Body fat and muscle in relation to heart rate variability in young-to-middle age men: a cross sectional study

Cvijetić, Selma; Macan, Jelena; Boschiero, Dario; Ilich, Jasminka Z.

doi:10.1080/03014460.2023.2180089

Cited by 7 publications

(3 citation statements)

References 55 publications

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“…Thus, CVRR at rest and during deep breathing might offer different efficacies in detecting various autonomic nerve dysfunctions in different diseases or conditions. We found lower BMI and SMI for both male and female inpatients with decreased CVRR at rest and during deep breathing (Table 1 and Table S1), consistent with previous studies showing an association of lower muscle mass with lower HRV in healthy persons 32,33 . In females with decreased CVRR at rest and during deep breathing, the trend toward lower and higher percentages of total body fat mass and skeletal muscle mass, respectively, might indicate a more significant reduction in fat mass than muscle mass.…”

Section: Discussionsupporting

confidence: 90%

Associations of age‐adjusted coefficient of variation of R‐R intervals with autonomic and peripheral nerve function in non‐elderly persons with diabetes

Sugimoto,

Miyaoka,

Sozu

et al. 2023

J of Diabetes Invest

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Aims/IntroductionEarly diagnosis of diabetes‐associated cardiac autonomic neuropathy using the coefficient of variation of R‐R intervals (CVRR) may improve outcomes for individuals with diabetes. The present study examined the associations of decreased CVRR at rest and during deep breathing (DB) with other autonomic nerve function parameters.Materials and MethodsThe electronic records of 141 inpatients with diabetes (22–65 years) admitted to our hospital between March 2015 and March 2019 were analyzed retrospectively. After assessment by exclusion criteria, 51 inpatients were included. All inpatients were assessed for peripheral and autonomic nerve function, clinical characteristics, and physical abilities.ResultsInpatients with decreased CVRR at rest (n = 9 (17.6%)) and during DB (n = 12 (23.5%)) had a longer duration of known diabetes, a higher prevalence of diabetic retinopathy, lower body mass index (BMI), skeletal mass index (SMI), and knee extension strength, and a higher proportion of impaired standing balance. Decreased CVRR at rest was associated with a greater fall in diastolic BP from supine to standing, higher resting HR, longer QTc, longer time of voiding, and sensory symptoms.ConclusionsDecreased CVRR at rest and during deep breathing was associated with lower BMI, SMI, and knee strength and a higher proportion of impaired standing balance among non‐elderly inpatients with diabetes. Decreased CVRR at rest appeared more strongly associated with a greater orthostatic BP decline, higher resting heart rate, longer QTc, lower urinary tract dysfunction, and sensory symptoms than a decreased CVRR during deep breathing.

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Section: Discussionsupporting

confidence: 90%

Associations of age‐adjusted coefficient of variation of R‐R intervals with autonomic and peripheral nerve function in non‐elderly persons with diabetes

Sugimoto,

Miyaoka,

Sozu

et al. 2023

J of Diabetes Invest

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“…It has been observed that lower autonomic modulation in adulthood has been associated with an increased risk of developing cardiovascular diseases. Civejetic et al [ 28 ] observed that CAM was inversely related to adiposity. The underlying mechanism of association between adiposity and CAM can be partially explained by inflammation.…”

Section: Discussionmentioning

confidence: 99%

Association of Sports Practice in Childhood and Adolescence with Cardiac Autonomic Modulation in Adulthood: A Retrospective Epidemiological Study

Christofaro,

Tebar,

Mota

et al. 2024

Sports Med - Open

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Background Practicing sports during childhood and adolescence provides benefits to cardiac autonomic modulation (CAM) at these stages of life. However, it is not known whether these benefits to CAM persist into adulthood. Therefore, the objective of this study was to analyze the association of early sports practice (sports practice in childhood and/or adolescence) with CAM in adult life, regardless of habitual moderate-to-vigorous PA. Methods The sample of the present study consisted of 242 adults (141 women and 101 men; age: 41.99 ± 16.24). The assessment of CAM was performed using heart rate variability indices. Sports practice in childhood and adolescence was assessed using a questionnaire. The intensity of physical activity was assessed using accelerometry. To analyze the association between previous sports practice (childhood and/or adolescence) and CAM, the Generalized Linear Model was adopted, considering CAM indices as continuous variables and early sports practice as a 3-fold factor (no sports practice; sports practice in childhood or adolescence; and sports practice in both childhood and adolescence) adjusted by sex, age, socioeconomic condition, and moderate to vigorous PA. Results Sports practice in childhood was associated with the average standard deviation of all normal RR intervals expressed in milliseconds (SDNN): β = 5.89; 95%CI: 0.25;11.52, and the standard deviation of the long-term intervals between consecutive heartbeats (SD2): β = 7.63; 95%CI:1.04; 14.23 indices. Sports practice in adolescence was associated in adulthood with the SD2 index: β = 7.37; 95%CI: 0.71;14.04. Sports practice in at least one of the periods (childhood or adolescence) was significantly associated with the square root of the mean square of the differences between adjacent normal RR intervals for a period of time expressed in milliseconds (RMSSD) (β = 8.86; 95%CI = 0.71;17.01), and the standard deviation of the instantaneous beat to beat variability (SD1) (β = 6.21; 95%CI = 0.45;11.97). Sports practice at both stages of life was significantly associated with better SDNN (β = 7.70; 95%CI = 1.16;14.23) and SD2 (β = 10.18; 95%CI = 2.51;17.85). Conclusion Early sports practice was associated with better CAM in adulthood, independently of the current physical activity level. Based on these findings, sports practice is encouraged from childhood and adolescence, for benefits to CAM in adult life.

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“…As predefined in ethical guidelines, doctors transmit the information electronically without personal data of the patients to one of us (D.B.). This anonymous submission of data led to several publications using similar techniques [21][22][23][24][25][26]. In the context of new developments, the optical measurement of CBO 2 parameters was added to the armamentarium in this crosssectional study.…”

Section: Discussionmentioning

confidence: 99%

Medically Unexplained Symptoms Are Linked to Chronic Inflammatory Diseases: Is There a Role for Frontal Cerebral Blood Oxygen Content?

Straub,

Boschiero

2024

Neuroimmunomodulation

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Introduction Patients often go to the physician with medically unexplained symptoms (MUS). MUS can be autonomic nervous system-related ‘unspecific’ symptoms, such as palpitations, hearth rhythm alterations, tempera-ture dysregulation (hand, feet), anxiety or MUS can be depressive manifestations, fatigue, somnolence, nausea, hyperalgesia with varying pains and aches, dizziness, etc. Methods In this real-world study, we investigated MUS in a cohort of unselected outpatients from general practi-tioners in Italy. It was our aim to increase the understanding of MUS by using principal component analyses to identify any subcategories of MUS and to check a role of chronic inflammatory diseases. Additionally, we studied cerebral blood oxygen and associations with MUS and chronic inflammatory disease. Results Participants included 1597 subjects (50.6+/-0.4 years, 65%/35% women/men). According to ICD-10 codes, 137 subjects had chronic inflammatory diseases. MUS were checked by a questionnaire with numeric rating scale and cerebral blood flow with optical techniques. The analyses of men and women were strati-fied. Psychological symptom severity was higher in the inflamed compared to the non-inflamed group (fatigue, insomnia in women and men; recent mood changes, daytime sleepiness, anxiety, apathy, cold hands only in women; abnormal appetite and heart rhythm problems only in men). Principal component analysis with MUS provided new subcategories: brain symptoms, gut symptoms and unspecific symp-toms. Brain and gut symptoms were higher in inflamed women and men. Chronic inflammatory diseases and pain were tightly interrelated in men and women (p<0.0001). In women, not in men, average frontal rCBO2 content was higher in inflamed compared to non-inflamed subjects. In men, not in women, individ-uals with pain demonstrated a lower average frontal rCBO2 content compared to pain-free men. MUS did not related to rCBO2 parameters. Conclusion This study shows close relationships between MUS and chronic inflammatory diseases but not between MUS and rCBO2 parameters.

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Body fat and muscle in relation to heart rate variability in young-to-middle age men: a cross sectional study

Cited by 7 publications

References 55 publications

Associations of age‐adjusted coefficient of variation of R‐R intervals with autonomic and peripheral nerve function in non‐elderly persons with diabetes

Associations of age‐adjusted coefficient of variation of R‐R intervals with autonomic and peripheral nerve function in non‐elderly persons with diabetes

Association of Sports Practice in Childhood and Adolescence with Cardiac Autonomic Modulation in Adulthood: A Retrospective Epidemiological Study

Medically Unexplained Symptoms Are Linked to Chronic Inflammatory Diseases: Is There a Role for Frontal Cerebral Blood Oxygen Content?

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