Body composition and blood pressure in 6-year-old singletons born after pre-implantation genetic testing for monogenic and structural chromosomal aberrations: a matched cohort study

Belva, Florence; Roelants, Mathieu; Kluijfhout, Salome Adriana; Winter, C.; Schrijver, F. De; Desmyttere, Sonja; Rycke, Martine De; Tournaye, Herman; Liebaers, Inge; Bonduelle, M.

doi:10.1093/hropen/hoy013

Cited by 11 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…aged children born after IVF/ICSI and naturally conceived children from families with a genetic disorder. A study of 6-year-old children born after PGD showed no difference in BMI when compared with children born after ICSI (9). However, an earlier study of the same research group of 2year-old children born after PGD and PGS found that they had slightly lower BMIs than children born after NC (8).…”

Section: Discussionmentioning

confidence: 90%

“…Desmyttere et al (7,8) studied health and auxological data (outcome measures: weight, height, head, arm, and waist circumference) of 2-year-old children born after PGD or preimplantation genetic screening (PGS). Some of these children were also studied at the age of 6 and compared with children born after ICSI (9). Banerjee et al (10) reported on the health, height, and weight of 10 children born after PGD with a mean age of 18.4 months.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis

Heijligers

Peeters

Montfoort

et al. 2019

Fertility and Sterility

View full text Add to dashboard Cite

Objective: To evaluate the growth, health, and motor development of children born after preimplantation genetic diagnosis (PGD). Design: Observational cohort study and comparison of 5-year-old children born after PGD to similar aged children born after IVF/ intracytoplasmic sperm injection (ICSI) and children from families with a genetic disorder born after natural conception (NC). Setting: University hospital. Patient(s): One hundred three children were included in the PGD group. The two control groups consisted of 90 children born after IVF/ ICSI and 58 children born after NC. Intervention(s): PGD. Main Outcome Measure(s): We measured height, weight, body circumferences, body mass index, and blood pressure and performed a dysmorphological and neurological examination. We also collected data about the children's medical history, health care consultations, and motor milestones. Result(s): The mean height, weight, and body mass index were comparable for all groups. Six (5.8%) PGD, four (4.4%) IVF/ICSI, and five (8.6%) NC children had a major congenital abnormality. The incidence of acute and chronic illnesses was similar in all groups. Motor milestones were achieved on time, but the IVF/ICSI group had a slightly younger mean sitting age. None of the children had severe neurological problems. Conclusion(s): Five-year-old children born after PGD show normal growth, health, and motor development when compared with children born after IVF/ICSI and NC children from families with a genetic disorder.Trial registration number: NCT02149485. (Fertil Steril Ò 2019;111:1151-8. Ó2019 by American Society for Reproductive Medicine.) El resumen está disponible en Español al final del artículo.

show abstract

Section: Discussionmentioning

confidence: 90%

mentioning

confidence: 99%

Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis

Heijligers

Peeters

Montfoort

et al. 2019

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…There are no previous studies published investigating the early childhood outcome for PGT children concerning somatic and psychiatric diseases. The few earlier studies on growth, neurological development, body composition and blood pressure (Desmyttere et al, 2009, Belva et al, 2018, Kuiper et al, 2018 all suffer from small sample sizes and methodological problems such as unclear selection of controls, data reported by questionnaires to the parents and low participation rates.…”

Section: Commentsmentioning

confidence: 99%

Perinatal and maternal outcome after vitrification of blastocysts: a Nordic study in singletons from the CoNARTaS group

et al. 2019

View full text Add to dashboard Cite

STUDY QUESTION Is transfer of vitrified blastocysts associated with higher perinatal and maternal risks compared with slow-frozen cleavage stage embryos and fresh blastocysts? SUMMARY ANSWER Transfer of vitrified blastocysts is associated with a higher risk of preterm birth (PTB) when compared with slow-frozen cleavage stage embryos and with a higher risk of a large baby, hypertensive disorders in pregnancy (HDPs) and postpartum hemorrhage (PPH) but a lower risk of placenta previa when compared with fresh blastocysts. WHAT IS KNOWN ALREADY Transfer of frozen-thawed embryos (FETs) plays a central role in modern fertility treatment, limiting the risk of ovarian hyperstimulation syndrome and multiple pregnancies. Following FET, several studies report a lower risk of PTB, low birth weight (LBW) and small for gestational age (SGA) yet a higher risk of fetal macrosomia and large for gestational age (LGA) compared with fresh embryos. In recent years, the introduction of new freezing techniques has increased treatment success. The slow-freeze technique combined with cleavage stage transfer has been replaced by vitrification and blastocyst transfer. Only few studies have compared perinatal and maternal outcomes after vitrification and slow-freeze and mainly in cleavage stage embryos, with most studies indicating similar outcomes in the two groups. Studies on perinatal and maternal outcomes following vitrified blastocysts are limited. STUDY DESIGN, SIZE, DURATION This registry-based cohort study includes singletons born after frozen-thawed and fresh transfers following the introduction of vitrification in Sweden and Denmark, in 2002 and 2009, respectively. The study includes 3650 children born after transfer of vitrified blastocysts, 8123 children born after transfer of slow-frozen cleavage stage embryos and 4469 children born after transfer of fresh blastocysts during 2002–2015. Perinatal and maternal outcomes in singletons born after vitrified blastocyst transfer were compared with singletons born after slow-frozen cleavage stage transfer and singletons born after fresh blastocyst transfer. Main outcomes included PTB, LBW, macrosomia, HDP and placenta previa. PARTICIPANTS/MATERIALS, SETTING, METHODS Data were obtained from the CoNARTaS (Committee of Nordic ART and Safety) group. Based on national registries in Sweden, Finland, Denmark and Norway, the CoNARTaS cohort includes all children born after ART treatment in public and private clinics 1984–2015. Outcomes were assessed with logistic multivariable regression analysis, adjusting for the country and year of birth, maternal age, body mass index, parity, smoking, parental educational level, fertilisation method (IVF/ICSI), single embryo transfer, number of gestational sacs and the child’s sex. MAIN RESULTS AND THE ROLE OF CHANCE A higher risk of PTB (<37 weeks) was noted in the vitrified blastocyst group compared with the slow-frozen cleavage stage group (adjusted odds ratio, aOR [95% CI], 1.33 [1.09–1.62]). No significant differences were observed for LBW (<2500 g), SGA, macrosomia (≥4500 g) and LGA when comparing the vitrified blastocyst with the slow-frozen cleavage stage group. For maternal outcomes, no significant difference was seen in the risk of HDP, placenta previa, placental abruption and PPH in the vitrified blastocyst versus the slow frozen cleavage stage group, although the precision was limited. When comparing vitrified and fresh blastocysts, we found higher risks of macrosomia (≥4500 g) aOR 1.77 [1.35–2.31] and LGA aOR 1.48 [1.18–1.84]. Further, the risks of HDP aOR 1.47 [1.19–1.81] and PPH aOR 1.68 [1.39–2.03] were higher in singletons born after vitrified compared with fresh blastocyst transfer while the risks of SGA aOR 0.58 [0.44–0.78] and placenta previa aOR 0.35 [0.25–0.48] were lower. LIMITATIONS, REASONS FOR CAUTION Since vitrification was introduced simultaneously with blastocyst transfer in Sweden and Denmark, it was not possible to explore the effect of vitrification per se in this study. WIDER IMPLICATIONS OF THE FINDINGS The results from the change of strategy to vitrification of blastocysts are reassuring, indicating that the freezing technique per se has no major influence on the perinatal and maternal outcomes. The higher risk of PTB may be related to the extended embryo culture rather than vitrification. STUDY FUNDING/COMPETING INTEREST(S) The study is part of the ReproUnion Collaborative study, co-financed by the European Union, Interreg V ÖKS. The study was also financed by grants from the Swedish state under the agreement between the Swedish government and the county councils, the ALF agreement (LUA/ALF 70940), Hjalmar Svensson Research Foundation and NordForsk (project 71 450). There are no conflicts of interest to declare. TRIAL REGISTRATION NUMBER ISRCTN11780826.

show abstract

“…Developmental neurological and cognitive assessment and follow-up on psychomotor and social functioning showed that PGT pre-schoolers were comparable with controls born after ICSI or after spontaneous conception (Winter et al 2014, Sacks et al 2016, Heijligers et al 2019. Another study on body composition and blood pressure showed no adverse outcomes for 6-year-old children born after PGT (with day 3 embryo biopsy followed by blastocyst transfer) compared to children born after ICSI without embryo biopsy (Belva et al 2018). In summary, the follow-up results have so far been reassuring but further monitoring of the safety of PGT and the long-term health of the children remains necessary.…”

Section: Children Follow-upmentioning

confidence: 97%

PREIMPLANTATION GENETIC TESTING: Clinical experience of preimplantation genetic testing

et al. 2020

View full text Add to dashboard Cite

Thirty years of rapid technological advances in the field of genetic testing and assisted reproduction have reshaped the procedure of preimplantation genetic testing (PGT). The development of whole genome amplification and genome-wide testing tools together with the implementation of optimal hormonal stimulation protocols and more efficient cryopreservation methods have led to more accurate diagnoses and improved clinical outcomes. In addition, the shift towards embryo biopsy at day 5/6 has changed the timeline of a typical PGT clinical procedure. The Brussels' PGT centre started more than 25 years ago, offering PGT within a healthcare system funded by the government. In this paper, we have summarized our experience with PGT, presenting an up-to-date overview of the different steps in PGT from patient referral to baby follow-up.

show abstract

Body composition and blood pressure in 6-year-old singletons born after pre-implantation genetic testing for monogenic and structural chromosomal aberrations: a matched cohort study

Cited by 11 publications

References 27 publications

Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis

Growth, health, and motor development of 5-year-old children born after preimplantation genetic diagnosis

Perinatal and maternal outcome after vitrification of blastocysts: a Nordic study in singletons from the CoNARTaS group

PREIMPLANTATION GENETIC TESTING: Clinical experience of preimplantation genetic testing

Contact Info

Product

Resources

About