Body condition of late pregnant gilts affects the expression of selected adipokines and their receptors in mammary fat and backfat tissues1

The prolactin receptor: A cross‐species comparison of gene structure, transcriptional regulation, tissue‐specificity, and genetic variation

“…By contrast, PRLR expression in rabbit adipose tissue is low and static during gestation 136 . In pigs, both PRLR ‐LF and ‐SF were expressed in subcutaneous lumbar adipose, also at low levels, 57 while PRLR ‐LF expression in the mammary fat pad may respond to changes in body condition/adiposity 137 . These data all lend support to the potential for PRL to act on adipose PRLR to modulate energy homeostasis in a tissue‐specific manner across various physiological states, albeit that there are considerable questions that remain to be answered for the role of PRL in this tissue.…”

“…177 In pigs, we found that PRLR were present in both the epithelial and stromal compartments, similar to the situation in sheep 63,78,179 and rodents 134,177 where the PRLR-LF is the predominant isoform. 78,137 Unfortunately, our understanding of PRLR distribution in the normal human breast remains somewhat limited given that many of the relevant earlier studies were performed using anti-PRLR antibodies that were unsuitable for detecting human PRLR by immunohistochemistry. 6 For example, one paper cited 46 times used B6.2 to localize PRLR in normal breast and tumors.…”