Body Fat Mass and Macronutrient Intake in Relation to Circulating Soluble Leptin Receptor, Free Leptin Index, Adiponectin, and Resistin Concentrations in Healthy Humans

Yannakoulia, Mary; Yiannakouris, Nikos; Blüher, Susann; Matalas, Antonia‐Leda; Klimis‐Zacas, Dorothy; Mantzoros, Christos S.

doi:10.1210/jc.2002-021604

Cited by 386 publications

(325 citation statements)

References 46 publications

Supporting

Mentioning

260

Contrasting

Unclassified

Order By: Relevance

“…Total energy intake and macronutrient composition of the diet were reported to be associated with sOB-R concentrations. 29 On the other hand, the changes of sOB-R and leptin levels were significantly correlated to the changes in weight status and percentage body fat, pointing to a link between fat mass and leptin and sOB-R levels. It has been suggested that the adipose tissue hormone leptin downregulates the secretion of its own binding protein 15,18 based on the findings that (1) leptin administration suppresses sOB-R levels in adults, 8 (2) a downregulation of leptin receptor isoforms by leptin has been demonstrated in vitro, 30,31 and (3) leptin receptor mutations are associated with high sOB-R levels.…”

Section: Discussionmentioning

confidence: 89%

Circulating soluble leptin receptor, leptin, and insulin resistance before and after weight loss in obese children

Reinehr

Kratzsch

Kieß³

et al. 2005

Int J Obes

View full text Add to dashboard Cite

OBJECTIVE:To study the relationships between leptin, soluble leptin receptor (sOB-R), and insulin resistance in obese children before and after weight reduction. METHODS: We determined fasting serum leptin, sOB-R, and insulin resistance index (Homeostasis model assessment (HOMA)) in 36 obese children at baseline and 1 y later and compared them to 72 lean children matched for age, gender, and pubertal stage. The changes of leptin (Dleptin) and sOB-R (DsOB-R) over the 1 y period were correlated to the changes of HOMA (DHOMA), the changes of weight status, and the changes of percentage body fat (D%BF) based on skinfold measurements. Multiple linear regression analyses were conducted for the dependent variables Dleptin and DsOB-R, including DBMI and DHOMA as independent variables adjusted for age, gender, and pubertal stage. Changes of leptin and sOB-R levels were analyzed in 11 obese children after they had lost weight substantially (decrease SDS-BMI40.5) and compared to 11 obese children without substantial weight loss matched for age, gender, and pubertal stage. RESULTS: Obese children showed significantly (Po0.001) higher leptin and lower sOB-R levels. Dleptin correlated significantly to DSDS-BMI (r ¼ 0.28, Po0.05), D%BF (r ¼ 0.44, Po0.05), and DHOMA (r ¼ 0.42, Po0.01), while DsOB-R correlated significantly to DSDS-BMI (r ¼ À0.42, Po0.01) and D%BF (r ¼ À0.47, Po0.01), but not to DHOMA. In contrast to DsOB-R, Dleptin correlated significantly to DHOMA (P ¼ 0.02) in multiple linear regression analysis. Substantial weight loss led to a significant increase in sOB-R (P ¼ 0.02) and to a decrease in HOMA (P ¼ 0.02). In children without substantial weight loss, there were no changes in sOB-R, while HOMA (P ¼ 0.04) and leptin (P ¼ 0.02) increased significantly. CONCLUSIONS: The decrease of sOB-R and the increase of leptin levels in obese children normalized after weight loss. Therefore, these changes are consequences rather than the cause of overweight. In contrast to sOB-R, leptin levels are associated with insulin resistance.

show abstract

Section: Discussionmentioning

confidence: 89%

Circulating soluble leptin receptor, leptin, and insulin resistance before and after weight loss in obese children

Reinehr

Kratzsch

Kieß³

et al. 2005

Int J Obes

View full text Add to dashboard Cite

show abstract

“…The higher serum resistin levels of girls compared to boys are in concordance with most studies in adults. 6,13,16 Besides sexual dimorphism of body fat distribution differences in the sex steroids are discussed to be responsible for the observed differences. 12,15,27,28 However, resistin concentrations have been reported to be independent of menstruation cycle and sex hormones in adult women 7 and resistin levels did not significantly differ between prepubertal and pubertal boys.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 Studies in humans are even more controversial. 4,5 In crosssectional studies in adulthood, serum resistin was reported to be related to fat mass [6][7][8] and to insulin resistance, [9][10][11][12] while other reports reveal no correlations to BMI, percent body fat 11,[13][14][15] or to insulin sensitivity. 13,14,16,17 Longitudinal data are necessary to analyze the relationships between resistin, obesity, and insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

Resistin concentrations before and after weight loss in obese children

et al. 2005

View full text Add to dashboard Cite

Objective: The influences of gender, puberty, and obesity on resistin levels and the longitudinal relationships between insulin resistance, weight loss, and resistin have not yet been studied in childhood. Methods: Age, pubertal stage, gender, weight status (standard deviation score-body mass index (SDS-BMI)), resistin levels, and insulin resistance index calculated by homeostasis model assessment (HOMA) were evaluated in 63 obese children and compared to 36 lean children of same age, gender, and pubertal stage. Furthermore, we analyzed the changes of weight status (SDS-BMI, percentage body fat based on skinfold measurements), waist-to-hip ratio, resistin, and HOMA over a 1-year period in 38 obese children. Results: The resistin levels did not significantly (P ¼ 0.079) differ between obese (median resistin 8.7 ng/ml) and lean children (median resistin 9.7 ng/ml). Resistin concentrations were independent of age and pubertal stage, but girls demonstrated significantly higher resistin levels than boys (P ¼ 0.021). There were no significant correlations between changes of resistin and changes of SDS-BMI (r ¼ 0.14, P ¼ 0.198), changes of percentage body fat (r ¼ À0.01, P ¼ 0.466), changes of waist-to-hip ratio (r ¼ 0.17, P ¼ 0.141), and changes of insulin resistance index (r ¼ 0.01, P ¼ 0.472) over the 1-year period. The weight loss of X0.5 SDS-BMI in 16 children was associated with a significant decrease in HOMA (P ¼ 0.030), while there was no significant change in resistin levels (P ¼ 0.878). Conclusions: Girls demonstrated higher resistin concentrations than boys. Our data do not support a relationship between resistin, insulin resistance index, and weight status in childhood.

show abstract

“…Intraassay CsV was 3.4% and interassay CsV was 6.9%. 18 Retinol binding protein-4 was measured using a RBP-4 (Human) enzyme immunoassay (EIA) kit (Phoenix Pharmaceuticals, Inc., Burlingame, CA, USA). The intra-and interassay CsV were less than 5.0% and less than 14.0%, respectively.…”

Section: Assessmentsmentioning

confidence: 99%

Different actions of losartan and ramipril on adipose tissue activity and vascular remodeling biomarkers in hypertensive patients

et al. 2010

View full text Add to dashboard Cite

We planned a randomized, double blind clinical trial to evaluate whether an antihypertensive intervention at the proximal or distal level of the renin-angiotensin-aldosterone system could have different effects on a broad range of innovative cardiovascular risk biomarkers. A total of 288 hypertensive Caucasian patients (115 men and 113 women), aged X18 years, were enrolled in this study. They were randomized to take losartan 50 mg per day or ramipril 5 mg per day for 1 month and titrated up to 100 mg per day and 10 mg per day for 13 months, respectively. At baseline, 1, 2 and 14 months after therapy initiation, we evaluated the following parameters: body weight, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), M-value, adiponectin (ADN), resistin (r), retinol binding protein-4 (RBP-4), visfatin, vaspin, high-sensitivity C-reactive protein (Hs-CRP), matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). No variation of body weight, BMI, FPG or vaspin was obtained with either treatment. We recorded a similar improvement in SBP, DBP and Hs-CRP with both treatments; however, losartan also increased M-value, ADN and visfatin, whereas ramipril did not. Furthermore, losartan decreased r, RBP-4, MMP-2 and MMP-9, whereas ramipril did not have any effect on these parameters. In conclusion, we observed that short-term treatment with losartan improved several metabolic parameters (M-value, ADN, RBP-4, r and visfatin) and decreased vascular remodeling biomarkers (MMP-2 and MMP-9) in hypertensive subjects, whereas ramipril did not.

show abstract

Body Fat Mass and Macronutrient Intake in Relation to Circulating Soluble Leptin Receptor, Free Leptin Index, Adiponectin, and Resistin Concentrations in Healthy Humans

Cited by 386 publications

References 46 publications

Circulating soluble leptin receptor, leptin, and insulin resistance before and after weight loss in obese children

Circulating soluble leptin receptor, leptin, and insulin resistance before and after weight loss in obese children

Resistin concentrations before and after weight loss in obese children

Different actions of losartan and ramipril on adipose tissue activity and vascular remodeling biomarkers in hypertensive patients

Contact Info

Product

Resources

About