Body composition of Slovak midlife women with cardiovascular complications

Drozdová, Darina; Daňková, Zuzana; Čerňanová, Veronika Candráková; Siváková, Daniela

doi:10.1515/anre-2016-0013

Cited by 6 publications

(1 citation statement)

References 30 publications

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“…Obesity is a global issue of great concern, and it is becoming more serious as living standards rise ( 3 ). Obesity has been shown to cause a variety of diseases, including cardiovascular ( 4 ) and cerebrovascular disease ( 5 ), diabetes ( 6 ), obstructive sleep apnea syndrome ( 7 ), and metabolic disorders ( 8 ). Observational studies have shown that NSOM may be associated with obesity, most of which is concentrated in the pediatric population ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Obesity and adiposity promote the development of non-suppurative otitis media: a Mendelian randomization study

Yan,

Chen

2024

Front. Med.

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BackgroundObservational studies have found that obesity is associated with the development of non-suppurative otitis media (NSOM), but the causality and pathogenesis are unclear. This study aimed to investigate the association between obesity, lipid metabolism, and NSOM at the genetic level.MethodsWe performed a bidirectional two-sample Mendelian randomization (MR) study to examine the causal relationship between obesity, lipid metabolism-related factors, and NSOM by using the datasets obtained from the IEU Open genome-wide association studies (GWAS) Project. Furthermore, a multivariate MR (MVMR) analysis on lipid indicators was conducted to validate the results. We then used obesity or body mass index (BMI) as the exposure and NSOM as the outcome to search for possible mediators in lipids and adipokines.ResultsUsing NSOM as the outcome, we found nine positive exposure results related to obesity and lipid metabolism. Among them, obesity, BMI, body fat percentage, waist circumference, hip circumference, and resistin were risk factors, while apolipoprotein A1 (apoA1), high-density lipoprotein cholesterol (HDL-C), and nerve growth factor (NGF) were protective factors. Then, we used the obesity and lipid metabolism-related factors as outcomes and NSOM as the exposure to perform the MR analysis, which failed to obtain positive results. In the MVMR analysis, we found that HDL cholesterol and apoA1 remained causally associated with NSOM after correction for other potential confounders. Simultaneously, when obesity or BMI was used as the exposure and NSOM as the outcome, HDL cholesterol or apoA1 served as mediators through a two-step MR analysis. The MR analysis for mediation, obesity, and BMI reduced the production of HDL or apoA1, which served as protective factors affecting the development of NSOM.ConclusionAt the genetic level, obesity and adiposity may promote the development of NSOM, while NSOM has no effect on obesity and adiposity. Obesity can also encourage the progress of NSOM by reducing HDL cholesterol/apoA1. Resistin may be a potential risk factor for NSOM, whereas NGF may be a potential protective factor.

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Section: Introductionmentioning

confidence: 99%

Obesity and adiposity promote the development of non-suppurative otitis media: a Mendelian randomization study

Yan,

Chen

2024

Front. Med.

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Phase angle of bioimpedance at 50 kHz is associated with cardiovascular diseases: systematic review and meta-analysis

et al. 2022

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Genetic Evidence of Obesity-Induced Chronic Wounds Mediated by Inflammatory Biomarkers

Xu,

Ding,

Tong

et al. 2024

Biological Research For Nursing

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Background: Obese patients are increasingly recognized as being at higher risk for skin diseases, particularly chronic wounds. While the exact mechanisms remain unclear, obesity is suspected to influence the development of chronic injuries via inflammatory biomarkers. Single nucleotide polymorphisms (SNPs) may further influence gene expression, protein function, and levels of inflammatory biomarkers through various mechanisms, thereby modulating inflammatory responses that contribute to wound pathogenesis. Methods: A two-sample two-step Mendelian Randomization (MR) was employed to explore the causal relationship between obesity and chronic wounds, focusing on the mediating role of inflammatory biomarkers. SNPs were used as instrumental variables (IVs) to infer causality. Obesity-related genetic data were sourced from the UK Biobank and GIANT consortium. Genome-wide association studies provided data on 92 inflammatory biomarkers, involving 14,824 and 575,531 individuals. Pressure injuries, lower limb venous ulcers, and diabetic foot ulcer data were obtained from FinnGen R10 and the Pan-UK Biobank. Results: Obesity significantly increased the risk of pressure injuries, lower limb venous ulcers, and diabetic foot ulcers. CCL19, hGDNF, IL-12B, and TNFRSF9 were identified as mediators in obesity-induced lower limb venous ulcers. Conclusion: This study provides genetic evidence that obesity leads to lower limb venous ulcers via inflammatory biomarkers, suggesting potential therapeutic targets for intervention.

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Body composition of Slovak midlife women with cardiovascular complications

Cited by 6 publications

References 30 publications

Obesity and adiposity promote the development of non-suppurative otitis media: a Mendelian randomization study

Obesity and adiposity promote the development of non-suppurative otitis media: a Mendelian randomization study

Phase angle of bioimpedance at 50 kHz is associated with cardiovascular diseases: systematic review and meta-analysis

Genetic Evidence of Obesity-Induced Chronic Wounds Mediated by Inflammatory Biomarkers

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