BNT162b2-elicited neutralization of B.1.617 and other SARS-CoV-2 variants

Liu, Jianying; Liu, Yang; Xia, Hongjie; Zou, Jing; Weaver, Scott C.; Swanson, Kena A.; Cai, Hui; Cutler, Mark; Cooper, David A.; Muik, Alexander; Jansen, Kathrin U.; Şahin, Uğur; Xie, Xuping; Dormitzer, Philip R.; Shi, Pei Yong

doi:10.1038/s41586-021-03693-y

Cited by 339 publications

(280 citation statements)

References 29 publications

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“…A recent multicenter prospective cohort study in England found vaccine effectiveness upwards of 85% (19). Our results support high levels of protection afforded by vaccination, particularly among recipients of both doses (9,15,(20)(21)(22)(23)(24). The majority of cases in our study were among partially vaccinated individuals, emphasizing the importance of personal protective measures, and susceptibility to infection particularly until fully vaccinated (19,(24)(25)(26)(27).…”

supporting

confidence: 76%

“…The reports of mutants, known as Variants of Concerns (VOCs) that exhibit increased transmission or immune evasion, or both, have been reported in different global regions and predominant lineages have been genotyped (5). Of note, three VOCs, B.1.1.7 (recently named Alpha) (6), B.1.351 (Beta) (7), and P.1 (Gamma) (8) containing prominent mutations in the spike protein, emerged in the UK, South Africa and Brazil, respectively, and more recently, B.1.617.2 (Delta) (9) emerged in India and has spread globally. The mapping of specific mutations in the spike protein has revealed strong evidence of convergent evolution, and particularly the E484K polymorphism, which is able to evade certain monoclonal therapy and it is less responsive to neutralizing antibodies from recovered patients.…”

Section: Introductionmentioning

confidence: 99%

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Post-vaccination SARS-COV-2 among healthcare workers in New Jersey: a genomic epidemiological study

Mathema

Liang

Chow

et al. 2021

Preprint

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Emergence of SARS-CoV-2 with high transmission and immune evasion potential, the so-called Variants of Concern (VOC), is a major concern. We describe the early genomic epidemiology of SARS-CoV-2 recovered from vaccinated healthcare professionals (HCP). Our post-vaccination COVID-19 symptoms-based surveillance program among HCPs in a 17-hospital network, identified all vaccinated HCP who tested positive for COVID-19 after routine screening or after self-reporting. From 01/01/2021 to 04/30/2021, 23,687 HCP received either mRNA-1273 or BNT162b2 mRNA vaccine. All available post-vaccination SARS-CoV-2 samples and a random collection from non-vaccinated patients during the similar timeframe were subjected to VOC screening and whole genome sequencing (WGS). 62% (23,697/37,500) of HCPs received at least one vaccine dose, with 95% (22,458) fully vaccinated. We detected 138 (0.58%, 138/23,697) COVID-19 cases, 105 among partially vaccinated and 33 (0.15%, 33/22,458) among fully vaccinated. Five partially vaccinated required hospitalization, four with supplemental oxygen. VOC screening from 16 fully vaccinated HCPs identified 6 (38%) harboring N501Y and 1 (6%) with E484K polymorphisms; concurrent non-vaccinated samples was 37% (523/1404) and 20% (284/1394), respectively. There was an upward trend from January to April for E484K/Q (3% to 26%) and N501Y (1% to 49%). WGS analysis from vaccinated and non-vaccinated individuals indicated highly congruent phylogenies. We did not detect an increased frequency of any RBD/NTD polymorphism between groups (P>0.05). Our results support robust protection by vaccination, particularly among recipients of both doses. Despite VOCs accounting for over 40% of SARS-CoV-2 from fully vaccinated individuals, the genomic diversity appears to proportionally represent those among non-vaccinated populations.

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supporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Post-vaccination SARS-COV-2 among healthcare workers in New Jersey: a genomic epidemiological study

Mathema

Liang

Chow

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…The increased transmissibility and/or pathogenicity of the variants is due, at least in part, to mutations in the spike protein RBD that increase its affinity for ACE2 on target cells. Mutations in the Beta, Gamma and Delta variant spike RBDs have been shown to cause partial resistance to neutralization by the serum antibodies of vaccinated and convalescent individuals and therapeutic monoclonal antibodies [4][5][6][7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants

Tada

Zhou

Samanovic

et al. 2021

Preprint

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The increasing prevalence of SARS-CoV-2 variants has raised concerns regarding possible decreases in vaccine efficacy. Here, neutralizing antibody titers elicited by mRNA-based and an adenoviral vector-based vaccine against variant pseudotyped viruses were compared. BNT162b2 and mRNA-1273-elicited antibodies showed modest neutralization resistance against Beta, Delta, Delta plus and Lambda variants whereas Ad26.COV2.S-elicited antibodies from a significant fraction of vaccinated individuals were of low neutralizing titer (IC50 <50). The data underscore the importance of surveillance for breakthrough infections that result in severe COVID-19 and suggest the benefit of a second immunization following Ad26.COV2.S to increase protection against the variants.

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“…Little is known about its sensitivity to the humoral immune response. Recent reports indicated a reduced sensitivity of members of the B.1.617 lineage to certain monoclonal and polyclonal antibodies [1][2][3][4][5][7][8][9] .…”

mentioning

confidence: 99%

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Planas

Veyer

Baidaliuk

et al. 2021

Nature

1,966

124

1,811

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This is a PDF file of a peer-reviewed paper that has been accepted for publication. Although unedited, the content has been subjected to preliminary formatting. Nature is providing this early version of the typeset paper as a service to our authors and readers. The text and figures will undergo copyediting and a proof review before the paper is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.

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BNT162b2-elicited neutralization of B.1.617 and other SARS-CoV-2 variants

Cited by 339 publications

References 29 publications

Post-vaccination SARS-COV-2 among healthcare workers in New Jersey: a genomic epidemiological study

Post-vaccination SARS-COV-2 among healthcare workers in New Jersey: a genomic epidemiological study

Comparison of Neutralizing Antibody Titers Elicited by mRNA and Adenoviral Vector Vaccine against SARS-CoV-2 Variants

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

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