Body image perception in acromegaly is not associated with objective acromegalic changes, but depends on depressive symptoms

Dimopoulou, Christina; Leistner, S; Ising, Marcus; Schneider, Harald J.; Schopohl, Jochen; Rutz, Sandra; Kosilek, Robert P; Frohner, Richard; Stalla, G. K.; Sievers, Caroline

doi:10.1530/endoabs.41.ep621

Cited by 2 publications

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“…These differences between symptoms and signs are in accordance with previous studies (12) that demonstrated up to 40% differences at the time of first presentation. Some authors suggest that the perceived body changes in acromegaly are less related to objective findings at the physical exam, but more related to depressive symptoms (27). A recent study of oro-dental state in acromegalic patients also reported a discrepancy between a relatively good objective exam and unsatisfactory self-assessment of oral heath-related QoL (28).…”

Section: Discussionmentioning

confidence: 99%

Clinical features and complications of acromegaly at diagnosis are not all the same: data from two large referral centers

Varlamov

Niculescu

Banskota

et al. 2021

Endocrine Connections

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Purpose: The number of international acromegaly-related registries is increasing; however, heterogeneity of acromegaly symptoms and signs across countries is not well described. We compared clinical disease manifestations at diagnosis between two large University referral centers from two continents. Methods: Retrospective, comparative epidemiological study of acromegaly patients at two centers; 1) C. I. Parhon National Institute of Endocrinology, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania (Parhon), and 2) Pituitary Center, Oregon Health & Science University, Portland, Oregon, United States (OHSU) from approved registries was undertaken. Data were extracted from medical charts and questionnaires. Binary logistic regression analysis was undertaken for the most frequently noted symptoms and clinical signs. Results: Study included 216 patients (87 Parhon, 129 OHSU). Age, sex and median delay in diagnosis were similar between centers. IGF-1 index was higher in patients at Parhon (3.3 vs 2.1, p < 0.001). The top five symptoms at both centers were; enlarged hands/feet, headache, arthralgia, fatigue, and irregular menses in women. A significant difference was noted for multiple signs and symptoms frequency, often >20 percentage points between centers. Center was a predictor of many signs and symptoms, independent of acromegaly biochemical severity or disease duration. Conclusion: We show in the first comparative study that differences in medical practice, documentation, and likely cultural differences can influence patients’ symptom(s) reporting and screening patterns in geographically different populations. Pooling data into large multicenter international registries databases may lead to loss of regional characteristics and thus a mixed overall picture of combined cohorts.

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Section: Discussionmentioning

confidence: 99%

Clinical features and complications of acromegaly at diagnosis are not all the same: data from two large referral centers

Varlamov

Niculescu

Banskota

et al. 2021

Endocrine Connections

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“…Depressive symptoms were associated with the worst body image perception scores; no association was found between body image and cognitive impairment, hormonal excess, or treatment status. 47 Prolactinoma symptoms may trigger various body swings through direct and indirect hormonal changes and lead to edema, pain, and discomfort, which result in diminished quality of life, low self-esteem, and suffering. 27 Illness behavior, according to Mechanic, 48 refers to ''the varying ways individuals respond to bodily indications, how they monitor internal states, define and interpret symptoms, make attributions, take remedial actions and utilize various sources of informal and formal care.''…”

Section: Discussionmentioning

confidence: 99%

Body self-image disturbances in women with prolactinoma

Pereira

Naliato

Moraes³

et al. 2020

Braz. J. Psychiatry

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To evaluate body dissatisfaction and distorted body self-image in women with prolactinoma. Methods: Body dissatisfaction and distorted body self-image were evaluated in 80 women with prolactinoma. All patients were in menacme, 34% had normal body mass index (BMI), and 66% were overweight. Most patients (56.2%) had normal prolactin (PRL) levels and no hyperprolactinemia symptoms (52.5%). The Body Shape Questionnaire (BSQ) was used to assess the patients' dissatisfaction with and concern about their physical form, and the Stunkard Figure Rating Scale (FRS) was used to assess body dissatisfaction and distorted body self-image. The patients were divided according to PRL level (normal vs. elevated) and the presence or absence of prolactinoma symptoms. Results: The normal and elevated PRL groups had similar incidences of body dissatisfaction and distorted body self-image. However, symptomatic patients reported a higher incidence of dissatisfaction than asymptomatic patients. Distorted body self-image was less common among symptomatic patients. Conclusion: Symptomatic patients showed higher body dissatisfaction, but lower body self-image distortion. The presence of symptoms may have been responsible for increased body awareness. The perception of body shape could have triggered feelings of dissatisfaction compared to an ideal lean body. Therefore, a distorted body self-image might not necessarily result in body dissatisfaction in women with prolactinomas.

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Body image perception in acromegaly is not associated with objective acromegalic changes, but depends on depressive symptoms

Cited by 2 publications

References 0 publications

Clinical features and complications of acromegaly at diagnosis are not all the same: data from two large referral centers

Clinical features and complications of acromegaly at diagnosis are not all the same: data from two large referral centers

Body self-image disturbances in women with prolactinoma

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