Body Fat and Breast Cancer Risk in Postmenopausal Women: A Longitudinal Study

Rohan, Thomas E.; Heo, Moonseong; Choi, Lydia; Datta, Mridul; Freudenheim, Jo L.; Kamensky, Victor; Ochs‐Balcom, Heather M.; Qi, Lihong; Thomson, Cynthia A.; Vitolins, Mara Z.; Wassertheil‐Smoller, Sylvia; Kabat, Geoffrey C.

doi:10.1155/2013/754815

Cited by 49 publications

(57 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The relation between body fat and BMI has been shown to vary by race/ethnicity (70–72). Nevertheless, an analysis of the Women’s Health Initiative reported similar associations for measurement-based BMI and dual-energy-X-ray-absorptiometry (DXA) based body fat measures (73). We had to rely on waist and hip circumferences measured after diagnosis and had no data available on pre-diagnostic measures.…”

Section: Discussionmentioning

confidence: 97%

Body Size Throughout Adult Life Influences Postmenopausal Breast Cancer Risk among Hispanic Women: The Breast Cancer Health Disparities Study

John

Sangaramoorthy

Hines

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background Few studies have assessed the association of body size with postmenopausal breast cancer (BC) risk in Hispanic women. Findings are inconsistent and appear to contradict those reported for non-Hispanic White (NHW) women. Methods We pooled interview and anthropometric data for 2,023 Hispanic and 2,384 NHW women from two U.S. population-based case-control studies. Using logistic regression analysis, we examined associations of overall and abdominal adiposity with risk of postmenopausal BC defined by estrogen receptor (ER) and progesterone receptor (PR) status. Results Weight gain was associated with increased risk of ER+PR+ BC in Hispanics not currently using menopausal hormone therapy (HT), but only among those with a low young-adult body mass index (BMI). In the subset of Hispanics with data on genetic ancestry, the association with weight gain was limited to women with lower Indigenous American ancestry. Young-adult BMI was inversely associated with both ER+PR+ and ER-PR- BC for both ethnicities combined, with similar, although non-significant, inverse trends in Hispanics and NHWs. Among all Hispanics, regardless of HT use, height was associated with risk of ER-PR-BC and hip circumference with risk of BC overall. Conclusions Body size throughout adult life is associated with BC risk among postmenopausal Hispanic women, as has been reported for NHW women. Associations were specific for BC subtypes defined by hormone receptor status. Impact Avoiding weight gain and maintaining a healthy weight are important strategies to reduce the risk of postmenopausal ER+PR+ BC, the most common BC subtype.

show abstract

Section: Discussionmentioning

confidence: 97%

Body Size Throughout Adult Life Influences Postmenopausal Breast Cancer Risk among Hispanic Women: The Breast Cancer Health Disparities Study

John

Sangaramoorthy

Hines

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…In addition, GPX3 directly targets the ERα gene in white adipose tissue, for which it was proposed as an important mediator of the estrogen effects in association with fat mass (42). Considering the link between visceral fat and breast cancer initiation and progression (43), it is reasonable to observe an overexpression of GPX3 in breast cancer cells. However, more specific studies are required to deeply understand the specific role of GPX3 in breast cancer.…”

Section: Rt-qpcr Evaluations On Human Breast Cancer and Non-cancerousmentioning

confidence: 99%

Comparison of the seleno-transcriptome expression between human non-cancerous mammary epithelial cells and two human breast cancer cell lines

et al. 2017

View full text Add to dashboard Cite

Abstract. Breast cancer is the second most common cause of mortality in women; therefore, the identification of novel putative markers is required to improve its diagnosis and prognosis. Selenium is known to protect mammary epithelial cells from oxidative DNA damage, and to inhibit the initiation phase of carcinogenesis by stimulating DNA repair and apoptosis regulation. Consequently, the present study has focused attention on the selenoprotein family and their involvement in breast cancer. The present study performed a global analysis of the seleno-transcriptome expression in human breast cancer MCF-7 and MDA-MB231 cell lines compared with healthy breast MCF-10A cells using reverse transcription-quantitative polymerase chain reaction. The present data revealed the presence of differently expressed genes in MCF-7 and MDA-MB231 cells compared with MCF-10A cells: Four downregulated [glutathione peroxidase (GPX)1, GPX4, GPX5 and GPX7] and three upregulated (deiodinase iodothyronine, type II, GPX2 and GPX3) genes. Additionally, interactomic investigation were performed by the present study to evaluate the association between the downregulated and upregulated genes, and to identify putative HUB nodes, which represent the centers of association between the genes that are capable of direct control over the gene networks. Network analysis revealed that all differentially regulated genes, with the exception of selenoprotein T, are implicated in the same network that presents three HUB nodes interconnected to the selenoprotein mRNAs, including TP53, estrogen receptor 1 and catenin-β1 (CTNNB1). Overall, these data demonstrated for the first time, a profile of seleno-mRNAs specific for human breast cells, indicating that these genes alter their expression on the basis of the ER-positivity or negativity of breast cancer cells.

show abstract

“…Unlike anthropometric measures, dual‐energy X‐ray absorptiometry (DXA) provides estimates of fat, bone, and bone‐free lean mass comparable to those from more costly methods such as computed tomography and magnetic resonance imaging . Using data from Women's Health Initiative (WHI), we have previously shown that various DXA‐derived measures of body fat were positively associated with risk of postmenopausal breast cancer . More recently, we also demonstrated that among normal BMI postmenopausal women, relatively high whole body fat and trunk fat (measured using DXA) were associated with almost twofold increases in risk of estrogen receptor‐positive (ER+) breast cancer …”

Section: Introductionmentioning

confidence: 99%

The association between DXA‐derived body fat measures and breast cancer risk among postmenopausal women in the Women's Health Initiative

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background Most studies demonstrating an association between excess adiposity and postmenopausal breast cancer have used anthropometric measures, particularly body mass index (BMI). However, more direct body fat measures may more accurately determine the relationship between body fat distribution and breast cancer risk. Methods Cox proportional hazards regression models were created to examine the associations of dual‐energy x‐ray absorptiometry (DXA) body fat measures (at baseline and during follow‐up) with breast cancer risk among 10 931 postmenopausal women from the Women's Health Initiative cohort. A total of 639 incident invasive breast cancer cases (including 484 estrogen receptor positive (ER+) cases) were ascertained after a median follow‐up of 15.0 years. Results Excess whole body fat mass and trunk fat mass were positively associated with risk invasive breast cancer risk. These associations persisted even after additional adjustment for standard anthropometric measures. In time‐dependent analyses, we observed that both whole body fat mass and trunk fat mass, in the highest versus lowest category, were associated with a doubling of risk of invasive breast cancer overall (HR: 2.17; 95% CI: 1.54‐3.05 and 2.20; 1.55‐3.14, respectively) and of ER+ breast cancer (2.05; 1.37‐3.05 and 2.03; 1.34‐3.07, respectively). The remaining DXA measures were also positively associated with breast cancer risk in baseline and time‐dependent analyses. Conclusion These findings suggest that DXA‐derived body fat measures are positively associated with breast cancer risk after adjustment for BMI and other conventional breast cancer risk factors.

show abstract

Body Fat and Breast Cancer Risk in Postmenopausal Women: A Longitudinal Study

Cited by 49 publications

References 49 publications

Body Size Throughout Adult Life Influences Postmenopausal Breast Cancer Risk among Hispanic Women: The Breast Cancer Health Disparities Study

Body Size Throughout Adult Life Influences Postmenopausal Breast Cancer Risk among Hispanic Women: The Breast Cancer Health Disparities Study

Comparison of the seleno-transcriptome expression between human non-cancerous mammary epithelial cells and two human breast cancer cell lines

The association between DXA‐derived body fat measures and breast cancer risk among postmenopausal women in the Women's Health Initiative

Contact Info

Product

Resources

About