2023
DOI: 10.1111/rda.14412
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Boar sperm motility is modulated by CCK at a low concentration of bicarbonate under capacitation conditions

C. Moros‐Nicolás,
R. López‐Úbeda,
C. Luongo
et al.

Abstract: In a previous study, our group detected the cholecystokinin (CCK) protein in the porcine oviduct. This fact, together with the involvement of CCK in the regulation of sperm protein tyrosine phosphorylation by the modulation of HCO3− uptake (in mice and humans) suggests a role for CCK during sperm capacitation. Therefore, on the one hand, the expression of CCK receptors (CCK1R and CCK2R) on boar testes has been investigated and probed; on the other hand, boar spermatozoa (from seminal doses of 1‐day and 5‐day s… Show more

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“…The CCK type 1 receptor has been found in boar sperm, where incubation with CCK, in the presence of bicarbonate, has been shown to positively influence sperm motility and capacitation 144 , likely through the adenylyl cyclase/cAMP/protein kinase A signaling pathway 145 . Therefore, altered levels of CCK, such as those found in obese patients may negatively affect sperm function.…”
Section: Influence Of Gut Hormones On Sertoli and Germ Cell Physiologymentioning
confidence: 99%
“…The CCK type 1 receptor has been found in boar sperm, where incubation with CCK, in the presence of bicarbonate, has been shown to positively influence sperm motility and capacitation 144 , likely through the adenylyl cyclase/cAMP/protein kinase A signaling pathway 145 . Therefore, altered levels of CCK, such as those found in obese patients may negatively affect sperm function.…”
Section: Influence Of Gut Hormones On Sertoli and Germ Cell Physiologymentioning
confidence: 99%