Body Mass Index and Comorbidities in Adult Severe Asthmatics

Bruno, Andreina; Pace, Elisabetta; Cibella, Fabio; Chanez, Pascal

doi:10.1155/2014/607192

Cited by 31 publications

(42 citation statements)

References 32 publications

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“…The mechanical effect of obesity is of little meaning. Concomitant diseases such as esophageal reflux disease, sleep apnea, and diabetes were more important [7]. The significant increase in the number of exacerbations in this group confirms that obesity exerts a negative influence on the course of asthma.…”

Section: Discussionmentioning

confidence: 57%

“…Obesity mechanically impairs breathing, leading to mild restriction, and moderates the immune system, which results in systemic inflammation [5,6]. In obese people sleep apnea and esophageal reflux are more common [7]. The comparison of two populations of patients suffering from asthma: obese and of normal weight, revealed that in the first group there are more women, the quality of life is lower, asthma exacerbations are more frequent, and the response to inhaled corticosteroids is poorer, which results in a higher demand for corticosteroids [8].…”

Section: Introductionmentioning

confidence: 99%

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The impact of sex and BMI on the clinical course of COPD and bronchial asthma

Wytrychowski¹,

Hans-Wytrychowska²

2016

fmpcr

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Background. Bronchial asthma is a heterogeneous disease, and is one phenotype of asthma with obesity. Chronic obstructive pulmonary disease is the fourth most frequent cause of death in the world. Objectives. The aim of the study was to assess the influence of BMI and sex on the clinical course of uncontrolled asthma and COPD with moderate to severe airflow limitation. Material and methods. The study was performed on 2 groups. Group A: 72 adults suffering from asthma (38 F -females, 34 M -males) with at least 1 exacerbation requiring treatment with systemic corticosteroids in the year before the study. Group B: 79 patients (34 F, 45 M) with COPD Grades 2 and 3 according to GOLD. Data including age, gender, BMI, disease duration, treatment, concomitant diseases, pack-years, and number of exacerbations in the last year were collected. Asthma Control Questionnaire scores in group A and COPD Assessment Test scores in group B were collected. Pulmonary function tests were performed in both groups.Results. There were no differences between females and males in the analyzed variables in both groups. Obese patients (BMI > 30.0 kg/m 2 ) were selected for analysis from group A (18 F, 10 M) and from group B (13 F, 16 M). In group A, the number of exacerbations was significantly lower in males (M 1.3 vs. F 1.9; p = 0.01). In group B the age of obese patients was higher than in patients with BMI ≤ 30.0 (68.3 vs. 62.5; p = 0.002). Conclusion. Poorer control of asthma in obese patients was associated with the female gender. Age is a risk factor for obesity development in patients with COPD.

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Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

The impact of sex and BMI on the clinical course of COPD and bronchial asthma

Wytrychowski¹,

Hans-Wytrychowska²

2016

fmpcr

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“…Overall, the data clearly supports the link between obesity and asthma, and obese and overweight patients have a difficulty in being treated due to reduced efficacy of the treatment(s), and their symptoms are exacerbated by a coexisting obesity 37,38 . Therefore, weight loss in these patients with asthma and obesity may not only lead to the improvements in asthma control, but also improve the response to medications, and overall asthma-related quality of life.…”

Section: Obesity and Asthma Managementmentioning

confidence: 63%

Asthma and Obesity - the Recent Advancements

Bharadwaj

Verma

Deshkar

et al. 2015

MVP Journal of Medical Science

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The incidence of obesity and asthma is increasing globally. Evidence shows that there is a correlation between the two, both epidemiologically and pathophysiologically. The inflammatory link between the two is now being established as obesity is a risk factor for asthma and also plays an important role in its prevention and management. Evidence shows that patients with metabolic disorders such as insulin resistance may be at an increased risk for asthma, however the exact pathophysiology of the same remains unknown. We hereby present an overview of the recent advancement in this field.

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“…The data from a recent study showed that the anthropometric obesity measures correlated with a poor efficacy and poor quality of life and life in obese patients with asthma 34,35 , and increased the risk of hospitalizations 36 . Overall, the data clearly supports the link between obesity and asthma, and obese and overweight patients have a difficulty in being treated due to reduced efficacy of the treatment(s), and their symptoms are exacerbated by a coexisting obesity 37,38 . Therefore, weight loss in these patients with asthma and obesity may not only lead to the improvements in asthma control, but also improve the response to medications, and overall asthma-related quality of life.…”

mentioning

confidence: 63%