Bodily pain in survivors of acute respiratory distress syndrome: A 1-year longitudinal follow-up study

Musculoskeletal complications following critical illness: A scoping review

“…Table 1 summarises the characteristics of the studies which included 31 observational and 1 interventional. There were 11 studies which were part of larger longitudinal or interventional studies [ [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] ], and 13 multicentre studies [ 7 , 21 , 23 , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] ]. The majority of studies included general ICU patients, however some studies investigated specific ICU patient populations including: Acute Respiratory Distress Syndrome (ARDS) [ 7 , 23 , 28 , 34 , 35 ], sepsis [ 21 , 36 ], blunt chest trauma [ 37 ] and severe acute respiratory syndrome (SARS) [ 25 ].…”

“…There were 11 studies which were part of larger longitudinal or interventional studies [ [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] ], and 13 multicentre studies [ 7 , 21 , 23 , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] ]. The majority of studies included general ICU patients, however some studies investigated specific ICU patient populations including: Acute Respiratory Distress Syndrome (ARDS) [ 7 , 23 , 28 , 34 , 35 ], sepsis [ 21 , 36 ], blunt chest trauma [ 37 ] and severe acute respiratory syndrome (SARS) [ 25 ]. Almost all studies were published after 2010 ( n = 29), and there was wide variation in both the duration of follow-up (Median 12 months, IQR 6–30) and the sample size (Median 87, IQR 50–167).…”

“…The majority of the studies ( n = 25) evaluated an aspect of muscle impairment [ 7 , 22 , 27 , 29 , 31 , 32 , [34] , [35] , [36] , [38] , [39] , [40] ] or chronic pain [ 26 , 28 , 37 , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] ]. There was also evaluation of neuromuscular function [ 21 , 23 , 30 , 50 ], peripheral joint impairment [ 33 , 51 ], fracture risk [ 24 ] and femoral head necrosis [ 25 ].…”

“…Several studies investigated risk factors for the development of MSK complications [ 21 , 28 , 37 , 41 , 42 , 45 , 47 , 49 , 51 ]. Only pre-admission co-morbidity and severity of illness were reported as independently associated with weakness [ 35 ].…”

“…Only pre-admission co-morbidity and severity of illness were reported as independently associated with weakness [ 35 ]. In contrast, age, sepsis, smoking history, in-ICU opioid use, duration of ventilation, hospital length of stay, female gender and days in ICU with hyperinflammation were all reported as associated with chronic pain [ 28 , 41 , 42 ]. However, there was disagreement between studies with several reporting no risk factors for the development of chronic pain [ 37 , 45 , 47 , 49 ].…”