BackgroundPeople with HIV (PWH) are prone to mobility impairments and physical dysfunction, with the loss of skeletal muscle quantity and quality being a major contributor to the dysfunction. Assessment of skeletal muscle is an important component of care for this patient population for early intervention and treatment. The use of non‐invasive imaging techniques to evaluate skeletal muscle, such as dual X‐ray absorptiometry, computer tomography and magnetic resonance imaging, has increased in popularity in recent years.PurposeThis narrative review synthesizes the use of these techniques and summarizes the associations between outcomes from these imaging modalities and physical function in PWH.