Body mass index and ovarian function are associated with endocrine and metabolic abnormalities in women with hyperandrogenic syndrome

Cupisti, S.; Kajaia, N.; Dittrich, Ralf; Duezenli, H; Beckmann, Matthias W.; Mueller, Andreas

doi:10.1530/eje-07-0515

Cited by 80 publications

(68 citation statements)

References 34 publications

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“…In contrast, in two more recent small studies (nZ184 and nZ118 respectively) that analyzed patients with amenorrhea separately from patients with oligomenorrhea, only the former had more pronounced IR than patients with regular menses (12,13). Markers of IR did not differ between patients with oligomenorrhea and patients with regular menses (12,13). We also observed that women with regular menstrual cycles alternating with secondary amenorrhea were more insulin resistant than women with regular menstrual cycles alternating with oligomenorrhea.…”

Section: Tablecontrasting

confidence: 81%

“…However, the latter studies did not differentiate between patients with oligomenorrhea and amenorrhea (10,11). In contrast, in two more recent small studies (nZ184 and nZ118 respectively) that analyzed patients with amenorrhea separately from patients with oligomenorrhea, only the former had more pronounced IR than patients with regular menses (12,13). Markers of IR did not differ between patients with oligomenorrhea and patients with regular menses (12,13).…”

Section: Tablementioning

confidence: 77%

“…Indeed, patients with primary or secondary amenorrhea or oligomenorrhea had more severe hyperandrogenemia than Group D whereas patients with polymenorrhea had a similar degree of hyperandrogenemia with the latter. A previous study reported higher androgen levels in patients with either amenorrhea or oligomenorrhea than in those with normal cycles (13) whereas another did not detect any differences in androgen levels between the three groups, possibly because of limited statistical power (12). Therefore, it appears that the severity of menstrual abnormality also reflects the degree of hyperandrogenemia.…”

Section: Tablementioning

confidence: 86%

“…Therefore, menstrual cycle pattern might serve as a marker of IR in patients with PCOS, as IR can induce oligo-or anovulation and thus menstrual cycle irregularity by exacerbating hyperandrogenemia and by disrupting follicular growth (2). Nevertheless, very few small studies evaluated the association between menstruation abnormalities and the endocrine and metabolic characteristics in PCOS (10,11,12,13).…”

Section: Introductionmentioning

confidence: 99%

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Association between menstrual cycle irregularities and endocrine and metabolic characteristics of the polycystic ovary syndrome

Panidis

Τζιόμαλος

Chatzis

et al. 2013

European Journal of Endocrinology

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Objective: Insulin resistance (IR) is frequent in polycystic ovary syndrome (PCOS) and contributes to the increased risk for type 2 diabetes mellitus and cardiovascular disease of this population. Several markers of IR are used but most are expensive or have limited sensitivity and specificity. Preliminary data suggest that the menstrual cycle pattern correlates with IR in PCOS but existing studies are small. We aimed to assess the relationship between the type of menstrual cycle irregularities and IR in PCOS. Design: Prospective study. Methods: We studied 1285 women with PCOS, divided according to the menstrual cycle pattern. Results: Patients with isolated secondary amenorrhea and those with secondary amenorrhea alternating with regular menstrual cycles were more insulin resistant than patients with regular cycles (Group D). Patients with isolated oligomenorrhea were also more insulin resistant than Group D. However, patients with oligomenorrhea alternating with regular cycles, secondary amenorrhea, or polymenorrhea had comparable levels of markers of IR with Group D. Moreover, patients with oligomenorrhea alternating with regular cycles were less insulin resistant than patients with secondary amenorrhea alternating with regular cycles. Finally, patients with isolated polymenorrhea and those with polymenorrhea alternating with regular cycles had comparable levels of markers of IR with Group D. Conclusions: Amenorrhea is associated with more pronounced IR in PCOS, and oligomenorrhea portends a less excessive risk for IR than amenorrhea whereas polymenorrhea appears to be even more benign metabolically. Therefore, the type of menstrual cycle abnormality appears to represent a useful tool for identifying a more adverse metabolic profile in PCOS.

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Section: Tablecontrasting

confidence: 81%

Section: Tablementioning

confidence: 77%

Section: Tablementioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Association between menstrual cycle irregularities and endocrine and metabolic characteristics of the polycystic ovary syndrome

Panidis

Τζιόμαλος

Chatzis

et al. 2013

European Journal of Endocrinology

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“…All of the assays were carried out in a routine diagnostic endocrine laboratory. TT, DHEAS, SHBG, E, PRL, LH, and FSH were measured with chemiluminescent enzyme immunoassays (Immulite 2000; Siemens Medical Solutions Diagnostics Ltd, Bad Nauheim, Germany), as previously described in detail (25)(26)(27)(28)(29)(30)(31)(32). For the TT-assay, the intraassay coefficients of variation (CV) were 16.3, 11.7, and 10.0% at the levels of 0.93, 2.98, and 5.26 nmol/l.…”

Section: Hormone Measurementsmentioning

confidence: 99%

Effects of transdermal testosterone or oral dydrogesterone on hypoactive sexual desire disorder in transsexual women: results of a pilot study

Kronawitter

Gooren

Zollver³

et al. 2009

European Journal of Endocrinology

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Objective: It has been reported that hypoactive sexual desire disorder (HSDD) affects one-third of transsexual women (defined as postoperative male-to-female transsexuals) receiving estrogen replacement whose bioavailable androgen levels are lower than in ovulating women and comparable with those in surgically postmenopausal women. The aim of this study was to evaluate the efficacy of transdermal testosterone treatment and of oral dydrogesterone in transsexual women with HSDD receiving estrogens. Methods: Seven transsexual women with HSDD were treated with a testosterone patch and nine transsexual women with HSDD were treated with oral dydrogesterone over 24 weeks. The primary end point was the change in the brief profile of female sexual function (B-PFSF) score. Secondary end points were changes in hormonal parameters and side effect assessments. Results: A significant increase in total testosterone and free testosterone levels was observed in the group receiving transdermal testosterone. At 24 weeks, there was a significant improvement in the B-PFSF score showing an improvement in sexual desire among transsexual women treated with the testosterone patch, whereas no change in the B-PFSF score was observed in transsexual women treated with oral dydrogesterone. No side effects were reported. Conclusions: In this pilot study, sexual desire in transsexual women improved significantly after treatment with the testosterone patch, without noticeable side effects.

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Infertility and Subfertility Cofactors in Women with PCOS

Shavit

Tulandi

2017

Infertility in Women With Polycystic Ovary Syndrome

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Body mass index and ovarian function are associated with endocrine and metabolic abnormalities in women with hyperandrogenic syndrome

Abstract: Background: The aim of this study was to evaluate associations of clinical features, such as hirsutism, polycystic ovaries (PCOs), ovulatory dysfunction, and body mass index (BMI) R25 kg/m

Cited by 80 publications

References 34 publications

Association between menstrual cycle irregularities and endocrine and metabolic characteristics of the polycystic ovary syndrome

Association between menstrual cycle irregularities and endocrine and metabolic characteristics of the polycystic ovary syndrome

Effects of transdermal testosterone or oral dydrogesterone on hypoactive sexual desire disorder in transsexual women: results of a pilot study

Infertility and Subfertility Cofactors in Women with PCOS

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