Body Composition Changes in Adult Females after Lifestyle Intervention Are Influenced by the NYD-SP18 Variant

Suchánek, Pavel; Lánská, Věra; Hubáček, J.

doi:10.21101/cejph.a4105

Cited by 10 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recently, the association has been detected in males, but not in females, in the Czech post-MONICA study [ 7 ]. The possible role of the NYD-SP18 in the determination of BMI has been further suggested in a small intervention study [ 8 ] of overweight non-diabetic females; the results suggest that common homozygotes profit more from the intensive life style intervention than carriers of the minor A allele.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the additive effect between this SNP and 1st intron polymorphism of the FTO gene on BMI values has been detected [ 7 ]. Finally, a small intervention study in females suggested that NYD-SP18 polymorphism could be a significant predictor of positive body composition changes after a short-term intensive life style intervention [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lack of Association between NYD-SP18 Variant and Obesity. The Health Alcohol and Psychosocial Factors in Eastern Europe Study

et al. 2016

View full text Add to dashboard Cite

Aim: To replicate the finding that the polymorphism rs6971091 within the NYD-SP18 gene is associated with body mass index (BMI). Method: We analysed data of 29,284 adults (46.2% of males, mean age 58.9 (SD 7.3), mean BMI 28.6 (5.0 kg/m²)) examined within the Health Alcohol and Psychosocial Factors in Eastern Europe study in the Czech Republic, Poland, Lithuania and Russia. Results: BMI did not differ by rs6971091 genotype. In men, the mean BMI (SEs) in GG, GA and AA carriers were 27.8 (0.05), 27.9 (0.06) and 27.9 (0.14) kg/m², respectively, (p = 0.26); in women, the corresponding values were 29.2 (0.06), 29.1 (0.07) and 29.1 (0.16), p = 0.57. In Czech subjects (n = 6,752), for whom the FTO rs17817449 genotype was available, there was no interaction between the NYD-SP18 and FTO polymorphisms in determination of BMI. Adjustment for age, energy and fat intake and physical activity did not materially change the results. There was no association of the NYD-SP18 genotype with waist-hip ratio. Conclusion: This study in a large Slavonic population sample suggests that the rs6971091 variant within the NYD-SP18 gene is not an important determinant of obesity in middle-aged persons.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lack of Association between NYD-SP18 Variant and Obesity. The Health Alcohol and Psychosocial Factors in Eastern Europe Study

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The program was based on supervised ten-week lifestyle modification interventions. [18][19][20] Dietary intervention involved adjusting energy intake to the age-related optimum (max. 7500 kJ/day).…”

Section: Interventionmentioning

confidence: 99%

Short-term trajectories of exercise-induced plasma lipid changes in overweight females, with a focus on HDL-cholesterol

Suchánek¹,

Lánská²,

Stávek³

et al. 2021

Adv Clin Exp Med

View full text Add to dashboard Cite

Background. Increased levels of plasma lipoproteins are among some of the modifiable risk factors for cardiovascular disease (CVD). Dietary changes and increased physical activity are the most powerful nonpharmacological interventions for achieving optimal plasma lipid levels. Objectives.To investigate the effect of an intensive short-term lifestyle intervention on plasma lipid trajectories in overweight non-diabetic females. Materials and methods.A total of 202 healthy overweight (body mass index (BMI) >27.5 kg/m 2 ) females underwent an intensive short-term (ten-week) intervention (at least 4 units of one-hour exercise activity weekly at optimal energy intake) aimed at lowering body weight. Plasma lipid (total cholesterol (TC), lowdensity-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol (HDL-C), and triglycerides (TG)) levels were examined at baseline and every 2 weeks over the course of the ten-week intervention.Results. There was a significant decrease in BMI (Δ -4.7%, p < 0.001) and body weight (Δ -4.9%, p < 0.001) after the intervention. Positive changes (decreases) in TC (Δ -8%, p < 0.001), TG (Δ -9%, p < 0.001) and LDL-C (Δ -11%, p < 0.001) were observed immediately after 2 weeks, but levels did not decrease further thereafter. In contrast, HDL-C did not increase as expected: after 2 weeks of intervention, we observed a significant decrease of about 6% (p < 0.001) followed by a slow return to baseline values. But even after 10 weeks of intervention, HDL-C values had not reached the values detected at baseline. Conclusions.In overweight females, HDL-C decreased after short-term intensive lifestyle intervention. To confirm the protective effect of increased physical activity, plasma lipids need to be examined over a longer time period.

show abstract

Baseline Leptin/Adiponectin Ratio is a Significant Predictor of BMI Changes in Children/Adolescents after Intensive Lifestyle Intervention

Pejšová

Hubacek

Zemánková

et al. 2019

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

Introduction Abdominal obesity is a strong cardiometabolic risk factor that often occurs as early as in childhood. The negative effect of abdominal obesity on the metabolism is partially mediated by changes to the production of the major adipocyte hormones leptin and adiponectin. Leptin/adiponectin imbalance is associated with increased risk of developing obesity and type 2 diabetes mellitus. Aim To determine whether leptin, adiponectin and the leptin/adiponectin ratio are significant predictors of body weight loss in intensively treated children/adolescents. Methods 183 paediatric overweight or obese patients (71 boys and 112 girls), aged 7–16 years, were enrolled in a one-month intensive lifestyle intervention programme. Participants reduced their energy intake and engaged in a supervised exercise programme consisting of 5 physical activity units per day. The subjects were examined both before and after the intervention. Results The mean BMI decrease achieved was−2.38±0.07 kg/m² (P<0.01). The decrease in plasma leptin concentration was−16.59±0.84 ng/mL (P<0.001) and CRP−0.38±0.04 mg/L (P<0.001). Changes in adiponectin concentrations were not statistically significant. The baseline leptin/adiponectin ratio was a significant predictor of decreases in body weight (P<0.005), BMI (P<0.0001) and waist circumference (P<0.05). Conclusion The leptin/adiponectin ratio at baseline may be a useful predictor of results from interventions focused on decreasing BMIs in children/adolescents.

show abstract

Body Composition Changes in Adult Females after Lifestyle Intervention Are Influenced by the NYD-SP18 Variant

Abstract: Overweight/obese female carriers of the NYD-SP18 rs6971091 GG genotype exhibited a more beneficial response to the intensive lifestyle intervention than others.

Cited by 10 publications

References 15 publications

Lack of Association between <b><i>NYD-SP18</i></b> Variant and Obesity. The Health Alcohol and Psychosocial Factors in Eastern Europe Study

Lack of Association between <b><i>NYD-SP18</i></b> Variant and Obesity. The Health Alcohol and Psychosocial Factors in Eastern Europe Study

Short-term trajectories of exercise-induced plasma lipid changes in overweight females, with a focus on HDL-cholesterol

Baseline Leptin/Adiponectin Ratio is a Significant Predictor of BMI Changes in Children/Adolescents after Intensive Lifestyle Intervention

Contact Info

Product

Resources

About