Body distribution of SiO2–Fe3O4core-shell nanoparticles after intravenous injection and intratracheal instillation

Smulders, Stijn; Ketkar-Atre, Ashwini; Luyts, Katrien; Vriens, Hanne; Nobre, Sonia de Sousa; Rivard, Camille; Landuyt, Kirsten Van; Baken, Stijn; Smolders, Erik; Golanski, Luana; Ghosh, Manosij; Vanoirbeek, Jeroen; Himmelreich, Uwe; Hoet, Peter

doi:10.3109/17435390.2015.1100761

Cited by 21 publications

(13 citation statements)

References 33 publications

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“…7 Impressively, NPs accumulated and were retained in the liver for 84 days. 8 Studies have reported that SiNPs exhibit the hepatic toxicity in living organisms. 9,10 Our research has demonstrated that acute exposure to SiNPs can induce liver injury via macrophage infiltration and granuloma formation, 11 whereas repeated exposure to SiNPs led to liver fibrosis in vivo.…”

Section: Introductionmentioning

confidence: 99%

Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro

Duan¹,

Liang²,

Lin³

et al. 2018

IJN

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BackgroundAs a promising nanocarrier in biomedical fields, silica nanoparticles (SiNPs) could transfer from the circulatory system to multiple organs. Among these, blood–liver molecular exchange is a critical factor in biological response to NPs. However, the potential effect of SiNPs on hepatic lipid metabolism is unclear. In this study, we employed three models to attempt discover whether and how SiNPs disturb hepatic lipid metabolism in vivo and in vitro.MethodsFirstly we used ICR mice models to evaulated the effects of SiNPs on the serum and hepatic lipid levels through repeated intravenous administration, meanwhile, the protein expressions of protein markers of lipogenesis (ACC1 and FAS), the key enzyme of fatty acid β-oxidation, CPT1A,and leptin levels in liver were detected by western blot. For verification studies, the model organism zebrafish and cultured hepatic L02 cells were further performed. The TLR5 and adipocytokine-signaling pathway were verified.ResultsInflammatory cell infiltration and mild steatosis induced by SiNPs were observed in the liver. Cholesterol, triglyceride, and low-density lipoprotein cholesterol levels were elevated significantly in both blood serum and liver tissue, whereas the ratio of high-density:low-density lipoprotein cholesterol was markedly decreased. Protein markers of lipogenesis (ACC1 and FAS) were elevated significantly in liver tissue, whereas the key enzyme of fatty acid β-oxidation, CPT1A, was decreased significantly. Interestingly, leptin levels in the SiNP-treated group were also elevated markedly. In addition, SiNPs caused hepatic damage and steatosis in zebrafish and enhanced hyperlipemia in high-cholesterol diet zebrafish. Similarly, SiNPs increased the release of inflammatory cytokines (IL1β, IL6, IL8, and TNFα) and activated the TLR5-signaling pathway in hepatic L02 cells.ConclusionIn summary, our study found that SiNPs triggered hyperlipemia and hepatic steatosis via the TLR5-signaling pathway. This suggests that regulation of TLR5 could be a novel therapeutic target to reduce side effects of NPs in living organisms.

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Section: Introductionmentioning

confidence: 99%

Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro

Duan¹,

Liang²,

Lin³

et al. 2018

IJN

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“…suggesting that the particulate form primarily contributed to the lung absorption of SiO 2 @Fe 3 O 4 NPs. 103 Rapid Detection. According to previous reports, the halflives of nonfunctionalized NMs/NPs in the blood are usually quite short.…”

mentioning

confidence: 99%

Quantification of Nanomaterial/Nanomedicine Trafficking in Vivo

et al. 2017

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Figure 4. Main techniques for labeling NMs/NPs with isotopes and their applications for quantification of NMs/NPs in vivo. (a) Main methods for labeling NMs/NPs with isotopes. Isotopes can be attached to the surface of NMs/NPs through physical interaction such as electrostatic interaction and π−π interaction (adsorption), metal coordination interaction (coordination), chemical reactions (covalent attachment), doping chemistry (doping), or formation of a shell (core−shell structure).

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“…Many studies have investigated the use of Fe 3 O 4 paramagnetic cores (Smulders et al, 2016 ) or gadolinium-based particles (Bianchi et al, 2014 ; Dufort et al, 2015 ) in the diagnosis of lung cancer, which further enables radiosensitizing effects. However, therapeutic systems were also formulated.…”

Section: Surface-engineered Smart Nanocarriers and Targeted Inhalational Lung Cancer Chemotherapymentioning

confidence: 99%

Surface-engineered smart nanocarrier-based inhalation formulations for targeted lung cancer chemotherapy: a review of current practices

Xue

Shou

2021

Drug Delivery

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Lung cancer is the second most common and lethal cancer in the world. Chemotherapy is the preferred treatment modality for lung cancer and prolongs patient survival by effective controlling of tumor growth. However, owing to the nonspecific delivery of anticancer drugs, systemic chemotherapy has limited clinical efficacy and significant systemic adverse effects. Inhalation routes, on the other hand, allow for direct delivery of drugs to the lungs in high local concentrations, enhancing their anti-tumor activity with minimum side effects. Preliminary research studies have shown that inhaled chemotherapy may be tolerated with manageable adverse effects such as bronchospasm and cough. Enhancing the anticancer drugs deposition in tumor cells and limiting their distribution to other healthy cells will therefore increase their clinical efficacy and decrease their local and systemic toxicities. Because of the controlled release and localization of tumors, nanoparticle formulations are a viable option for the delivery of chemotherapeutics to lung cancers via inhalation. The respiratory tract physiology and lung clearance mechanisms are the key barriers to the effective deposition and preservation of inhaled nanoparticle formulations in the lungs. Designing and creating smart nanoformulations to optimize lung deposition, minimize pulmonary clearance, and improve cancerous tissue targeting have been the subject of recent research studies. This review focuses on recent examples of work in this area, along with the opportunities and challenges for the pulmonary delivery of smart nanoformulations to treat lung cancers.

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Body distribution of SiO₂–Fe₃O₄core-shell nanoparticles after intravenous injection and intratracheal instillation

Cited by 21 publications

References 33 publications

Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro

Silica nanoparticles trigger hepatic lipid-metabolism disorder in vivo and in vitro

Quantification of Nanomaterial/Nanomedicine Trafficking in Vivo

Surface-engineered smart nanocarrier-based inhalation formulations for targeted lung cancer chemotherapy: a review of current practices

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