Body iron, serum ferritin, and nonalcoholic fatty liver disease

Shim, Jae‐Jun

doi:10.3350/kjhep.2012.18.1.105

Cited by 15 publications

(13 citation statements)

References 22 publications

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“…Although a matter of debate, iron overload is increasingly considered to be an integral part of the pathology of nonalcoholic fatty liver disease 54–57. Elevated ferritin levels are associated with the development of metabolic syndrome over 5 years,58 and appear to be a good predictor of vascular damage 59.…”

Section: Mechanisms Of Hepatic Insulin Resistance/steatosismentioning

confidence: 99%

Hepatic function and the cardiometabolic syndrome

Wiernsperger

2013

DMSO

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Despite skeletal muscle being considered by many as the source of insulin resistance, physiology tells us that the liver is a central and cardinal regulator of glucose homeostasis. This is sometimes underestimated because, in contrast with muscle, investigations of liver function are technically very difficult. Nevertheless, recent experimental and clinical research has demonstrated clearly that, due in part to its anatomic position, the liver is exquisitely sensitive to insulin and other hormonal and neural factors, either by direct intrahepatic mechanisms or indirectly by organ cross-talk with muscle or adipose tissue. Because the liver receives absorbed nutrients, these have a direct impact on liver function, whether via a caloric excess or via the nature of food components (eg, fructose, many lipids, and trans fatty acids). An emerging observation with a possibly great future is the increase in intestinal permeability observed as a consequence of high fat intake or bacterial modifications in microbiota, whereby substances normally not crossing the gut gain access to the liver, where inflammation, oxidative stress, and lipid accumulation leads to fatty liver, a situation observed very early in the development of diabetes. The visceral adipose tissue located nearby is another main source of inflammatory substances and oxidative stress, and also acts on hepatocytes and Kupffer cells, resulting in stimulation of macrophages. Liberation of these substances, in particular triglycerides and inflammation factors, into the circulation leads to ectopic fat deposition and vascular damage. Therefore, the liver is directly involved in the development of the prediabetic cardiometabolic syndrome. Treatments are mainly metformin, and possibly statins and vitamin D. A very promising avenue is treatment of the leaky gut, which appears increasingly to be an important causal factor in hepatic insulin resistance and steatosis.

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Section: Mechanisms Of Hepatic Insulin Resistance/steatosismentioning

confidence: 99%

Hepatic function and the cardiometabolic syndrome

Wiernsperger

2013

DMSO

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“…In states of Fe repletion or excess, there is a reduced level of IRP, leading to less TfR production and an increase in ferritin and HAMP synthesis [73].…”

Section: (2)mentioning

confidence: 99%

“…Also, in many advanced cirrhosis cases, TS and serum ferritin were simultaneously elevated, which may indicate Fe overload [13,73,174].…”

Section: Studied Variables Fementioning

confidence: 99%

Study of Serum Copper and Iron in Children with Chronic Liver Diseases

Ibrahim¹

2013

Anat Physiol

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Trace elements have a major role as both oxidants and antioxidants, promoting and protecting from tissue damage respectively. As the liver has a pivotal role in trace elements metabolism and consequenyly their bioavailability, we aimed to measure serum levels of essential trace elements in children with chronic liver diseases (CLDs) regardless the etiology and to study their correlation with liver function tests. Serum zinc (Zn), copper (Cu) and iron (Fe); together with other trace elements parameters; were measured in 50 children with CLDs using spectrophotometry and their levels were compared with those age and sex matched healthy children as controls. Serum Cu, Fe, ferritin and transferrin saturation (TS) were significantly higher in the CLDs group than that in the control group; while serum Zn and total iron binding capacity (TIBC) were significantly lower in the CLDs than that in the control group. Serum Fe, Cu, TS and ferritin were positively correlated with biochemical parameters of liver damage; while serum Zn and TIBC were negatively correlated with biochemical parameters of liver damage. These results encourage inclusion of serum Zn, Cu and Fe as biomarkers for monitoring the severity of liver damage during routine assessment of children with CLDs. We recommended caution to avoid excess Fe and Cu intake in children with CLDs. Moreover, Zn supplementation could be encouraged in children with CLDs regardless its etiology.

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“…Puljiz et al, have also reported a statistically significant correlation between serum ferritin and NAFLD stages [34]. Some studies have shown that concentration of ferritin associated with an increased risk of obesity and diabetes and increased levels of serum ferritin is marker of non-alcoholic fatty liver disease patients [35,36]. In contrast to our results, Angulo et al, have reported that serum ferritin, when controlled for age, obesity, diabetes and the SGOT/SGPT ratio, did not correlate with the severity of NAFLD [37].…”

Section: Discussionmentioning

confidence: 99%

Study of serum ferritin, serum uric acid and plasma malondialdehyde (MDA) levels in non-alcoholic fatty liver disease

Varma¹,

Makwane²,

Kare³

et al. 2016

Int J of Biomed & Adv Res

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Background: Non-alcoholic fatty liver disease (NAFLD) is one of most important cause of fatty liver that may lead to endstage liver disease. Various studies have reported that serum ferritin, serum uric acid and plasma malondialdehyde (MDA) levels are related to the development of NAFLD. Diabetes and obesity are the major risk factors which are associated with NAFLD. The aim of this study was estimation of serum ferritin, serum uric acid and plasma MDA levels in NAFLD patients with diabetes and with obesity. Materials and Methods:In the present study, total (n = 230) subjects were recruited for the study and divided in three groups. Group I; (n = 79) diagnosed cases of non-alcoholic fatty liver disease with diabetes, group II; (n = 71) diagnosed cases of nonalcoholic fatty liver disease with obesity patients and group III included (n = 80) healthy control subjects. Serum ferritin was measured by ELISA method. Estimation of serum uric acid was done by uricase peroxidase colorimetric method. Plasma MDA was estimated by spectrophotometric method. Results: The present study shown that serum ferritin, serum uric acid and plasma MDA levels were significantly increased (p<0.001) in NAFLD with diabetes mellitus patients (333.42±82.93, 14.29±1.87, 7.75±3.35, respectively) as compared with healthy controls (126.30±72.12, 5.19±1.72, 2.79±0.52, respectively), and also significantly increased (p < 0.001) in NAFLD with obesity patients (300.87±85.80, 12.08±2.81, 7.43±3.05, respectively) when they compared with healthy controls (126.30±72.12, 5.19±1.72, 2.79±0.52, respectively). Conclusion: Serum ferritin, serum uric acid and plasma MDA are associated with the increased risk for non-alcoholic fatty liver disease.

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Body iron, serum ferritin, and nonalcoholic fatty liver disease

Cited by 15 publications

References 22 publications

Hepatic function and the cardiometabolic syndrome

Hepatic function and the cardiometabolic syndrome

Study of Serum Copper and Iron in Children with Chronic Liver Diseases

Study of serum ferritin, serum uric acid and plasma malondialdehyde (MDA) levels in non-alcoholic fatty liver disease

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