Body composition changes after laparoscopic adjustable gastric banding: what is the role of −174G&gt;C interleukin-6 promoter gene polymorphism in the therapeutic strategy?

Renzo, Laura Di; Carbonelli, Maria Grazia; Bianchi, Alessia; Iacopino, L; Fiorito, R; Daniele, Nicola Di; Lorenzo, Antonino De

doi:10.1038/ijo.2011.132

Cited by 25 publications

(17 citation statements)

References 56 publications

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“…Although larger study populations are needed to confirm this observation, this finding is comparable with our previous study [10], which has reported the relationship between the −174 G > C polymorphism of IL-6 and therapeutic response to bariatric surgery.…”

Section: Discussionsupporting

confidence: 90%

“…Poitou et al in 2005 showed a relationship between −174 G > C IL-6 polymorphism and circulating product in morbidly obese subjects, during weight loss after surgery [9]. In our previous study, at 6-month follow-up after LAGB surgery, according to IL-6 genotypes, no differences in fluid distribution were highlighted [10]. …”

Section: Discussionmentioning

confidence: 73%

“…The −174 G > C IL-6 polymorphism, which affects transcriptional regulation [8], may be sensed by the homeostatic feedback system that controls energy balance and may in turn contribute to some disturbances in weight regulation, particularly in a situation of negative energy balance, like induced weight loss [9]. We recently provided evidence that the promoter polymorphism of IL-6 (−174 G > C) gene is associated both with body composition and fluid distribution, in obese subjects, at baseline and at 6-month follow-up after LAGB, suggesting that LAGB was less effective if the subjects were carrying risk genotypes (C-carriers) for obesity [10]. …”

Section: Introductionmentioning

confidence: 99%

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Impact of the −174 G>C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding

et al. 2012

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Background. Recent data demonstrated that the −174 G > C IL-6 polymorphism may account for differences in the therapeutic response to laparoscopic adjustable gastric banding (LAGB) surgery. Objective. We investigated the impact of −174 G > C IL-6 polymorphism on weight loss, body composition, and fluid distribution changes in obese subjects after LAGB. Design and Outcome Measures. Twenty obese subjects were selected and studied at baseline and 3 months after LAGB. Genetic assessment of −174 G > C IL-6 polymorphism and anthropometric and bioelectrical impedance analysis were performed. Results. At baseline, C(+) carriers had a lower extracellular water (ECW) and higher intra-CW, phase angle (PA), reactance Xc, and Xc/height. LAGB surgery determined significant reductions in weight and BMI. After LAGB, in C(−) carriers, significant decreases in weight, BMI, and ECW and increases in BCM, BCMI, ICW, PA, and Xc/H were highlighted. In C(+) carriers, significant reductions in weight, BMI, ICW, and PA and increases in ECW, Na/K, resistance (R), and R/height were obtained. Significant higher reductions in BMI and Xc/H were observed in C(+) with respect to C(−) carriers. Conclusions. Genotyping of genetic variants, for example, the −174 G > C polymorphism of IL-6, gives the opportunity to predict therapeutic response, in terms of body composition outcomes after LAGB.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

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Impact of the −174 G>C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding

et al. 2012

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“…Resistance, reactance, impedance, phase angle, total body water (TBW), intracellular water (ICW), and extracellular water (ECW) were assessed by BIA phase sensitive system (BIA 101S, Akern/RJL Systems, Florence, Italy) [38, 39]. Impedance index (II) was evaluated with the following formula [40]:

\begin{matrix} I I = \frac{{h e i g h t}^{2} ({c m}^{2})}{r e s i s t a n c e (Ω)} . \end{matrix}

…”

Section: Methodsmentioning

confidence: 99%

Evidences of a New Psychobiotic Formulation on Body Composition and Anxiety

Colica

Avolio

Bollero

et al. 2017

Mediators of Inflammation

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Background Gut microbiota is implied in obesity, because of its ability to harvest energy from diet, and in the regulation of behavior. Given the link between gut microbiota, body composition, obesity, and anxiety, the aim of this study was to evaluate the effects of a new psychobiotic formulation. Methods Eligible patients were randomly divided into three groups: psychobiotics oral suspension group (POSG); dietary treatment group (DTG); combined treatment group (CTG). All subjects underwent body composition and psychological profile evaluation. Results Significant changes in body composition parameters in each group were relieved after all treatments. Hamilton anxiety rating scale (HAM-A) highlighted a significant reduction of the total score for all study population after treatments in POSG (p = 0.01) and CTG (p = 0.04). A reduction of HAM-A total score in anxious subjects in POSG or CTG and a significant reduction of positive subjects for HAM-A in POSG (p = 0.03) and in CDG (p = 0.01) were shown. Discussion Three-week intake of selected POS represents a good approach to solve problems related to obesity and behavior disorders. However, new clinical trials need to be performed on a larger population and for a longer period of treatment before definitive conclusions can be made. This trial is registered with NCT01890070.

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“…Previous investigations have shown that whole-body cryostimulation leads to an increase in the concentration of interleukin-6 (IL-6) [16,17]. Moreover, evidence indicates that IL-6 is linked to the regulation of fat mass [18]. Cryostimulation may intensify thermogenesis to maintain a balance between heat production and loss.…”

mentioning

confidence: 99%

Whole-body cryostimulation as an effective way of reducing exercise-induced inflammation and blood cholesterol in young men-->

Ziemann¹,

Olek²,

Grzywacz³

et al. 2014

European Cytokine Network

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Inflammation may accompany obesity and a variety of diseases, or result from excessive exercise. The aim of this study was to investigate the anti-inflammatory effect of whole-body cryostimulation on the inflammatory response induced by eccentric exercise under laboratory conditions. The study also sought to establish if cold treatment changes the lipid profile and modifies energy expenditure in young people. Eighteen healthy and physically active, college-aged men volunteered to participate in the experiment. They were divided into two subgroups: CRYsubmitted to whole-body cryostimulation, and CONT-a control group. Both groups performed eccentric work to induce muscle damage. Blood samples were collected before and 24 h after the exercise. Over the five days that followed, the CRY group was exposed to a series of 10 sessions in a cryogenic chamber (twice a day, for 3 min, at a temperature of -110 • C). After this period of rest, both groups repeated a similar eccentric work session, following the same schedule of blood collection. The perceived pain was noted 24h after each session of eccentric workout. A 30-minute step up/down work-out induced delayed-onset muscle soreness in both groups. The five-day recovery period accompanied by exposure to cold significantly enhanced the concentration of the anti-inflammatory cytokine IL-10. It also led to a pronounced reduction in levels of the pro-inflammatory cytokine IL-1␤, and reduced muscle damage. The values for IL-10 before the second bout of eccentric exercise in the CRY group were 2.0-fold higher in comparison to baseline, whereas in the CONT group, the concentration remained unchanged. Furthermore, blood concentrations of the pro-inflammatory cytokine IL-1␤ fell significantly in the CRY group. The main finding of this study was that a series of 10 sessions of whole body cryostimulation significantly reduced the inflammatory response induced by eccentric exercise. The lipid profile was also improved, but there was no effect on energy expenditure during the exercise.

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Body composition changes after laparoscopic adjustable gastric banding: what is the role of −174G>C interleukin-6 promoter gene polymorphism in the therapeutic strategy?

Cited by 25 publications

References 56 publications

Impact of the −174 G>C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding

Impact of the −174 G>C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding

Evidences of a New Psychobiotic Formulation on Body Composition and Anxiety

Whole-body cryostimulation as an effective way of reducing exercise-induced inflammation and blood cholesterol in young men-->

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