Background: This study aimed to test a conceptual model considering the interrelated role of menorrhagia, body image concern, self-esteem, anxiety and depression, sexual function, on quality of life (QOL) of sterilized women.Methods: The current study was conducted as a retrospective cohort study on 200 sterilized women. Data were collected using a socio-demographic checklist, Short Form Health Survey (SF-12), Pictorial Blood Loss Assessment Chart (PBLAC), Female Sexual Function Index (FSFI), Hospital Anxiety and Depression Scale (HADS), Body Image Concern Inventory (BICI), and Rosenberg Self-Esteem Scale.Results: Results show that anxiety (β =-0.51), sexual function (β =0.15) self-esteem (β =0.15), and body image dissatisfaction (β = -0.10) have a direct effect on women’s QOL. Higher level of anxiety, body dissatisfaction with direct effect can be reduce QOL. Anxiety (β =-0.05), sexual function (β =0.20), and menorrhagia (β =-0.09) with indirect effect impress QOL. Higher level of anxiety with indirect effect thorough self-esteem can worsen QOL (β =-0.05).Conclusion: Regarding the psycho-sexual influence of sterilization on women’s QOL, a comprehensive consultation about the negative consequence of sterilization before TL, and psychotherapeutic and psychosexual help after sterilization should be offered.