Body adipose distribution among patients with type 2 diabetes mellitus

Xie, Liangjun; Cheng, Mu-Hua

doi:10.1016/j.orcp.2012.09.003

Cited by 5 publications

(2 citation statements)

References 93 publications

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“…Besides the cardiovascular complications, in type 2 diabetic patients, abnormal body adipose distribution is usually present, especially the visceral fat. The previous study showed that the patients of T2DM had more visceral fat compared with the healthy controls [27]. There are several mechanisms involved in the body adipose redistribution in type 2 diabetic patients.…”

Section: Discussionmentioning

confidence: 94%

Evaluation of Epicardial Adipose Tissue in Patients of Type 2 Diabetes Mellitus by Echocardiography and its Correlation with Intimal Medial Thickness of Carotid Artery

Wang

Zhang

Liu

et al. 2017

Exp Clin Endocrinol Diabetes

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The present study aimed to evaluate the diagnostic value of echocardiography in measuring the thickness of epicardial adipose tissue (EAT) of the patients of type 2 diabetes mellitus (T2DM) and its correlation with the intimal-medial thickness of the carotid artery (cIMT) to investigate the relationship between EAT and cIMT. 68 patients of T2DM were enrolled and were divided into 2 groups: group of T2DM with duration≤10 years (35 cases) and group of T2DM with duration>10 years (33 cases). And 30 healthy subjects were enrolled as the control group. The thickness of EAT and cIMT were measured by echocardiography and high-frequency ultrasonography. The thickness of EAT and IMT of the carotid artery of 2 type 2 diabetic groups (duration≤10 years and>10 years) were significantly higher than that of the control group (all p<0.05), and the thickness of EAT and cIMT of the group of T2DM with duration>10 years were significantly higher than that of the group of T2DM with duration≤10 years (p<0.05). In univariate analysis, the thickness of EAT was positively and significantly associated with age (r0412, p005), BMI r0566, p005), waist circumference (r075, p005), LDL (r0425, p005), TG (r0496, p005), duration of diabetes (r=0.384, p<0.05 and cIMT (r0456, p005). In multiple stepwise regression analyses, age, BMI and IMT of carotid artery were appeared to be significantly associated with EAT (p<0.05 for all). In conclusion, routine screening of EAT and cIMT by ultrasonography in type 2 diabetic patients helps us to predict cardiovascular risks and prevent further development of cardiovascular complications.

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Section: Discussionmentioning

confidence: 94%

Evaluation of Epicardial Adipose Tissue in Patients of Type 2 Diabetes Mellitus by Echocardiography and its Correlation with Intimal Medial Thickness of Carotid Artery

Wang

Zhang

Liu

et al. 2017

Exp Clin Endocrinol Diabetes

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“…Tregs comprise various T-cell subsets with inhibitory properties, and have been shown to express phenotypic markers including interleukin (IL)-2-receptor alpha chains, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), glucocorticoid-induced tumor necrosis factor receptor (GITR), forkhead box protein 3 (Foxp3), and lymphocyte activation gene 3 (LAG3) (10). CTLA-4 belongs to the immunoglobulin-related family of receptors that mediate various aspects of T-cell immune regulation (11).…”

Section: Introductionmentioning

confidence: 99%

Effect of Cytotoxic T-Lymphocyte Antigen-4 on the Efficacy of the Fatty Acid-Binding Protein Vaccine Against Schistosoma japonicum

et al. 2019

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The present study evaluated the impact of blocking cytotoxic T-lymphocyte antigen-4 (CTLA-4) activity on the protective effect elicited by the fatty acid binding protein (FABP) vaccine against Schistosoma japonicum infection. Mice were randomly divided into uninfected, infected control, anti-CTLA-4 monoclonal antibody (anti-CTLA-4 mAb), FABP, and combination (anti-CTLA-4 mAb and FABP) groups. An assessment of the S. japonicum worm and egg burden in the infected mice revealed that the worm reduction-rate induced by FABP administration was increased from 26.58 to 54.61% by co-administration of the monoclonal anti-CTLA antibody (anti-CTLA-4 mAb). Furthermore, the regulatory T cell (Treg) percentage was significantly increased in mice after administration of the anti-CTLA-4 mAb, but not the FABP vaccine, and elevated levels of the cytokines interferon (IFN)-γ, interleukin (IL)-2, IL-4, and IL-5 were observed in infected mice that were administered the anti-CTLA-4 mAb. Notably, the diameter of egg granulomas in the anti-CTLA-4 mAb and combination groups was significantly increased compared to that observed in the infected control group. Together, these results suggest that co-administering the FABP vaccine and anti-CTLA-4 treatment may have synergistically increased the immunoprotective effect of the FABP vaccine by promoting T-helper 1-type immune responses, while incurring increased tissue damage.

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Automatic user sentiments extraction from diabetes mobile apps – An evaluation of reviews with machine learning

Ossai

Wickramasinghe

2022

Informatics for Health and Social Care

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Body adipose distribution among patients with type 2 diabetes mellitus

Cited by 5 publications

References 93 publications

Evaluation of Epicardial Adipose Tissue in Patients of Type 2 Diabetes Mellitus by Echocardiography and its Correlation with Intimal Medial Thickness of Carotid Artery

Evaluation of Epicardial Adipose Tissue in Patients of Type 2 Diabetes Mellitus by Echocardiography and its Correlation with Intimal Medial Thickness of Carotid Artery

Effect of Cytotoxic T-Lymphocyte Antigen-4 on the Efficacy of the Fatty Acid-Binding Protein Vaccine Against Schistosoma japonicum

Automatic user sentiments extraction from diabetes mobile apps – An evaluation of reviews with machine learning

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