Body composition and body mass index in Duchenne muscular dystrophy: Role of dietary intake

Bernabe‐García, Mariela; Rodríguez‐Cruz, Maricela; Atilano, Salvador; Cruz-Guzmán, Oriana del Rocío; Almeida-Becerril, Tomas; Calder, Philip C.; J, González

doi:10.1002/mus.26340

Cited by 24 publications

(27 citation statements)

References 42 publications

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“…Due to weight gain, short stature, loss of muscle mass, and fat mass accumulation, body mass index (BMI) is not the best way to assess the nutritional status in DMD patients [8,9]. DMD boys had lower levels of body cell mass and hydration compared with the healthy population described in the literature.…”

Section: Introductionmentioning

confidence: 99%

Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy

et al. 2020

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The evaluation of fat-free mass (FFM) in patients with Duchenne muscular dystrophy (DMD) is useful to investigate disease progression and therapeutic efficacy. This study aimed to validate the Bioelectrical impedance (BIA) method compared with the dual-energy X-ray absorptiometry (DXA) for estimating the %FFM in boys with DMD. This is a cross-sectional study performed with children and adolescents diagnosed with DMD. Resistance and reactance were measured with a BIA analyzer, from which eight predictive equations estimated the %FFM. The %FFM was also determined by DXA and its used as a reference method. Pearson correlation test, coefficient of determination, the root-mean-square error, the interclass correlation coefficient, and linear regression analysis were performed between %FFM values obtained by BIA and DXA. The agreement between these values was verified with the Bland-Altman plot analysis. Forty-six boys aged from 5 to 20 years were enrolled in the study. All the equations showed a correlation between the %FFM estimated by BIA and determined by DXA (p < 0.05). The Bland-Altman method indicated that two equations have a significant bias (p < 0.05) and six equations showed no significant bias of %FFM (p > 0.05). However, one of them has high variation and wide limits of agreement. Five of eight %FFM predictive equations tested in DMD were accurate when compared with the DXA. It can be concluded that BIA is a validity method to evaluate patients with DMD.

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Section: Introductionmentioning

confidence: 99%

Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy

et al. 2020

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“…Regarding the %FM, a significant prevalence of high adiposity was found in all groups with increased fat mass with age. Likewise, Bernabe-García et al (Bernabe-García et al, 2019) found that as age advances, the fat mass increases while lean mass decreases. Besides, Caromano et al (Caromano et al, 2010) noticed that body fat accumulation is also influenced by a sedentary lifestyle and may not reflect weight change due to loss of lean mass.…”

Section: Discussionmentioning

confidence: 94%

When age matters: boys with Duchenne muscular dystrophy have growth delay and a fat mass accumulation, as they get older

Cunha

Grilo

Costa

et al. 2021

RSD

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Anthropometry and body composition evaluation in boys with Duchenne muscular dystrophy (DMD) are challenging, but crucial methods to evaluate the nutritional status, and better anthropometric reference values and body composition predictive equations are needed for this population. Based on these aspects, this study aimed to investigate the hypothesis that changes in anthropometric parameters and body composition of boys with DMD occur according to age. A cross-sectional study with 49 individuals diagnosed with DMD at the neurological outpatient facility at the Onofre Lopes University Hospital in Natal, Brazil, was performed between September 2016 and March 2019. These individuals underwent anthropometric and body composition evaluation. According to age, the participants were divided into four groups: G1 (2.6 - 8.2y), G2 (8.5 - 10.8y), G3 (11.0 - 14.0y), and G4 (15.9 - 23.0y). The parameters weight-for-age (W/A) (p=0.025), tricipital skinfold (TSF) (p=0.027), adductor pollicis muscle (p=0.041), and corrected arm muscle area (cAMA) (p=0.005) were different among the groups. Regarding anthropometric parameters, was prevalence in the categories of appropriate W/A and a height-for-age (H/A), and eutrophy for body mass index-for-age (BMI/A). For the TSF, there was a higher frequency of severe malnutrition or obesity. The cAMA indicated severe malnutrition in most individuals. As for %FM, high adiposity was more frequent, increasing over age groups (G1 to G4). The boys with DMD presented different patterns of anthropometric and body composition parameters. An increase of fat mass and a decrease of lean mass with age/disease progression were observed.

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“…In clinical practice, weight gain in DMD is often seen during the transition to the nonambulatory stage, suggesting decrease in physical activity may play an important role, with accompanying changes in body composition. Multiple studies confirm that patients in their non-ambulatory stage have a higher BMI-z score in general [5,11]. Other factors which can cause weight gain are corticosteroid use and caloric intake [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…al. [11] in a corticosteroid naive DMD population, for which they compared caloric intake with the recommended caloric intake. They found high caloric intake at preschool age compared to the recommended caloric intake and found no associations between caloric intake and prediction of body fat mass and lean mass.…”

Section: Introductionmentioning

confidence: 99%

BMI-z scores of boys with Duchenne muscular dystrophy already begin to increase before losing ambulation: a longitudinal exploration of BMI, corticosteroids and caloric intake

Opstal

Rodwell

Daalmeyer

et al. 2022

Neuromuscular Disorders

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Body composition and body mass index in Duchenne muscular dystrophy: Role of dietary intake

Abstract: Age dependent changes in BD in boys with DMD may be due to endogenous metabolic factors related to the underlying disease process and to disease-related mobility impairments. This article is protected by copyright. All rights reserved.

Cited by 24 publications

References 42 publications

Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy

Validity of bioelectrical impedance to estimate fat-free mass in boys with Duchenne muscular dystrophy

When age matters: boys with Duchenne muscular dystrophy have growth delay and a fat mass accumulation, as they get older

BMI-z scores of boys with Duchenne muscular dystrophy already begin to increase before losing ambulation: a longitudinal exploration of BMI, corticosteroids and caloric intake

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