Body Composition of Very Low‐Birth‐Weight Infants Fed Fortified Human Milk: A Pilot Study

Liu, Chunyan; Ehrlich, Shelley; Fields, Christopher J.; Fields, Trayce; Poindexter, Brenda B.

doi:10.1002/jpen.1931

Cited by 6 publications

(7 citation statements)

References 31 publications

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“…In a recent study of 30 neonates, an increased intake of donor milk was associated with higher body fat percentage but did not have an impact on fat-free mass ( 28 ) . In this study, McNelis et.…”

Section: Discussionmentioning

confidence: 99%

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Effects of human milk on body composition and growth in very low birthweight infants

et al. 2022

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Objective: To compare body composition and growth in very low birth weight infants according to their source of human milk: maternal expressed breast milk (MEBM) versus donor breast milk (DBM). We hypothesized that infants fed predominately MEBM would exhibit reduced body fat percentage compared to those fed predominately DBM. Methods: Premature infants weighing ≤1500g on an exclusive human milk diet were enrolled in a single-center study between 2017 and 2021. Demographic data and anthropometric measurements were collected. All infants underwent body composition analysis via dual energy x-ray absorptiometry at 36 weeks corrected post menstrual age. Results: 60 infants were enrolled and 48 were included in the primary analysis. No differences were detected in percent body fat (14% vs.12%, p=0.7) or fat-free mass (2050g vs. 2130g p=0.7). Both groups displayed similar growth and anthropometric measurements. Caloric and macronutrient intake between groups was similar. Conclusion: In the cohort of patients studied, no differences were observed in percent body fat based on primary human milk type intake in the first 28 postnatal days. Further investigation is required in a larger population of exclusive human milk fed preterm infants to determine if body composition differences exist based on an infant’s primary human milk source.

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Section: Discussionmentioning

confidence: 99%

“…In this study, McNelis et. al, fortified the infant’s milk with a bovine based product and were unable to maintain a consistent caloric density of donor milk ( 28 ) . This approach differs from the one used in our study design.…”

Section: Discussionmentioning

confidence: 99%

Effects of human milk on body composition and growth in very low birthweight infants

et al. 2022

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“…Collected data included a retrospective convenience sample from three hospitals where care is provided by CCHMC Perinatal Institute physicians in 2013–2019: CHCMC, a 76‐bed level IV referral unit; the University of Cincinnati Hospital, a 50‐bed level III inborn unit; and Good Samaritan Hospital, a 60‐bed level III unit 18 . All centers use the same feeding protocol (Figure S1).…”

Section: Methodsmentioning

confidence: 99%

“…Collected data included a retrospective convenience sample from three hospitals where care is provided by CCHMC Perinatal Institute physicians in 2013-2019: CHCMC, a 76-bed level IV referral unit; the University of Cincinnati Hospital, a 50-bed level III inborn unit; and Good Samaritan Hospital, a 60-bed level III unit. 18 All centers use the same feeding protocol (Figure S1). Customized PN is started on the first day of life with a goal glucose infusion rate of 4-8 mg/kg/min; amino acids (TrophAmine) at 2.5 g/kg/day, which was advanced to 3.5 g/kg/day; and Intralipid (Fresenius Kabi/Baxter) at 1 g/kg/day, which was advanced to 3 g/kg/day.…”

Section: Cchmc-cincinnati Ohiomentioning

confidence: 99%

Effect of parenteral nutrition duration on patterns of growth and body composition in very low‐birth‐weight premature infants

Alja'nini

Merlino-Barr

Brumfiel

et al. 2021

J Parenter Enteral Nutr

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Background: Parenteral nutrition (PN) is essential to support premature infants' growth and varies with enteral nutrition (EN) advancement rates. Data on PN duration's impact on premature infants' growth are limited. The aim of this multicenter observational study was to determine the effect of early PN duration on body composition at term corrected gestational age (CGA) in very low-birth-weight (VLBW) premature infants.Methods: VLBW infants exposed to PN in the first week of life and exposed to significantly different EN regimens were divided into two groups on the basis of early PN duration. Infants with a birth weight (BW) <1000 g and PN duration <28 days and infants with a BW 1000-1500 g and PN duration <14 days were assigned to the "short-PN" group. Infants receiving PN for longer durations were assigned to the "long-PN" group. Body composition was assessed via air displacement plethysmography at term CGA or before discharge.Results: Sixty-two and 53 infants were assigned to the short-PN and long-PN groups, respectively. The two groups were significantly different in BW and GA, so a nested case-control study was conducted after matching 36 infant pairs. Infants in the long-PN group had significantly lower fat-free mass (FFM) z-scores, but both groups had comparable fat mass (FM) z-scores. Long PN was a significant negative predictor of FFM z-score in the multivariate regression analysis. Conclusion:In VLBW premature infants, PN duration is negatively associated with FFM z-scores at term CGA without affecting FM z-scores.

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“…have demonstrated that infants fed fortified DHM have impaired short-term growth outcomes compared to infants fed fortified MOM (17,(19)(20)(21)(22)(23).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Transient Hypoglycemia and Biochemical Differences in Infants Less Than 1,250 G at Birth Fed Human Milk with Human Milk–Derived Fortifier versus Cow Milk–Derived Fortifier

Chang,

Tetarbe,

Barton

et al. 2023

Am J Perinatol

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Objective: Fortification of human milk with either human milk-derived fortifier (HMDF) or cow milk-derived fortifier (CMDF) is important in preterm infants. Objective is to compare the incidence of hypoglycemia, and biochemical values in infants less than 1250g at birth fed HMDF versus CMDF. Study design: Retrospective cohort study on infants less than 1250g at birth who were fed with HMDF or CMDF. Hypoglycemia was defined as blood glucose (BG) level equal to or less than 60 mg/dL within 72 hours of full enteral feeds when off TPN and intravenous fluids. Results: Ninety infants were enrolled (HMDF=61; CMDF=29). HMDF group had a higher rate of hypoglycemia (46% vs. 24%; p=0.048) after achievement of full enteral feeding. The median minimum blood glucose (BG) was lower (61 vs. 71; p=<0.01); while blood urea nitrogen (12 vs. 6; p=<0.01); and albumin (3.1 vs. 2.7; p=<0.01) were higher in HMDF group compared to CMDF. Conclusions: At full enteral feedings in infants less than 1250g at birth, a HMDF diet may predispose to hypoglycemia needing intervention. Close monitoring of BG levels once off parenteral nutrition is recommended.

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Body Composition of Very Low‐Birth‐Weight Infants Fed Fortified Human Milk: A Pilot Study

Cited by 6 publications

References 31 publications

Effects of human milk on body composition and growth in very low birthweight infants

Effects of human milk on body composition and growth in very low birthweight infants

Effect of parenteral nutrition duration on patterns of growth and body composition in very low‐birth‐weight premature infants

Transient Hypoglycemia and Biochemical Differences in Infants Less Than 1,250 G at Birth Fed Human Milk with Human Milk–Derived Fortifier versus Cow Milk–Derived Fortifier

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