Body composition measures and cardiovascular risk in high-risk ethnic groups

Diemer, Frederieke S.; Brewster, Lizzy M.; Haan, Yentl C.; Oehlers, G.P.; Montfrans, Gert A. van; Venrooij, Lenny M. W. Nahar-van

doi:10.1016/j.clnu.2017.11.012

Cited by 20 publications

(14 citation statements)

References 26 publications

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“…[44] Diabetes is also a known correlate of arterial stiffness, [19,[38][39][40][41][42][43] which is thought to partially be due to insulin's ability to stimulate the sympathetic nervous system, resulting in elevated BP and PWV. [45,46] Measures of adiposity were not independently associated with baPWV, even though previous studies [43,[47][48][49][50][51] have suggested that obesity and/or greater ectopic fat are associated with arterial stiffness. However, little of this previous research has been conducted in African ancestry men.…”

Section: Discussionmentioning

confidence: 98%

Arterial stiffness and hypertension status in Afro-Caribbean men

Kuipers

Miljkovic

Barinas‐Mitchell

et al. 2019

Journal of Hypertension

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Objective: African ancestry individuals are at high risk for hypertensive cardiovascular disease (CVD) and could benefit from early detection of arterial stiffening. We tested the association between the 2017 ACC/AHA hypertension categorizations, which include new blood pressure (BP) cutoffs and a definition for elevated BP, and arterial stiffness in 772 Afro-Caribbean men aged 50+ years (mean 64 years). Methods: Arterial stiffness was assessed by brachial-ankle pulse-wave velocity (PWV) using a waveform analyzer. Hypertension groups were based on the 2017 ACC/AHA guidelines and by pharmacologic control status. Multiple linear/logistic regression was used to determine the association of PWV with BP and hypertension. Results: Mean(SD) PWV was 1609(298) cm/s and was independently correlated with age, systolic BP, pulse, diabetes, height, and alcohol intake (all P<0.02). After adjusting for these, in men aged ≥65 years, those with stage 1 or uncontrolled stage 2 hypertension had significantly greater PWV than all other groups (all P<0.05). Men with controlled hypertension had similar PWV to those with elevated BP (P=0.7); however, this was significantly greater than men with normal BP (all P<0.05). Patterns were similar, but with smaller effect sizes, in men aged <65 years (all P<0.05 except controlled hypertension versus elevated or normal BP were not significant). Conclusions: In these high-risk Afro-Caribbeans: 1) stage 1 hypertension is associated with increased PWV, which supports the new guidelines; and, 2) pharmacologic control appears to partially protect men from increased PWV. Longitudinal studies are needed to determine optimal PWV and timing of anti-hypertensive treatment for preventing future CVD.

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Section: Discussionmentioning

confidence: 98%

Arterial stiffness and hypertension status in Afro-Caribbean men

Kuipers

Miljkovic

Barinas‐Mitchell

et al. 2019

Journal of Hypertension

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“…The UKPDS-based CV risk calculations were consistently related only to the BMI and WHtR, while BF% was related mainly to the risk for CHD (fatal or not), and the FM, FFM and TBW -mainly to the risk for stroke (fatal or not). A study tested the adiposity markers versus the UKPDSbased risk of CHD in type 2 diabetes patients and found that the associations of weight, BMI and WHR did not hold in their sample [34][35][36][37]. More publications included FRS-based risk calculations [34].…”

Section: Association Of Obesity Indices Body Composition and Cv-riskmentioning

confidence: 99%

“…In a sample of Chinese women the WHtR was best correlated to the FRS-based risk [35]. WHtR was found as the best predictor of FRSbased calculations in another study, followed by the WC [36]. Another study of FRS in high-risk ethnic groups highlighted the best predictive value of WHR, while the WC was linked best to the arterial stiffness, and BMI was of value in specific subgroups only [37].…”

Section: Association Of Obesity Indices Body Composition and Cv-riskmentioning

confidence: 99%

Body composition indices and cardiovascular risk in type 2 diabetes. CV biomarkers are not related to body composition

et al. 2020

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AbstractBackgroundThis study aims to explore the correlations of body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR) and body composition with levels of asymmetric dimethylarginine (ADMA), endothelin 1(ET-1), N-terminal brain natriuretic pro-peptide (NT-proBNP) and calculated cardiovascular risks.Methods102 women and 67 men with type 2 diabetes participated. Serum levels of NT-proBNP were measured by electro-hemi-luminescence while ELISA were used for ADMA and ET-1. Cardiovascular risks were calculated using the Framingham Risk Score (FRS), the UKPDS 2.0 and the ADVANCE risk engines. Statistical analysis was performed on an IBM SPSS 19.0.ResultsThe BMI outperformed all other indices of obesity (WC, WHtR, WHR), as well as body composition parameters (body fat%, fat mass, fat free mass and total body water) in relation to the estimated risks for coronary heart disease and stroke, based on different calculators. The correlations of the obesity indices with the serum cardiovascular biomarkers were not significant except for BMI and fat mass versus ET-1, and for fat free mass and total body water versus ADMA.ConclusionsThe WC, WHR, WHtR, BF%, FM and FFM apparently do not add significant information related to the levels of cardiovascular biomarkers or the calculated CV-risks.

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“…Evidence suggests that body composition has impact on the prevalence and development of arterial stiffness [9][10][11][12][13][14]. More specifically, previous studies which explored the association between muscle mass and PWV showed consensus preliminarily.…”

Section: Introductionmentioning

confidence: 99%

Low skeletal muscle mass is associated with arterial stiffness in community-dwelling Chinese aged 45 years and older

Yang¹,

Zhang²,

Ding³

et al. 2020

BMC Public Health

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Background: Evidence suggests that body composition has impact on arterial stiffness. However, evidence in Chinese are limited, and results remain controversial. The aim of our study is to investigate whether skeletal muscle mass is associated with arterial stiffness in Chinese community-dwelling men and women aged 45 years and older. Methods: In this cross-sectional study, 20,477 participants (age range: 45-80 years, 68.8% women) were included in the analysis. Brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness was measured using a waveform device. Total muscle mass and muscle mass of arm, leg and trunk were measured by bioelectrical impedance analysis. Height and weight were measured and appendicular skeletal muscle mass index (ASMI) was calculated as appendicular skeletal muscle mass (sum of arm and leg muscle mass) divided by height square. Results: After adjustment for age, body fat percentage, systolic blood pressure and diastolic blood pressure, ASMI was negatively associated with baPWV [β (SE) for men: − 0.208 (0.016), p < 0.0001; for women: − 0.245 (0.012), p < 0.0001]. High ASMI was a protective factor for the presence of arterial stiffness (defined as baPWV) [OR (95%CI) for men: 0.730 (0.682, 0.782), p < 0.0001; women: 0.634 (0.593, 0.677), p < 0.0001]. Similar associations were found between quantity of muscle mass (total and appendicular muscle mass, muscle mass of arm, leg and trunk) and arterial stiffness in men and women after further adjustment for height (all p < 0.0001). Conclusion: Low skeletal muscle mass is associated with increased risk of arterial stiffness in Chinese communitydwelling adults aged 45 years and older.

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Body composition measures and cardiovascular risk in high-risk ethnic groups

Cited by 20 publications

References 26 publications

Arterial stiffness and hypertension status in Afro-Caribbean men

Arterial stiffness and hypertension status in Afro-Caribbean men

Body composition indices and cardiovascular risk in type 2 diabetes. CV biomarkers are not related to body composition

Low skeletal muscle mass is associated with arterial stiffness in community-dwelling Chinese aged 45 years and older

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