Body, ambient and felt temperature: An attempt to resolve a human and mice dilemma

Marignac, Geneviève; Pilot-Storck, Fanny

doi:10.1016/j.biochi.2023.05.005

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…To overcome this situation, some strategies can be used, such as maintaining an average temperature that does not affect animals or humans so much, associated with this, offering environmental enrichments that contribute to thermal insulation, such as materials for nesting and shelters and, whenever as possible, keep the animals in groups, so that they warm each other ( 38 ). In cases where the animal’s thermoneutral temperature is lower than that of humans, environmental enrichment strategies with water, ice and ventilation may be useful.…”

Section: Important Environmental Factors In Experimentation With Rodentsmentioning

confidence: 99%

Impact of quality and transparency in scientific writing on the reduction of animal usage in experimental protocols: a review based in pertinent literature

Neves,

Klein,

Silva

et al. 2024

Front. Vet. Sci.

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The irreproducibility in scientific research has become a critical issue. Despite the essential role of rigorous methodology in constructing a scientific article, more than half of publications, on average, are considered non-reproducible. The implications of this irreproducibility extend to reliability problems, hindering progress in technological production and resulting in substantial financial losses. In the context of laboratory animal research, this work emphasizes the importance of choosing an appropriate experimental model within the 3R’s principle (Refine, Reduce, Replace). This study specifically addresses a deficiency in data specification in scientific articles, revealing inadequacies in the description of crucial details, such as environmental conditions, diet, and experimental procedures. For this purpose, 124 articles from journals with relevant impact factors were analyzed, conducting a survey of data considered important for the reproducibility of studies. Important flaws in the presentation of data were identified in most of the articles evaluated. The results of this study highlight the need to improve the description of essential information, standardizing studies, and ensuring the reproducibility of experiments in areas such as metabolism, immunity, hormones, stress, among others, to enhance the reliability and reproduction of experimental results, aligning with international guidelines such as ARRIVE and PREPARE.

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Section: Important Environmental Factors In Experimentation With Rodentsmentioning

confidence: 99%

Impact of quality and transparency in scientific writing on the reduction of animal usage in experimental protocols: a review based in pertinent literature

Neves,

Klein,

Silva

et al. 2024

Front. Vet. Sci.

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Bring the heat: Thermal stress, metabolic plasticity, and considerations for biomedical research

Motyl

MacDougald

2023

Biochimie

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A Review of the Effects of Some Extrinsic Factors on Mice Used in Research

Gozalo,

Elkins

2023

comp med

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Animals have been used in research for over 2,000 y. From very crude experiments conducted by ancient scholars, animal research, as a science, was refined over hundreds of years to what we know it as today. However, the housing conditions of animals used for research did not improve significantly until less than 100 years ago when guidelines for housing research animals were first published. In addition, it was not until relatively recently that some extrinsic factors were recognized as a research variable, even when animals were housed under recommended guidelines. For example, temperature, humidity, light, noise, vibration, diet, water, caging, bedding, etc., can all potentially affect research using mice, contributing the inability of others to reproduce published findings. Consequently, these external factors should be carefully considered in the design, planning, and execution of animal experiments. In addition, as recommended by others, the housing and husbandry conditions of the animals should be described in detail in publications resulting from animal research to improve study reproducibility. Here, we briefly review some common, and less common, external factors that affect research in one of the most popular animal models, the mouse.

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Body, ambient and felt temperature: An attempt to resolve a human and mice dilemma

Cited by 3 publications

References 19 publications

Impact of quality and transparency in scientific writing on the reduction of animal usage in experimental protocols: a review based in pertinent literature

Impact of quality and transparency in scientific writing on the reduction of animal usage in experimental protocols: a review based in pertinent literature

Bring the heat: Thermal stress, metabolic plasticity, and considerations for biomedical research

A Review of the Effects of Some Extrinsic Factors on Mice Used in Research

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