ГБ были связаны с более высоким риском развития как ХСН, так и поражения органов-мишеней [10,11]. Тем не менее, не вызывает сомнения и тот факт, что в патогенезе поражения органов-мишеней большую роль играют и другие системы: ренин-ангиотензин-альдостероновая система (РААС) и симпато-адреналовая система (СНС).…”

Section: материал и методыunclassified

“…Тем не менее, не вызывает сомнения и тот факт, что в патогенезе поражения органов-мишеней большую роль играют и другие системы: ренин-ангиотензин-альдостероновая система (РААС) и симпато-адреналовая система (СНС). Но BNP действует как компенсирующий агент только на ранних стадиях заболевания, уменьшая активность этих систем [10]. При прогрессировании заболевания, увеличивается активация РААС и СНС, происходит дисбаланс системы BNP, и несмотря на высокие уровни, эндогенный BNP становится резистентным и больше не способен компенсировать состояние в таких случаях.…”

Section: материал и методыunclassified

“…Полученные данные также можно объяснить тем фактом, что при нарушении компенсаторного действия BNP на почечную функцию, он становится резистентным и все его положительные эффекты устраняются. Но учитывая данные о том, что BNP локализуется в дистальных канальцах почек [10], можно предположить, что повышение уровня BNP и NT-proBNP будет отражать именно нарушение работы канальцев.…”

Section: материал и методыunclassified

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Assessment of glomerular and tubulointerstitial apparatus state depending on the level of the natriuretic peptide in hypertension patients

Чернявина

2020

Russ J Cardiol

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Aim. To assess the state of the glomerular and tubulointerstitial apparatus depending on the level of the N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with hypertension (HTN).Material and methods. The study included 119 patients with stage I-II HTN (target organ damage classification). We determined the cystatin C level, glomerular filtration rate (GFF) using the CKD-EPI equation, neutrophil gelatinase‐associated lipocalin (NGAL) and NT-proBNP levels; echocardiography and sphygmoplethysmography was performed. In the first analysis, patients were divided into two groups depending on the NT-proBNP level. Group 1 (n=32) consisted of patients with NTproBNP level >125 pg/ml, group 2 (n=87) — with NT-proBNP level <125 pg/ml. Empirically, the NT-proBNP cutoff point (75 pg/ml) was found to assess the role of cystatin C. The first group included 41 patients with NT-proBNP level >75 pg/ml, the second group — 78 patients with NT-proBNP level <75 pg/ml.Results. In the group 1 (NT-proBNP >125 pg/ml) the NGAL concentration was significantly higher than in the group 2: 2,50 [1,90;2,85] vs 1,30 [0,9;2,0] ng/ml, respectively (p=0,022). Patients in the groups did not significantly differ in the cystatin C levels and GFR (p=0,099 and p=0,090, respectively). When dividing patients according to the NT-proBNP cutoff point (75 pg/ml), the following data were obtained. The concentration of cystatin C in the first group with NT-proBNP >75 pg/ml was 1041,50 [995,00;1185,00] vs 964,30 [801,00;1090,00] ng/ml in the second group (p=0,034). Patients in the groups significantly differed in GFR (p=0,027). A correlation analysis revealed a moderate, direct relationship of NT-proBNP with cystatin C (r=0,32; p<0,005) and NGAL levels (r=0,36; p<0,05), as well as a moderate, inverse relationship with GFR (r=-0,35; p<0,005).Conclusion. NT-proBNP determination can be used as an integrative risk stratification tool for glomerular and tubulointerstitial injury in HTN patients.

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“…Известно также, что NT-proBNP является не только диагностическим критерием ХСН и маркером ее тяжести, но и ассоциируется с субклинической дисфункцией левого желудочка (ЛЖ) у бессимптомных лиц [3] и рассматривается как самостоятельный прогностический предиктор [4].…”

Section: For Citationunclassified

The risk of developing chronic heart failure in patients with hypertension depending on the actual arterial stiffness

Чернявина

Козиолова

2020

SMJ

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Objective. To determine the risk of developing chronic heart failure (CHF) in patients with hypertension (HTN) depending on the actual arterial stiffness.Material and Methods. The study included 175 patients with HTN without a verified diagnosis of heart failure. The average age was 48.5 ± 6.8 years. Patients underwent general clinical examination, volume sphygmoplethysmography assessments of cardio-ankle vascular index (CAVI), echocardiography study (left ventricular (LV) ejection fraction, LV diastolic function, LV myocardial mass index, indexed LV volume by echocardiography), and tests for serum N-terminal pro-B-type natriuretic peptide (NT-proBNP). Patients were divided into two groups depending on CAVI. Group 1 included 141 (80.6%) patients with CAVI < 9; group 2 included 34 (19.4%) patients with CAVI > 9.Results. In patients of group 1, the level of NT-proBNP was 0.008 [0.006; 5.770], which was significantly lower than the corresponding value in group 2, where the level of NT-proBNP was 13.08 [0.01; 350.65] ng/mL (p = 0.041). Indicators of odds ratio (OR) and relative risk (RR) were also significant. The chance of developing CHF with CAVI > 9 increased by almost 7 times (OR = 6.9; 95% CI = 2.8–16.8), and OR of CHF onset was 4.1 (95% CI = 2.2–7.6). Sensitivity and specificity rates were 55.9% and 84.4%, respectively. Correlation analysis revealed a medium degree of dependence and direct relationships between NT-proBNP level and CAVI values (r = 0.35; p <0.05).Conclusion. Serum level of NT-proBNP depended on the actual arterial stiffness. Patients with CAVI > 9 indicative of an increase in true arterial stiffness had a greater risk of developing heart failure assessed based on the level of NT-proBNP in the blood. Further studies are required to assess the effects of arterial stiffness, registered within the intermediate values of CAVI index, on the risk of heart failure onset.

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BNP as a Major Player in the Heart-Kidney Connection

Cited by 69 publications

References 133 publications

The Role of Brain Natriuretic Peptide as a Prognostic Marker for Sepsis

The Role of Brain Natriuretic Peptide as a Prognostic Marker for Sepsis

Assessment of glomerular and tubulointerstitial apparatus state depending on the level of the natriuretic peptide in hypertension patients

The risk of developing chronic heart failure in patients with hypertension depending on the actual arterial stiffness

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