Body composition and vertebral fracture risk in female patients treated with glucocorticoid

Abstract

The present study revealed that body composition is related to vertebral fracture risk in GC-treated patients. Lower % fat can be included in the determination of vertebral fractures in postmenopausal GC-treated patients. The influence of body composition on vertebral fracture risk may be different between the pre- and postmenopausal state in GC patients.

Urinary deoxypyridinoline is a BMD-independent marker for prevalent vertebral fractures in postmenopausal women treated with glucocorticoid

“…However, whether a change in serum OCN would be related to fracture risk has been unknown in GC-treated patients. In the present study, serum OCN levels were not different between the groups with and without vertebral fractures in both premenopausal and postmenopausal women treated with GC, which were compatible with our previous reports [15]. Moreover, serum OCN was not related to prevalent vertebral fractures in multivariable logistic regression analysis.…”

“…Long duration and continuous pattern of GC use demonstrated a significant fivefold increased risk of hip fractures and 5.9-fold increased risk of vertebral fractures [3]. Our previous study revealed that body composition is related to vertebral fracture risk in GC-treated patients [15]. Bone quality is influenced by accumulated micro damage, bone turnover effects, anomalies of bone matrix proteins, and degree of mineralization [16].…”

Type I diabetic bone phenotype is location but not gender dependent

“…It remains unclear why diabetic femurs and vertebrae exhibit diVerences in marrow adiposity, while sharing similar decreases in bone density. Consistent with the association of body composition to BMD (Kaji et al 2006;Reid 2002;Rosen and Bouxsein 2006), it is possible that the decrease in body, fat and/or muscle weights could contribute to the loss of BMD seen in diabetic males and females. For example, loss of peripheral fat depots could decrease levels of fat secreted factors such as leptin (Reid 2004;Yamauchi et al 2001).…”

Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus

“…Percent trunk fat (%trunk fat) was calculated by dividing trunk fat mass by total fat mass. The coefficient of variation (precision) of measurements of fat mass was 2.0% [20].…”