Background In the first part of this study, a variable power-functional creatinine correction (V-PFCRC), normalizing results to 1 g/L creatinine (uCR) was established for total weight spot-urinary arsenic (TWuAs) as an adequate method of urinary dilution. In this second part, the impact of age and sex on TWuAs, V-PFCRC functions, and fluid regulation was investigated in the identical dataset of the first part based on a comprehensive literature review. Methods All samples with age indication, uAsUC <= 500 mcg/L and uCR < 4.5 g/L (n=5585, females n= 2967, males n = 2618) were classified into seven age groups, for which sex-aggregate and disaggregate means (SEs), medians, and ICRs were calculated for uCR and TWuAs in uncorrected (uAsUC), classical CR corrected (CCRC, uAsC), and V-PFCRC (uAsN) results mode. In addition, Pearson correlation analyses were performed for uCR and TWuAs with age. In addition, sex-aggregated - and disaggregated V-PFCRC functions were compared between three numerically similar age groups. Finally, the efficacy of creatinine correction error (CRCE) compensation was assessed by simple power-functional regression analysis (PFRA) in both sexes and seven age bands. Findings The clear male dominance uAsUC (p < 0.001) in aggregate age data and all five adult subgroups separately was found inverted by CCRC (uAsC, p = 0.011) and neutralized by V-PFCRC (uAsN, p = 0.19). Children and adolescents did not exhibit significant sex variations of TWuAs or uCR. A continuous rise of TWuAs with age from adolescence to the beginning of the seventh decade of life was observed in uAsUC, uAsC, and uAsN (0.28 mcg/1g uCR/year). Conversely, TWuAs decreased from childhood to adolescence and in the highest age group. Pearson analysis for all patients between 14 - 72 years and uAsUC < 500 mcg/L revealed significant weak positive correlations (p < 0.001) between TWuAs and age. The log curves between the coefficient a (= uAsN) and exponent b ran higher in younger men and both sexes among seniors, in broad analogy with reportedly higher baseline renal vasopressor activities of Angiotensin II (ATII) and Arginine-Vasopressin (AVP, V1) in these subgroups. The efficacy of V-PFCRC was established based on minimized residual biases of uCR on uAsN in both sexes and all seven age bands (R2 0.0029 - 7.0E-09). Interpretation Sex differences in uAsUC and uAsC are primarily attributable to differentiate urinary dilution and thus are compensated by V-PFCRC. In contrast, age-dependent increases of TWuAs, evident in all results modes, are genuine and should be further accounted for in exposure studies and normal range determinations. While sex and age affect V-PFCRC formulas analog to baseline vasopressor activities of ATII/AVP, they only negligibly affect the correction validity. Adequate perception of power-functional relations between uCR and uAsUC alone, even neglecting these minor sex- and age-specific differences in V-PFCRC correction formulas, results in substantial improvement of dilution adjustment.