Body Height of Children with Bronchial Asthma of Various Severities

Eliseeva, T.I.; Геппе, Н.А.; Tush, E.V.; Khaletskaya, O.V.; Балаболкин, И.И.; Булгакова, В.А.; Kubysheva, Nailya; Ignatov, Stanislav K.

doi:10.1155/2017/8761404

Cited by 6 publications

(7 citation statements)

References 15 publications

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“…Other difficulties are due to age-related and pathophysiological features of the ECM metabolism. It has been demonstrated that the somatic development of the human body and, therefore, the formation of the ECM may depend on the existing chronic pathology [3,18,[26][27][28].…”

Section: Markers Of the State Of The Extracellular Matrixmentioning

confidence: 99%

Extracellular Matrix Markers and Methods for Their Study (Review)

Tush¹,

Eliseeva²,

Khaletskaya³

et al. 2019

Sovrem Tehnol Med

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The extracellular matrix (ECM) is a complex meshwork consisting mainly of proteins and carbohydrates; it is currently viewed as a key factor of tissue organization and homeostasis. In each organ, the composition of ECM is different: it includes a variety of fibrillar components, such as collagens, fibronectin, and elastin, as well as non-fibrillar molecules: proteoglycans, hyaluronan, glycoproteins, and matrix proteins. ECM is an active tissue, where the de novo syntheses of structural components are constantly taking place. In parallel, ECM components undergo degradation catalyzed by a number of enzymes including matrix metalloproteinases. The synthesis and degradation of ECM components are controlled by mediators and cytokines, metabolic, epigenetic, and environmental factors. Currently, a large amount of evidence indicates that modifications (remodeling) of ECM play an important role in the pathogenesis of clinical conditions. This may explain the increasing interest in the markers of ECM remodeling both in health and disease. In recent years, many of the ECM markers were considered targets for diagnosing, predicting, and treating diseases. In this review, we discuss some of the currently known ECM markers and methods used for their determination.

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Section: Markers Of the State Of The Extracellular Matrixmentioning

confidence: 99%

Extracellular Matrix Markers and Methods for Their Study (Review)

Tush¹,

Eliseeva²,

Khaletskaya³

et al. 2019

Sovrem Tehnol Med

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“…In recent years, close attention has been paid to the relationship between the nutritional status of patients and the course of asthma and associated UA diseases. We previously [85][86][87] showed that the severity of asthma is associated with the physical body development and nutritional status of patients. In this regard, it is also of great interest to assess the effect on the ECM of hormones regulating the energy exchange and adipose tissue metabolism.…”

Section: Neurohumoral Regulation Of Metabolism Of the Extracellular Mmentioning

confidence: 99%

Metabolism of the Extracellular Matrix in Bronchial Asthma (Review)

Eliseeva¹,

Tush²,

Krasilnikova³

et al. 2018

Sovrem Tehnol Med

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Bronchial asthma is associated with upper airway (UA) disorders, primarily with allergic rhinitis, which, in turn, occurs in combination with other UA conditions, including hyperplasia of the nasal mucosa. Chronic rhinosinusitis, if confirmed, is a predictor of asthma severity. The pathogenesis of these diseases includes the remodeling (restructuring) of the extracellular matrix and the adjacent UA structures, which is associated with further worsening of the diseases and their resistance to therapy. It is known that remodeling of the lower respiratory tract in bronchial asthma is characterized by epithelial desquamation, hyperplasia of goblet cells, thickening of the basement membrane, fibrosis of the subepithelium, hyperplasia of smooth muscles of the respiratory tract, and increased angiogenesis. At the same time, the UA remodeling in patients with asthma is still poorly understood; the data are still limited and often contradict each other. With isolated allergic rhinitis, the remodeling process is not very much pronounced and is limited, apparently, to a basement membrane thickening. In chronic rhinosinusitis, the UA remodeling manifests by epithelial hyperplasia and an increased sedimentation and degradation of the matrix along with the accumulation of plasma proteins. Despite recent extensive studies, the cellular and molecular mechanisms involved in the respiratory tract remodeling remain largely undetermined, which necessitates further research into these processes. The review addresses several aspects of neuro-humoral control of the extracellular matrix metabolism and the associated remodeling of the upper and lower airway in patients with asthma.

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“…Several studies using hospital- or community-based data have indeed suggested a negative impact of childhood asthma on growth [ 8 – 10 ]. However, other longitudinal studies, including a twin study, found either the null effect of asthma on height [ 11 , 12 ] or a transient effect due to delayed onset of puberty [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

The influence of childhood asthma on adult height: evidence from the UK Biobank

Chen

Yang

Hou

et al. 2022

BMC Med

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Background To elucidate the influence of childhood asthma on adult height after consideration of genetic heterogeneity in height. Methods Based on the UK Biobank, we conducted a matched cohort study, including 13,602 European individuals with asthma diagnosed before 18 years old and 136,008 matched unexposed individuals without such an experience. Ascertainment of asthma was based on self-reported data (97.6%) or clinical diagnosis in healthcare registers (2.4%). We studied three height outcomes, including (1) the attained adult height (in centimeters), (2) the height deviation measured as the difference between a person’s rank of genetically determined height (based on generated polygenetic risk score) and their rank of attained adult height in the study population (deviation in % of height order after standardization), and (3) the presence of height deficit comparing genetically determined and attained height (yes or no). We applied linear mixed-effect models to assess the associations of asthma diagnosed at different ages with attained adult height and height deviation, and conditional logistic regression models to estimate the associations of asthma with the risk of height deficit. Results 40.07% (59,944/149,610) of the study participants were born before 1950, and most of them were men (57.65%). After controlling for multiple covariates, childhood asthma was associated with shorter attained adult height, irrespective of age at asthma diagnosis. However, in the analysis of height deviation (deviation in %), we observed the greatest height deviation among individuals with asthma diagnosed before 4 years of age (− 2.57 [95% CI − 4.14 to − 1.00] and − 2.80 [95% CI − 4.06 to − 1.54] for the age of ≤ 2 and 3–4 years, respectively). The magnitude of height deviation in relation to asthma declined thereafter and became null after age 6. Similarly, there was a statistically significant height deficit in relation to an asthma diagnosis at ages ≤ 2 and 3–4 (odds ratios = 1.21, 95% CI 1.04 to 1.40, and 1.15, 95% CI 1.02 to 1.29) but not thereafter. The result pattern was similar when separately analyzing asthma with or without inhaled glucocorticoid (ICS) use, despite that the estimates were consistently stronger among asthma individuals who used ICS. Conclusions Our results suggest a notable association of childhood asthma, primarily asthma diagnosed at an early age, with adult height, after consideration of genetic heterogeneity in height and use of ICS. This finding highlights the need for surveillance on the growth problems among children with asthma.

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Body Height of Children with Bronchial Asthma of Various Severities

Cited by 6 publications

References 15 publications

Extracellular Matrix Markers and Methods for Their Study (Review)

Extracellular Matrix Markers and Methods for Their Study (Review)

Metabolism of the Extracellular Matrix in Bronchial Asthma (Review)

The influence of childhood asthma on adult height: evidence from the UK Biobank

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