Body burden of organohalogenated pollutants and polycyclic aromatic hydrocarbons in Romanian population: Influence of age, gender, body mass index, and habitat

Luzardo, Octavio P.; Badea, Mihaela; Zumbado, Manuel; Rogozea, Liliana; Floroian, Laura; Ilea, Anca; Moga, Marius; Sechel, Gabriela; Boada, Luís D.; Henríquez-Hernández, Luis Alberto

doi:10.1016/j.scitotenv.2018.11.404

Cited by 34 publications

(19 citation statements)

References 35 publications

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“…One finding that apparently disagrees with this result was the higher concentrations of polybrominated diphenyl ethers (PBDEs) in Canadian children than in adults. The authors assumed that this experimental result was due to dermal contact and dust ingestion by children and, possibly, to placental transfer and breastfeeding [ 14 ]. This result was also reported by Schettgen et al [ 17 ] in German children, supporting the hypothesis that the cause is related to the breastfeeding of babies.…”

Section: Discussionmentioning

confidence: 99%

“…Among non-occupationally exposed subjects, PHE was the most frequently detected substance in blood, whereas NAP was the PAH detected with the highest serum concentration [ 14 , 54 ]. The dominant PAHs in human whole blood were low-molecular-weight PAHs (2–4 rings), whereas higher-molecular-weight PAHs were found at relatively lower concentrations [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

“…In general, blood is the preferred matrix for many chemicals, as it is in continuous contact with the whole organism and is in equilibrium with organs and tissues; it is used for the determination of POPs [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 38 , 39 , 41 , 42 , 54 , 55 , 56 , 58 , 59 , 62 , 63 , 64 , 65 , 66 , 67 , 69 , 70 , 71 , 72 ] with the exception of some POPs [ 39 , 40 , 44 ], PAHs [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 53 ], and some pesticides (i.e., pyrethroids) [ ...…”

Section: Discussionmentioning

confidence: 99%

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Human Biomonitoring of Environmental and Occupational Exposures by GC-MS and Gas Sensor Systems: A Systematic Review

Longo

Forleo

Giampetruzzi

et al. 2021

IJERPH

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Environmental chemicals and contaminants coming from multiple external sources enter the human body, determining a potential risk for human health. Human biomonitoring (HBM), measuring the concentrations of biomarkers in human specimens, has become an emerging approach for assessing population-wide exposure to hazardous chemicals and health risk through large-scale studies in many countries. However, systematic mapping of HBM studies, including their characteristics, targeted hazardous pollutants, analytical techniques, and sample population (general population and occupationally exposed workers), has not been done so far. We conducted a systematic review of the literature related to airborne hazardous pollutants in biofluids to answer the following questions: Which main chemicals have been included in the literature, which bodily fluids have been used, and what are the main findings? Following PRISMA protocol, we summarized the publications published up to 4 February 2021 of studies based on two methods: gas-chromatography/mass spectrometry (GC/MS) and electronic noses (e-noses). We screened 2606 records and 117 publications were included in the analysis, the most based on GC/MS analysis. The selected HBM studies include measurements of biomarkers in different bodily fluids, such as blood, urine, breast milk, and human semen as well as exhaled air. The papers cover numerous airborne hazardous pollutants that we grouped in chemical classes; a lot of hazardous and noxious compounds, mainly persistent organic pollutants (POPs) and volatile organic compounds (VOCs), have been detected in biological fluids at alarming levels. The scenario that emerged from this survey demonstrates the importance of HBM in human exposure to hazardous pollutants and the need to use it as valid tool in health surveillance. This systematic review represents a starting point for researchers who focus on the world of pollutant biomonitoring in the human body and gives them important insights into how to improve the methods based on GC/MS. Moreover, it makes a first overview of the use of gas sensor array and e-noses in HBM studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Human Biomonitoring of Environmental and Occupational Exposures by GC-MS and Gas Sensor Systems: A Systematic Review

Longo

Forleo

Giampetruzzi

et al. 2021

IJERPH

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“…Sample preparation, instrumentation, and quality assurance/quality control are extensively exposed in a previous publication [2,3]. We used PASW Statistics version 19.0 (SPSS Inc., Chicago, IL, USA) to manage the database and perform statistics [2].…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Database of persistent organic pollutants in umbilical cord blood: Concentration of organochlorine pesticides, PCBs, BDEs and polycyclic aromatic hydrocarbons

et al. 2020

Self Cite

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Persistent organic pollutants (POPs) have been banned over the last decades for being damaged to the environment and to the health of humans and animals. However, due to their lipophilic nature and resistance to degradation, they are frequently detected in biological samples. Its presence has been associated with the increased risk of suffering from different diseases in human series, being newborns and children especially sensitive. The present data reports umbilical cord blood levels of twenty organochlorine pesticides (aldrin, dieldrin, endrin, o,p'-DDD, p,p'-DDD, o,p'-DDE, p,p'-DDE, o,p'-DDT, p,p'-DDT, endosulfan alfa, endosulfan beta, endosulfan sulphate, heptachlor, HCB, αHCH, βHCH, δHCH, lindane, methoxychlor and mirex), eighteen polychlorinated biphenyls (congeners 28, 52, 77, 81, 101, 105, 114, 118, 123, 126, 138, 153, 156, 157, 167, 169, 180 and 189), eight bromodiphenyl ethers (congeners 28, 47, 85, 99, 100, 153, 154 and 183), and sixteen polycyclic aromatic hydrocarbons (acenaphthalene, acenaphthene, anthracene, benzo(a)anthracene, benzo(a)pyrene, benzo(b)fluoranthene, benzo(g,h,i)perylene, benzo(k)fluoranthene, chrysene, dibenzo(a,h)anthracene, fluoranthene, fluorine, indene(1,2,3-cd)pyrene, naphthalene, phenanthrene and pyrene). A total of 447 samples, representing 86.6% of the total births during the recruited period (March 1, 2015, to April 30, 2016), were available for POP analyses. POPs were determined in a Gas Chromatography (GC) system equipped with an automated sampler (Models 7890B and 7693; Agilent Technologies, Palo Alto, CA, USA) for gas chromatographic separations. The detection of the analytes was performed using a Triple Quad 7010 mass spectrometer (Agilent Technologies). All of the measurements were performed as triplicate measurements, and the means were used for the calculations. Data are reported in ng/mL. The present data also includes birth parameters, including weight, length, cranial perimeter, Apgar score and congenital malformations, and data referred to mothers (harmful habits, chronic diseases, and anthropometric/demographic characteristics).

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“…Because pesticides exposure typically occurs over long-lasting and involves nonlethal doses; moreover, pesticides might be metabolized efficiently in vivo, and therefore serum measurement techniques need to present very low detection limits. For example, Luzardo et al reported that exposure of infants and adults to organochloride pesticides, polychlorinated biphenyl, and persistent organic pollutants could result in serum levels as low as 0.148 µg/L [22,23]. However, few researchers have measured lower pesticides residue levels in human serum.…”

Section: Introductionmentioning

confidence: 99%

Salt‐assisted acetonitrile extraction and HPLC‐QTOF‐MS/MS detection for residues of multiple classes of pesticides in human serum samples

Yin

Fang

Zhang

et al. 2020

J of Separation Science

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Detecting pesticide residues in human serum is a challenging process. In this study we developed and validated a method for the extraction and recovery of residues of multiple classes of pesticides from serum using one reagent. Salt‐assisted acetonitrile extraction and high‐performance liquid chromatography with quadrupole time of flight tandem mass spectrometry were used to quantitate 34 pesticides classified in nine groups of chemicals in human serum samples, which are frequently detected in food. The recoveries for 33 of analyzed pesticides ranged from 86 to 112% with relative standard deviations below 15%. The limits of quantitation and linearity of 31 of the pesticides were 1 µg/L and >0.990, respectively. The lower limit of quantitation has been reported in the literature particularly for multi‐classes pesticide mixtures in human serum. The salt–acetonitrile reagent was allowed to achieve good recoveries and detection limits, which could be attributed to salt altering the solvent polarity, preferentially collecting the organic phase in the solution, and promoting the extraction. The developed method was applied for two organophosphate pesticide metabolites, diethylphosphate and 3,5,6‐trichloro‐2‐pyridinol, in serum from rats that were fed a nonlethal quantity of chlorpyrifos. The concentrations of these two were 252.18 ± 15.47 and 0.63 ± 0.23 µg/L, respectively.

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Body burden of organohalogenated pollutants and polycyclic aromatic hydrocarbons in Romanian population: Influence of age, gender, body mass index, and habitat

Cited by 34 publications

References 35 publications

Human Biomonitoring of Environmental and Occupational Exposures by GC-MS and Gas Sensor Systems: A Systematic Review

Human Biomonitoring of Environmental and Occupational Exposures by GC-MS and Gas Sensor Systems: A Systematic Review

Database of persistent organic pollutants in umbilical cord blood: Concentration of organochlorine pesticides, PCBs, BDEs and polycyclic aromatic hydrocarbons

Salt‐assisted acetonitrile extraction and HPLC‐QTOF‐MS/MS detection for residues of multiple classes of pesticides in human serum samples

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