Body fat distributions after postpartum differentiate risk of type 2 diabetes in women with a history of gestational diabetes (Preprint)

Abstract

UNSTRUCTURED We aimed to explore whether the modality of body fat distributions after postpartum is feasible to ascertain T2DM risk in women with a history of GDM. Body fat distributions was determined by Dual–energy X–ray absorptiometry (DXA) in 442 women with the history of GDM from the National Health and Nutrition Examination Survey (NHANES) 2011–2018. The modality of body fat distributions was analyzed using 14 indices provided by DXA. The contribution of body fat distributions to the T2DM risks in women with a history of GDM was evaluated using multivariable logistic regression analysis. We found that T2DM risk was positively associated with the ratio of A to G, VATM, TATM, APFAT, and ANFM, but negatively associated with GYFM and GPFAT in the women with history of GDM. VATM possessed the strongest predictability for T2DM risks among the eight indices (AUC = 0.78). Overall, the modality of body fat distributions in viscera, hips, and thighs after postpartum is capable of ascertaining risk of T2DM in women with a history of GDM. VATM is of the strongest predictability for T2DM risks among the eight indices.