Body Composition in 70-Year-Old Adults Responds to Dietary β-Hydroxy-β-Methylbutyrate Similarly to That of Young Adults

Vukovich, Matthew D.; Stubbs, Nancy B.; Bohlken, R M.

doi:10.1093/jn/131.7.2049

Cited by 186 publications

(160 citation statements)

References 17 publications

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“…However, despite some support for the efficacy of HMB in conditions of increased loading, positive adaptations have not always been evident. Similar improvements in lean tissue between RT vs. HMB + RT groups have been reported in studies of comparable HMB dosage and RT frequency/duration (Jowko et al, 2001;Kreider et al, 1999;Ransone et al, 2003;Vukovich et al, 2001). Thus, the collective body of work addressing the ergogenic effect of HMB on loaded skeletal muscle appears equivocal at best.…”

Section: Discussionsupporting

confidence: 74%

β-Hydroxy-β-Methylbutyrate Did Not Enhance High Intensity Resistance Training-Induced Improvements in Myofiber Dimensions and Myogenic Capacity in Aged Female Rats

Kim

Park

Lee

et al. 2012

Molecules and Cells

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Older women exhibit blunted skeletal muscle hypertrophy following resistance training (RT) compared to other age and gender cohorts that is partially due to an impaired regenerative capacity. In the present study, we examined whether β-hydroxy-β-methylbutyrate (HMB) provision to aged female rodents would enhance regenerative mechanisms and facilitate RT-induced myofiber growth. Nineteen-month old female Sprague-Dawley rats were randomly divided into three groups: HMB (0.48 g/kg/d; n = 6), non-HMB (n = 6), and control (n = 4). HMB and non-HMB groups underwent RT every third day for 10 weeks using a ladder climbing apparatus. Whole body strength, grip strength, and body composition was evaluated before and after RT. The gastrocnemius and soleus muscles were analyzed using magnetic resonance diffusion tensor imaging, RT-PCR, and immunohistochemistry to determine myofiber dimensions, transcript expression, and satellite cells/myonuclei, respectively. ANOVAs were used with significance set at p < 0.05. There were significant time effects (pre vs. post) for whole body strength (+262%), grip strength (+17%), lean mass (+20%), and fat mass (-19%). Both RT groups exhibited significant increases in the mean myofiber cross-sectional area (CSA) in the gastrocnemius and soleus (+8-22%) compared to control. Moreover, both groups demonstrated significant increases in the numbers of satellite cells (+100-108%) and myonuclei (+32%) in the soleus but not the gastrocnemius. A significant IGF-I mRNA elevation was only observed in soleus of the HMB group (+33%) whereas MGF and myogenin increased significantly in both groups (+32-40%). Our findings suggest that HMB did not further enhance intense RT-mediated myogenic mechanisms and myofiber CSA in aged female rats.

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Section: Discussionsupporting

confidence: 74%

β-Hydroxy-β-Methylbutyrate Did Not Enhance High Intensity Resistance Training-Induced Improvements in Myofiber Dimensions and Myogenic Capacity in Aged Female Rats

Kim

Park

Lee

et al. 2012

Molecules and Cells

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“…3 Beta-hydroxy-␤-methylbutyrate (HMB) is a leucine metabolite that enhances strength and muscle mass gains induced by strength exercise. 12,33,50 HMB, in combination with arginine and glutamine, reversed muscle wasting associated with cancer cachexia 29 and HIV-wasting syndrome. 6 HMB also reduced creatine kinase activity following various types of exercise.…”

mentioning

confidence: 98%

Nutritional therapy improves function and complements corticosteroid intervention in mdx mice

et al. 2005

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Corticosteroid therapy for Duchenne muscular dystrophy is effective but associated with long-term side effects. To determine the potential therapeutic benefit from four nutritional compounds (creatine monohydrate, conjugated linoleic acid, ␣-lipoic acid, and ␤-hydroxy-␤-methylbutyrate) alone, in combination, and with corticosteroids (prednisolone), we evaluated the effects on several variables in exercising mdx mice. Outcome measures included grip strength, rotarod performance, serum creatine kinase levels, muscle metabolites, internalized myonuclei, and retroperitoneal fat pad weight. In isolation, each nutritional treatment showed some benefit, with the combination therapy showing the most consistent benefits. Prednisolone and the combination therapy together provided the most consistent evidence of efficacy; increased peak grip strength (P Ͻ 0.05), decreased grip strength fatigue (P Ͻ 0.05), decreased number of internalized myonuclei (P Ͻ 0.01), and smaller retroperitoneal fat pad stores (P Ͻ 0.001). This study provided evidence for therapeutic benefit from a four-compound combination therapy alone, and in conjunction with corticosteroids in the mdx model of DMD.

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“…Alguns estudos demonstraram que suplementação de HMB durante o treinamento contra-resistência resulta em maior crescimento muscular e concomitante aumento na força em sujeitos destreinados [13][14][15][16] .…”

Section: Efeitos Do Hmb Em Indivíduos Iniciando O Programa De Treinamunclassified

“…Vukovich et al 16 realizaram outro estudo com o objetivo de analisar o efeito da suplementação de HMB na composição corporal de idosos (≥70 anos). Trinta e um homens e mulheres divididos em grupos HMB (3,0g por dia) e placebo realizaram treinamento contra-resistência cinco vezes por semana, durante oito semanas.…”

Section: Efeitos Do Hmb Em Indivíduos Iniciando O Programa De Treinamunclassified

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Efeitos da suplementação de b-hidroxi-b-metilbutirato sobre a força e a hipertrofia

Álvares

Meirelles

2008

Rev. Nutr.

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Efeitos da suplementação de β-hidroxi-β-metilbutirato sobre a força e a hipertrofia Effects of β-hydroxy-β-methylbutyrate supplementation on strength and hypertrophyThiago da Silveira ALVARES 1 Cláudia de Mello MEIRELLES 1,2,3 R E S U M OO β-hidroxi-β-metilbutirato é um metabólito da leucina estudado devido aos seus efeitos anticatabólicos e possíveis implicações sobre os ganhos de força e massa muscular associados ao treinamento contra--resistência (conhecido como musculação). O objetivo deste trabalho foi revisar a literatura referente à suplementação de β-hidroxi-β-metilbutirato e os seus efeitos sobre força e hipertrofia em adultos jovens e idosos iniciantes ou treinados em treinamento contra-resistência. Estudos em indivíduos iniciando um programa de treinamento contra-resistência sugerem que a suplementação diária de 1,5 a 3,0g de β-hidroxi-β-metilbutirato pode trazer benefício ergogênico durante as primeiras quatro ou cinco semanas. Entretanto, à medida que o programa de treinamento evolui, tais efeitos não permanecem e os ganhos de força e massa muscular são proporcionados apenas pelo treinamento contra-resistência. Em indivíduos treinados, os resultados parecem não ser os mesmos, uma vez que, desde o início da suplementação, o β-hidroxi-β-metilbutirato não demonstra qualquer benefício adicional aos induzidos pelo treinamento contra-resistência. Alguns efeitos do β-hidroxi-β-metilbutirato na redução do colesterol total e lipoproteína de baixa densidade também foram observados, porém, devido às poucas evidências, não há recomendações para tal finalidade. Nenhum efeito adverso da suplementação foi observado, sendo, aparentemente, segura, contudo a maioria dos estudos foi realizada em curto prazo (menos de 4 semanas) e em indivíduos destreinados. Assim, mais estudos são necessários para esclarecer o mecanismo fisiológico por meio do qual o β-hidroxi-β-metilbutirato exerce seus efeitos anticatabólicos em destreinados e para observar possíveis efeitos adversos.

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Body Composition in 70-Year-Old Adults Responds to Dietary β-Hydroxy-β-Methylbutyrate Similarly to That of Young Adults

Cited by 186 publications

References 17 publications

β-Hydroxy-β-Methylbutyrate Did Not Enhance High Intensity Resistance Training-Induced Improvements in Myofiber Dimensions and Myogenic Capacity in Aged Female Rats

β-Hydroxy-β-Methylbutyrate Did Not Enhance High Intensity Resistance Training-Induced Improvements in Myofiber Dimensions and Myogenic Capacity in Aged Female Rats

Nutritional therapy improves function and complements corticosteroid intervention in mdx mice

Efeitos da suplementação de b-hidroxi-b-metilbutirato sobre a força e a hipertrofia

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